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Epigenetic effects of ethanol on the liver and gastrointestinal system.

Shukla SD, Lim RW - Alcohol Res (2013)

Bottom Line: The major pathways affected include DNA methylation, different site-specific modifications in histone proteins, and microRNAs.Ethanol metabolism, cell-signaling cascades, and oxidative stress have been implicated in these responses.Thus, epigenetic effects of ethanol may have a central role in the various pathophysiological responses induced by ethanol in multiple organs and mediated via the liver-GI axis.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Pharmacology & Physiology, School of Medicine, University of Missouri, Columbia, Missouri, USA.

ABSTRACT
The widening web of epigenetic regulatory mechanisms also encompasses ethanol-induced changes in the gastrointestinal (GI)-hepatic system. In the past few years, increasing evidence has firmly established that alcohol modifies several epigenetic parameters in the GI tract and liver. The major pathways affected include DNA methylation, different site-specific modifications in histone proteins, and microRNAs. Ethanol metabolism, cell-signaling cascades, and oxidative stress have been implicated in these responses. Furthermore, ethanol-induced fatty liver (i.e., steatohepatitis) and progression of liver cancer (i.e., hepatic carcinoma) may be consequences of the altered epigenetics. Modification of gene and/or protein expression via epigenetic changes also may contribute to the cross-talk among the GI tract and the liver as well as to systemic changes involving other organs. Thus, epigenetic effects of ethanol may have a central role in the various pathophysiological responses induced by ethanol in multiple organs and mediated via the liver-GI axis.

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Related in: MedlinePlus

Ethanol and its metabolites modify epigenetic pathways in the liver.
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Related In: Results  -  Collection

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f1-arcr-35-1-47: Ethanol and its metabolites modify epigenetic pathways in the liver.

Mentions: The accumulation of all these findings has led to a dramatic shift from a genetic to an epigenetic basis in the conceptual thinking about the causes of disease. This also applies to the causes underlying ethanol-induced conditions, and new developments particularly have highlighted the importance of epigenetic mechanisms in mediating ethanol’s actions in the liver and gastrointestinal (GI) tract (see figure 1). These developments are the focus of this review.


Epigenetic effects of ethanol on the liver and gastrointestinal system.

Shukla SD, Lim RW - Alcohol Res (2013)

Ethanol and its metabolites modify epigenetic pathways in the liver.
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3860425&req=5

f1-arcr-35-1-47: Ethanol and its metabolites modify epigenetic pathways in the liver.
Mentions: The accumulation of all these findings has led to a dramatic shift from a genetic to an epigenetic basis in the conceptual thinking about the causes of disease. This also applies to the causes underlying ethanol-induced conditions, and new developments particularly have highlighted the importance of epigenetic mechanisms in mediating ethanol’s actions in the liver and gastrointestinal (GI) tract (see figure 1). These developments are the focus of this review.

Bottom Line: The major pathways affected include DNA methylation, different site-specific modifications in histone proteins, and microRNAs.Ethanol metabolism, cell-signaling cascades, and oxidative stress have been implicated in these responses.Thus, epigenetic effects of ethanol may have a central role in the various pathophysiological responses induced by ethanol in multiple organs and mediated via the liver-GI axis.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Pharmacology & Physiology, School of Medicine, University of Missouri, Columbia, Missouri, USA.

ABSTRACT
The widening web of epigenetic regulatory mechanisms also encompasses ethanol-induced changes in the gastrointestinal (GI)-hepatic system. In the past few years, increasing evidence has firmly established that alcohol modifies several epigenetic parameters in the GI tract and liver. The major pathways affected include DNA methylation, different site-specific modifications in histone proteins, and microRNAs. Ethanol metabolism, cell-signaling cascades, and oxidative stress have been implicated in these responses. Furthermore, ethanol-induced fatty liver (i.e., steatohepatitis) and progression of liver cancer (i.e., hepatic carcinoma) may be consequences of the altered epigenetics. Modification of gene and/or protein expression via epigenetic changes also may contribute to the cross-talk among the GI tract and the liver as well as to systemic changes involving other organs. Thus, epigenetic effects of ethanol may have a central role in the various pathophysiological responses induced by ethanol in multiple organs and mediated via the liver-GI axis.

Show MeSH
Related in: MedlinePlus