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Genetic and Genomic Web Resources for Research on Alcohol Use and Abuse

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There are two major ways of publishing scientific data and results: (1) the standard peer-reviewed paper, which dates back to volume 1 of the Philosophical Transactions of the Royal Society in 1665; and (2) online distribution of data, resources, and software using the Internet that dates back a mere 21 years to the first Web site at the European Organization for Nuclear Research (CERN) established by Tim Berners-Lee... Think of it as a free suite of genetics and statistics programs that happen to be loaded with genetic and genomic data sets, along with complimentary data on biological responses to alcohol and many other drugs. (For more information, see figure 1A and B) This is another NIAAA-funded project that offers a powerful tool for the integrative analysis of collections of lists of genes and their functional relationships... Like GeneWeaver this is a sophisticated tool for the analysis of sets of genes... It includes species as diverse as yeast, worms, and humans... The site started with a focus on gene expression patterns in the brain of the mouse; however, within the last year, it has expanded rapidly and now also covers gene expression in humans and non-human primates... Scientists interested in brain research should visit this site at least once to see the full power of Web services and Web science—it puts a massive research lab at your fingertips... Because of patient confidentiality it is not possible to directly access key data, as is the case for mouse and rat resources... Still this site provides a comprehensive overview of the data that have been generated and links to virtually all of the associated research papers... Non-human primates have proved to be strikingly faithful models of many aspects of alcoholism in humans, and they provide far better experimental control... This is an international initiative that is making major mutations (knock-outs) in every one of about 19,000 genes in the mammalian (murine) genome... NIAAA contributes to this effort, with a special focus on those genes known to be involved in brain function and suspected to modulate risk of alcoholism... This is a companion to the knockout project (above)... It provides information on how to obtain lines of mice that can be used to turn genes off in specific types of cells at different points in life.

No MeSH data available.


GeneWeaver output graph illustrating this program’s ability to find the connections between six data sets listed to the right in boxes with two interesting candidate genes—GNB5 and GTF2A2 (left side in ovals). These two candidate genes are both located in the region highlighted in the QTL map of Figure 1B.
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f2-arcr-34-3-378: GeneWeaver output graph illustrating this program’s ability to find the connections between six data sets listed to the right in boxes with two interesting candidate genes—GNB5 and GTF2A2 (left side in ovals). These two candidate genes are both located in the region highlighted in the QTL map of Figure 1B.

Mentions: This is another NIAAA-funded project that offers a powerful tool for the integrative analysis of collections of lists of genes and their functional relationships (Baker et al., 2012). This resource-and-analysis tool provides a way of making sense of a large group of related genomic studies. Excellent user interface and tutorials make this a starting point for those with large gene expression data sets. It also is a straightforward of performing analyses of many curated gene sets in the GeneWeaver database (see figure 2).


Genetic and Genomic Web Resources for Research on Alcohol Use and Abuse
GeneWeaver output graph illustrating this program’s ability to find the connections between six data sets listed to the right in boxes with two interesting candidate genes—GNB5 and GTF2A2 (left side in ovals). These two candidate genes are both located in the region highlighted in the QTL map of Figure 1B.
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3860403&req=5

f2-arcr-34-3-378: GeneWeaver output graph illustrating this program’s ability to find the connections between six data sets listed to the right in boxes with two interesting candidate genes—GNB5 and GTF2A2 (left side in ovals). These two candidate genes are both located in the region highlighted in the QTL map of Figure 1B.
Mentions: This is another NIAAA-funded project that offers a powerful tool for the integrative analysis of collections of lists of genes and their functional relationships (Baker et al., 2012). This resource-and-analysis tool provides a way of making sense of a large group of related genomic studies. Excellent user interface and tutorials make this a starting point for those with large gene expression data sets. It also is a straightforward of performing analyses of many curated gene sets in the GeneWeaver database (see figure 2).

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

There are two major ways of publishing scientific data and results: (1) the standard peer-reviewed paper, which dates back to volume 1 of the Philosophical Transactions of the Royal Society in 1665; and (2) online distribution of data, resources, and software using the Internet that dates back a mere 21 years to the first Web site at the European Organization for Nuclear Research (CERN) established by Tim Berners-Lee... Think of it as a free suite of genetics and statistics programs that happen to be loaded with genetic and genomic data sets, along with complimentary data on biological responses to alcohol and many other drugs. (For more information, see figure 1A and B) This is another NIAAA-funded project that offers a powerful tool for the integrative analysis of collections of lists of genes and their functional relationships... Like GeneWeaver this is a sophisticated tool for the analysis of sets of genes... It includes species as diverse as yeast, worms, and humans... The site started with a focus on gene expression patterns in the brain of the mouse; however, within the last year, it has expanded rapidly and now also covers gene expression in humans and non-human primates... Scientists interested in brain research should visit this site at least once to see the full power of Web services and Web science—it puts a massive research lab at your fingertips... Because of patient confidentiality it is not possible to directly access key data, as is the case for mouse and rat resources... Still this site provides a comprehensive overview of the data that have been generated and links to virtually all of the associated research papers... Non-human primates have proved to be strikingly faithful models of many aspects of alcoholism in humans, and they provide far better experimental control... This is an international initiative that is making major mutations (knock-outs) in every one of about 19,000 genes in the mammalian (murine) genome... NIAAA contributes to this effort, with a special focus on those genes known to be involved in brain function and suspected to modulate risk of alcoholism... This is a companion to the knockout project (above)... It provides information on how to obtain lines of mice that can be used to turn genes off in specific types of cells at different points in life.

No MeSH data available.