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Analysis of 30 patients with persistent or recurrent squamous cell carcinoma of the cervix within one year after concurrent chemoradiotherapy.

Liu SP, Yang JX, Cao DY, Shen K - Cancer Biol Med (2013)

Bottom Line: The 2-year survival rate was 21.7%, and the median survival time was 17 months.Patients with persistent or recurrent SCC of the cervix after CCRT exhibited a high rate of distant metastasis with poor prognosis.The pre-therapeutic pelvic or para-aortic lymph node enlargement and SCC-ag >10 ng/mL were identified as the independent risk factors for persistent or recurrent SCC within 1 year after CCRT.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union College, Chinese Academy of Medical Science, Beijing 100730, China.

ABSTRACT

Objective: To investigate the recurrence sites, risk factors, and prognosis of patients with persistent or recurrent squamous cell carcinoma (SCC) of the cervix within one year after undergoing concurrent chemoradiotherapy (CCRT).

Methods: Clinical data of 30 patients with persistent or recurrent SCC of the cervix within one year after CCRT between July 2006 and July 2011 were analyzed retrospectively. These data were compared with those of 35 SCC cases with no signs of recurrence after complete remission. These 35 patients were treated during the same period (between 2006 and 2011) and selected randomly.

Results: Among these 30 patients, 25 exhibited distant metastases of which 14 were observed within 6 months after CCRT. Univariate analysis showed higher incidence of pelvic or para-aortic lymphadenectasis and SCC-ag >10 ng/mL in the group with persistent or recurrent disease before treatment (P<0.01). Multivariate analysis by logistic regression revealed that the pre-therapeutic pelvic or para-aortic lymph node enlargement and SCC-ag >10 ng/mL were the independent risk factors. Palliative chemotherapy was the main treatment option for patients with persistent or recurrent disease. The 2-year survival rate was 21.7%, and the median survival time was 17 months.

Conclusion: Patients with persistent or recurrent SCC of the cervix after CCRT exhibited a high rate of distant metastasis with poor prognosis. The pre-therapeutic pelvic or para-aortic lymph node enlargement and SCC-ag >10 ng/mL were identified as the independent risk factors for persistent or recurrent SCC within 1 year after CCRT.

No MeSH data available.


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Overall survival of patients with persistent or recurrent disease.
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f1: Overall survival of patients with persistent or recurrent disease.

Mentions: In the recurrence group, 4 patients were lost to follow-up. Among the remaining 26 patients, only 1 patient with local recurrence limited to the cervix was completely relieved from the disease after 6 courses of chemotherapy, and showed no signs of recurrence during the 31-month follow-up. Two patients received 12 and 13 interrupted chemotherapy courses, respectively, during which the disease was partially relieved or stabilized, and the follow-up for both patients lasted for 3 years. Meanwhile, 19 patients suffered from disease progression or could not stand the chemotherapy after undergoing an average of 3.3 cycles of chemotherapy, and were thus given symptomatic and supportive treatment. Two patients received symptomatic and supportive treatment after palliative radiotherapy, and 2 patients received simply the symptomatic and supportive treatment due to poor general conditions. The 2-year survival rate of the patients with persistent or recurrent disease was 21.7%, with median survival period of 17 months (Figure 1).


Analysis of 30 patients with persistent or recurrent squamous cell carcinoma of the cervix within one year after concurrent chemoradiotherapy.

Liu SP, Yang JX, Cao DY, Shen K - Cancer Biol Med (2013)

Overall survival of patients with persistent or recurrent disease.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3860346&req=5

f1: Overall survival of patients with persistent or recurrent disease.
Mentions: In the recurrence group, 4 patients were lost to follow-up. Among the remaining 26 patients, only 1 patient with local recurrence limited to the cervix was completely relieved from the disease after 6 courses of chemotherapy, and showed no signs of recurrence during the 31-month follow-up. Two patients received 12 and 13 interrupted chemotherapy courses, respectively, during which the disease was partially relieved or stabilized, and the follow-up for both patients lasted for 3 years. Meanwhile, 19 patients suffered from disease progression or could not stand the chemotherapy after undergoing an average of 3.3 cycles of chemotherapy, and were thus given symptomatic and supportive treatment. Two patients received symptomatic and supportive treatment after palliative radiotherapy, and 2 patients received simply the symptomatic and supportive treatment due to poor general conditions. The 2-year survival rate of the patients with persistent or recurrent disease was 21.7%, with median survival period of 17 months (Figure 1).

Bottom Line: The 2-year survival rate was 21.7%, and the median survival time was 17 months.Patients with persistent or recurrent SCC of the cervix after CCRT exhibited a high rate of distant metastasis with poor prognosis.The pre-therapeutic pelvic or para-aortic lymph node enlargement and SCC-ag >10 ng/mL were identified as the independent risk factors for persistent or recurrent SCC within 1 year after CCRT.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union College, Chinese Academy of Medical Science, Beijing 100730, China.

ABSTRACT

Objective: To investigate the recurrence sites, risk factors, and prognosis of patients with persistent or recurrent squamous cell carcinoma (SCC) of the cervix within one year after undergoing concurrent chemoradiotherapy (CCRT).

Methods: Clinical data of 30 patients with persistent or recurrent SCC of the cervix within one year after CCRT between July 2006 and July 2011 were analyzed retrospectively. These data were compared with those of 35 SCC cases with no signs of recurrence after complete remission. These 35 patients were treated during the same period (between 2006 and 2011) and selected randomly.

Results: Among these 30 patients, 25 exhibited distant metastases of which 14 were observed within 6 months after CCRT. Univariate analysis showed higher incidence of pelvic or para-aortic lymphadenectasis and SCC-ag >10 ng/mL in the group with persistent or recurrent disease before treatment (P<0.01). Multivariate analysis by logistic regression revealed that the pre-therapeutic pelvic or para-aortic lymph node enlargement and SCC-ag >10 ng/mL were the independent risk factors. Palliative chemotherapy was the main treatment option for patients with persistent or recurrent disease. The 2-year survival rate was 21.7%, and the median survival time was 17 months.

Conclusion: Patients with persistent or recurrent SCC of the cervix after CCRT exhibited a high rate of distant metastasis with poor prognosis. The pre-therapeutic pelvic or para-aortic lymph node enlargement and SCC-ag >10 ng/mL were identified as the independent risk factors for persistent or recurrent SCC within 1 year after CCRT.

No MeSH data available.


Related in: MedlinePlus