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Commentary: Systems biology and its relevance to alcohol research.

Guo QM, Zakhari S - Alcohol Res Health (2008)

Bottom Line: Systems biology, a new scientific discipline, aims to study the behavior of a biological organization or process in order to understand the function of a dynamic system.This commentary will put into perspective topics discussed in this issue of Alcohol Research & Health, provide insight into why alcohol-induced disorders exemplify the kinds of conditions for which a systems biological approach would be fruitful, and discuss the opportunities and challenges facing alcohol researchers.

View Article: PubMed Central - PubMed

Affiliation: Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland.

ABSTRACT
Systems biology, a new scientific discipline, aims to study the behavior of a biological organization or process in order to understand the function of a dynamic system. This commentary will put into perspective topics discussed in this issue of Alcohol Research & Health, provide insight into why alcohol-induced disorders exemplify the kinds of conditions for which a systems biological approach would be fruitful, and discuss the opportunities and challenges facing alcohol researchers.

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Related in: MedlinePlus

Number of publications with “systems biology” as a key word in the search of the ISI Web of Science. The data plotted are from 2000 to 2006. The Web address for the ISI Web of Science is: http://portal.isiknowledge.com/portal.cgi
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f1-arh-31-1-5: Number of publications with “systems biology” as a key word in the search of the ISI Web of Science. The data plotted are from 2000 to 2006. The Web address for the ISI Web of Science is: http://portal.isiknowledge.com/portal.cgi

Mentions: Until recently, most biologists’ efforts have been devoted to reducing complex biological systems to the properties of individual molecules. However, with the completed sequencing of the genomes of humans, mice, rats, and many other organisms, technological advances in the fields of high-throughput genomics1 and functional genomics2 have generated enormous amounts of information on the properties of genes, RNAs,3 proteins, and metabolic products (i.e., metabolites) in an organism. The billions of data points generated by these high-throughput studies are far beyond the reach of reductionist approaches. High-throughput technologies have offered biologists tremendous opportunities but also have created considerable challenges. How can we take advantage of this wealth of information to understand its biological significance in health and disease? Systems biology is an emerging discipline that deals with, and takes advantage of, these enormous amounts of data. Although scientists and engineers have applied the concept of an integrated systemic approach for years, systems biology has only emerged as a new, distinct discipline to study complex biological systems in the past several years. A database search using the phrase “systems biology” in the ISI Web of Science has found only 3 publications in 2001; in 2006, this number had reached 575 (see figure 1).


Commentary: Systems biology and its relevance to alcohol research.

Guo QM, Zakhari S - Alcohol Res Health (2008)

Number of publications with “systems biology” as a key word in the search of the ISI Web of Science. The data plotted are from 2000 to 2006. The Web address for the ISI Web of Science is: http://portal.isiknowledge.com/portal.cgi
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3860440&req=5

f1-arh-31-1-5: Number of publications with “systems biology” as a key word in the search of the ISI Web of Science. The data plotted are from 2000 to 2006. The Web address for the ISI Web of Science is: http://portal.isiknowledge.com/portal.cgi
Mentions: Until recently, most biologists’ efforts have been devoted to reducing complex biological systems to the properties of individual molecules. However, with the completed sequencing of the genomes of humans, mice, rats, and many other organisms, technological advances in the fields of high-throughput genomics1 and functional genomics2 have generated enormous amounts of information on the properties of genes, RNAs,3 proteins, and metabolic products (i.e., metabolites) in an organism. The billions of data points generated by these high-throughput studies are far beyond the reach of reductionist approaches. High-throughput technologies have offered biologists tremendous opportunities but also have created considerable challenges. How can we take advantage of this wealth of information to understand its biological significance in health and disease? Systems biology is an emerging discipline that deals with, and takes advantage of, these enormous amounts of data. Although scientists and engineers have applied the concept of an integrated systemic approach for years, systems biology has only emerged as a new, distinct discipline to study complex biological systems in the past several years. A database search using the phrase “systems biology” in the ISI Web of Science has found only 3 publications in 2001; in 2006, this number had reached 575 (see figure 1).

Bottom Line: Systems biology, a new scientific discipline, aims to study the behavior of a biological organization or process in order to understand the function of a dynamic system.This commentary will put into perspective topics discussed in this issue of Alcohol Research & Health, provide insight into why alcohol-induced disorders exemplify the kinds of conditions for which a systems biological approach would be fruitful, and discuss the opportunities and challenges facing alcohol researchers.

View Article: PubMed Central - PubMed

Affiliation: Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland.

ABSTRACT
Systems biology, a new scientific discipline, aims to study the behavior of a biological organization or process in order to understand the function of a dynamic system. This commentary will put into perspective topics discussed in this issue of Alcohol Research & Health, provide insight into why alcohol-induced disorders exemplify the kinds of conditions for which a systems biological approach would be fruitful, and discuss the opportunities and challenges facing alcohol researchers.

Show MeSH
Related in: MedlinePlus