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Physical exercise habits correlate with gray matter volume of the hippocampus in healthy adult humans.

Killgore WD, Olson EA, Weber M - Sci Rep (2013)

Bottom Line: Physical activity facilitates neurogenesis of dentate cells in the rodent hippocampus, a brain region critical for memory formation and spatial representation.Here, we correlated the number of minutes of self-reported exercise per week with gray matter volume of the hippocampus using voxel-based morphometry (VBM) in 61 healthy adults ranging from 18 to 45 years of age.Findings highlight the relationship between regular physical exercise and brain structure during early to middle adulthood.

View Article: PubMed Central - PubMed

Affiliation: Social, Cognitive and Affective Neuroscience Lab, McLean Hospital, Harvard Medical School.

ABSTRACT
Physical activity facilitates neurogenesis of dentate cells in the rodent hippocampus, a brain region critical for memory formation and spatial representation. Recent findings in humans also suggest that aerobic exercise can lead to increased hippocampal volume and enhanced cognitive functioning in children and elderly adults. However, the association between physical activity and hippocampal volume during the period from early adulthood through middle age has not been effectively explored. Here, we correlated the number of minutes of self-reported exercise per week with gray matter volume of the hippocampus using voxel-based morphometry (VBM) in 61 healthy adults ranging from 18 to 45 years of age. After controlling for age, gender, and total brain volume, total minutes of weekly exercise correlated significantly with volume of the right hippocampus. Findings highlight the relationship between regular physical exercise and brain structure during early to middle adulthood.

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Partial correlation plots showing the positive association between the residualized values for the mean number of minutes of exercise per week and the residualized modulated volume data extracted from each hippocampus after controlling for age and gender (*p < .05).
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f1: Partial correlation plots showing the positive association between the residualized values for the mean number of minutes of exercise per week and the residualized modulated volume data extracted from each hippocampus after controlling for age and gender (*p < .05).

Mentions: We correlated the extracted hippocampal volumes with each of the exercise measures, controlling for age and gender. The number of exercise Sessions Per Week was not significantly correlated with either left (partial r = .204, p = .120) or right (partial r = .143, p = .279) hippocampal volume. The number of Minutes Per Session was marginally correlated with the volume of the left (partial r = .245, p = .061) and right (partial r = .254, p = .052) hippocampus, but only at a non-significant trend level. However, when these two variables were combined, there was a significant correlation between the number of Minutes Per Week of exercise and the volume of both left (partial r = .310, p = .017) and right (partial r = .305, p = .019) hippocampus (see Figure 1).


Physical exercise habits correlate with gray matter volume of the hippocampus in healthy adult humans.

Killgore WD, Olson EA, Weber M - Sci Rep (2013)

Partial correlation plots showing the positive association between the residualized values for the mean number of minutes of exercise per week and the residualized modulated volume data extracted from each hippocampus after controlling for age and gender (*p < .05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3860009&req=5

f1: Partial correlation plots showing the positive association between the residualized values for the mean number of minutes of exercise per week and the residualized modulated volume data extracted from each hippocampus after controlling for age and gender (*p < .05).
Mentions: We correlated the extracted hippocampal volumes with each of the exercise measures, controlling for age and gender. The number of exercise Sessions Per Week was not significantly correlated with either left (partial r = .204, p = .120) or right (partial r = .143, p = .279) hippocampal volume. The number of Minutes Per Session was marginally correlated with the volume of the left (partial r = .245, p = .061) and right (partial r = .254, p = .052) hippocampus, but only at a non-significant trend level. However, when these two variables were combined, there was a significant correlation between the number of Minutes Per Week of exercise and the volume of both left (partial r = .310, p = .017) and right (partial r = .305, p = .019) hippocampus (see Figure 1).

Bottom Line: Physical activity facilitates neurogenesis of dentate cells in the rodent hippocampus, a brain region critical for memory formation and spatial representation.Here, we correlated the number of minutes of self-reported exercise per week with gray matter volume of the hippocampus using voxel-based morphometry (VBM) in 61 healthy adults ranging from 18 to 45 years of age.Findings highlight the relationship between regular physical exercise and brain structure during early to middle adulthood.

View Article: PubMed Central - PubMed

Affiliation: Social, Cognitive and Affective Neuroscience Lab, McLean Hospital, Harvard Medical School.

ABSTRACT
Physical activity facilitates neurogenesis of dentate cells in the rodent hippocampus, a brain region critical for memory formation and spatial representation. Recent findings in humans also suggest that aerobic exercise can lead to increased hippocampal volume and enhanced cognitive functioning in children and elderly adults. However, the association between physical activity and hippocampal volume during the period from early adulthood through middle age has not been effectively explored. Here, we correlated the number of minutes of self-reported exercise per week with gray matter volume of the hippocampus using voxel-based morphometry (VBM) in 61 healthy adults ranging from 18 to 45 years of age. After controlling for age, gender, and total brain volume, total minutes of weekly exercise correlated significantly with volume of the right hippocampus. Findings highlight the relationship between regular physical exercise and brain structure during early to middle adulthood.

Show MeSH