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Physical exercise habits correlate with gray matter volume of the hippocampus in healthy adult humans.

Killgore WD, Olson EA, Weber M - Sci Rep (2013)

Bottom Line: Physical activity facilitates neurogenesis of dentate cells in the rodent hippocampus, a brain region critical for memory formation and spatial representation.Here, we correlated the number of minutes of self-reported exercise per week with gray matter volume of the hippocampus using voxel-based morphometry (VBM) in 61 healthy adults ranging from 18 to 45 years of age.Findings highlight the relationship between regular physical exercise and brain structure during early to middle adulthood.

View Article: PubMed Central - PubMed

Affiliation: Social, Cognitive and Affective Neuroscience Lab, McLean Hospital, Harvard Medical School.

ABSTRACT
Physical activity facilitates neurogenesis of dentate cells in the rodent hippocampus, a brain region critical for memory formation and spatial representation. Recent findings in humans also suggest that aerobic exercise can lead to increased hippocampal volume and enhanced cognitive functioning in children and elderly adults. However, the association between physical activity and hippocampal volume during the period from early adulthood through middle age has not been effectively explored. Here, we correlated the number of minutes of self-reported exercise per week with gray matter volume of the hippocampus using voxel-based morphometry (VBM) in 61 healthy adults ranging from 18 to 45 years of age. After controlling for age, gender, and total brain volume, total minutes of weekly exercise correlated significantly with volume of the right hippocampus. Findings highlight the relationship between regular physical exercise and brain structure during early to middle adulthood.

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The figure shows the coronal (upper left), sagittal (upper right), and axial (lower left) slices highlighting the location of a cluster of 21 voxels within the right hippocampus (MNI: x = 27, y = −7, z = −21) where the tissue volume showed a significant correlation with the number of Minutes Per Week of exercise, after small volume correction for multiple comparisons (*p < .10, FWE).For visualization purposes, the scatterplot (lower right) shows the significant association between the residualized values for the mean number of minutes of exercise per week and the mean extracted data from the significant cluster in the hippocampus after controlling for age and gender.
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f2: The figure shows the coronal (upper left), sagittal (upper right), and axial (lower left) slices highlighting the location of a cluster of 21 voxels within the right hippocampus (MNI: x = 27, y = −7, z = −21) where the tissue volume showed a significant correlation with the number of Minutes Per Week of exercise, after small volume correction for multiple comparisons (*p < .10, FWE).For visualization purposes, the scatterplot (lower right) shows the significant association between the residualized values for the mean number of minutes of exercise per week and the mean extracted data from the significant cluster in the hippocampus after controlling for age and gender.

Mentions: To further explore the association between exercise variables and hippocampal volume, we conducted a voxel-wise analysis of gray matter volume within two search territories defined by the hippocampal ROIs. These analyses were corrected for multiple comparisons within the volume of the hippocampus. For this analysis, there were no correlated voxels within either the left or right hippocampus for Sessions Per Week or Minutes Per Session. Additionally, no voxels survived correction for multiple comparisons within left hippocampus for the number of exercise Minutes Per Week. There was, however, a cluster of 21 voxels within the right hippocampus (MNI: x = 27, y = −7, z = −21; T57 = 3.38; p = .072, FWE corrected) where the gray matter volume showed a significant correlation with the number of Minutes Per Week of exercise (see Figure 2). There were no voxels within either hippocampus showing a negative correlation between physical exercise and gray matter volume.


Physical exercise habits correlate with gray matter volume of the hippocampus in healthy adult humans.

Killgore WD, Olson EA, Weber M - Sci Rep (2013)

The figure shows the coronal (upper left), sagittal (upper right), and axial (lower left) slices highlighting the location of a cluster of 21 voxels within the right hippocampus (MNI: x = 27, y = −7, z = −21) where the tissue volume showed a significant correlation with the number of Minutes Per Week of exercise, after small volume correction for multiple comparisons (*p < .10, FWE).For visualization purposes, the scatterplot (lower right) shows the significant association between the residualized values for the mean number of minutes of exercise per week and the mean extracted data from the significant cluster in the hippocampus after controlling for age and gender.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3860009&req=5

f2: The figure shows the coronal (upper left), sagittal (upper right), and axial (lower left) slices highlighting the location of a cluster of 21 voxels within the right hippocampus (MNI: x = 27, y = −7, z = −21) where the tissue volume showed a significant correlation with the number of Minutes Per Week of exercise, after small volume correction for multiple comparisons (*p < .10, FWE).For visualization purposes, the scatterplot (lower right) shows the significant association between the residualized values for the mean number of minutes of exercise per week and the mean extracted data from the significant cluster in the hippocampus after controlling for age and gender.
Mentions: To further explore the association between exercise variables and hippocampal volume, we conducted a voxel-wise analysis of gray matter volume within two search territories defined by the hippocampal ROIs. These analyses were corrected for multiple comparisons within the volume of the hippocampus. For this analysis, there were no correlated voxels within either the left or right hippocampus for Sessions Per Week or Minutes Per Session. Additionally, no voxels survived correction for multiple comparisons within left hippocampus for the number of exercise Minutes Per Week. There was, however, a cluster of 21 voxels within the right hippocampus (MNI: x = 27, y = −7, z = −21; T57 = 3.38; p = .072, FWE corrected) where the gray matter volume showed a significant correlation with the number of Minutes Per Week of exercise (see Figure 2). There were no voxels within either hippocampus showing a negative correlation between physical exercise and gray matter volume.

Bottom Line: Physical activity facilitates neurogenesis of dentate cells in the rodent hippocampus, a brain region critical for memory formation and spatial representation.Here, we correlated the number of minutes of self-reported exercise per week with gray matter volume of the hippocampus using voxel-based morphometry (VBM) in 61 healthy adults ranging from 18 to 45 years of age.Findings highlight the relationship between regular physical exercise and brain structure during early to middle adulthood.

View Article: PubMed Central - PubMed

Affiliation: Social, Cognitive and Affective Neuroscience Lab, McLean Hospital, Harvard Medical School.

ABSTRACT
Physical activity facilitates neurogenesis of dentate cells in the rodent hippocampus, a brain region critical for memory formation and spatial representation. Recent findings in humans also suggest that aerobic exercise can lead to increased hippocampal volume and enhanced cognitive functioning in children and elderly adults. However, the association between physical activity and hippocampal volume during the period from early adulthood through middle age has not been effectively explored. Here, we correlated the number of minutes of self-reported exercise per week with gray matter volume of the hippocampus using voxel-based morphometry (VBM) in 61 healthy adults ranging from 18 to 45 years of age. After controlling for age, gender, and total brain volume, total minutes of weekly exercise correlated significantly with volume of the right hippocampus. Findings highlight the relationship between regular physical exercise and brain structure during early to middle adulthood.

Show MeSH