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How Much Does AMH Really Vary in Normal Women?

La Marca A, Grisendi V, Griesinger G - Int J Endocrinol (2013)

Bottom Line: It is considered an accurate marker of ovarian reserve, able to reflect the size of the ovarian follicular pool of a woman of reproductive age.In comparison to other hormonal biomarkers such as serum FSH, low intra- and intermenstrual cycle variability have been proposed for AMH.This review summarizes the knowledge regarding within-subject variability, with particular attention on AMH intracycle variability.

View Article: PubMed Central - PubMed

Affiliation: Mother-Infant Department, Institute of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Policlinico di Modena, Largo del Pozzo, 41100 Modena, Italy.

ABSTRACT
Anti-Mullerian Hormone (AMH) is an ovarian hormone expressed in growing follicles that have undergone recruitment from the primordial follicle pool but have not yet been selected for dominance. It is considered an accurate marker of ovarian reserve, able to reflect the size of the ovarian follicular pool of a woman of reproductive age. In comparison to other hormonal biomarkers such as serum FSH, low intra- and intermenstrual cycle variability have been proposed for AMH. This review summarizes the knowledge regarding within-subject variability, with particular attention on AMH intracycle variability. Moreover the impact of ethnicity, body mass index, and smoking behaviour on AMH interindividual variability will be reviewed. Finally changes in AMH serum levels in two conditions of ovarian quiescence, namely contraceptives use and pregnancy, will be discussed. The present review aims at guiding researchers and clinicians in interpreting AMH values and fluctuations in various research and clinical scenarios.

No MeSH data available.


Related in: MedlinePlus

Measurements of AMH versus age in Caucasian (N = 232) and African-American women (N = 200). Total serum concentrations of AMH versus age indicate that AMH decreases with age but is highly variable between women and is more variable among African-American women. The corresponding correlation coefficients (R2) and linear equations are shown. Please note how many African-American women had almost undetectable AMH levels although they were eumenorrhoic (reproduced with permission from Shuh-Huerta et al. [22]).
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fig2: Measurements of AMH versus age in Caucasian (N = 232) and African-American women (N = 200). Total serum concentrations of AMH versus age indicate that AMH decreases with age but is highly variable between women and is more variable among African-American women. The corresponding correlation coefficients (R2) and linear equations are shown. Please note how many African-American women had almost undetectable AMH levels although they were eumenorrhoic (reproduced with permission from Shuh-Huerta et al. [22]).

Mentions: In uni- and multi-variate analyses, black [21, 22] and Hispanic [21] women exhibit serum AMH levels 25% lower than those found in Caucasian women of similar age. Furthermore, an unexpectedly high number of black women has undetectable AMH levels despite relatively young age and regular menstrual cycles, hence indicating a potential discrepancy between actual ovarian reserve and what is indicated by AMH measurement in this population (Figure 2). More research on the underlying biological phenomena and consequences of this finding is clearly urgently needed. However, this finding indicates that care should be taken when using AMH reference values across different ethnicities.


How Much Does AMH Really Vary in Normal Women?

La Marca A, Grisendi V, Griesinger G - Int J Endocrinol (2013)

Measurements of AMH versus age in Caucasian (N = 232) and African-American women (N = 200). Total serum concentrations of AMH versus age indicate that AMH decreases with age but is highly variable between women and is more variable among African-American women. The corresponding correlation coefficients (R2) and linear equations are shown. Please note how many African-American women had almost undetectable AMH levels although they were eumenorrhoic (reproduced with permission from Shuh-Huerta et al. [22]).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3852815&req=5

fig2: Measurements of AMH versus age in Caucasian (N = 232) and African-American women (N = 200). Total serum concentrations of AMH versus age indicate that AMH decreases with age but is highly variable between women and is more variable among African-American women. The corresponding correlation coefficients (R2) and linear equations are shown. Please note how many African-American women had almost undetectable AMH levels although they were eumenorrhoic (reproduced with permission from Shuh-Huerta et al. [22]).
Mentions: In uni- and multi-variate analyses, black [21, 22] and Hispanic [21] women exhibit serum AMH levels 25% lower than those found in Caucasian women of similar age. Furthermore, an unexpectedly high number of black women has undetectable AMH levels despite relatively young age and regular menstrual cycles, hence indicating a potential discrepancy between actual ovarian reserve and what is indicated by AMH measurement in this population (Figure 2). More research on the underlying biological phenomena and consequences of this finding is clearly urgently needed. However, this finding indicates that care should be taken when using AMH reference values across different ethnicities.

Bottom Line: It is considered an accurate marker of ovarian reserve, able to reflect the size of the ovarian follicular pool of a woman of reproductive age.In comparison to other hormonal biomarkers such as serum FSH, low intra- and intermenstrual cycle variability have been proposed for AMH.This review summarizes the knowledge regarding within-subject variability, with particular attention on AMH intracycle variability.

View Article: PubMed Central - PubMed

Affiliation: Mother-Infant Department, Institute of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Policlinico di Modena, Largo del Pozzo, 41100 Modena, Italy.

ABSTRACT
Anti-Mullerian Hormone (AMH) is an ovarian hormone expressed in growing follicles that have undergone recruitment from the primordial follicle pool but have not yet been selected for dominance. It is considered an accurate marker of ovarian reserve, able to reflect the size of the ovarian follicular pool of a woman of reproductive age. In comparison to other hormonal biomarkers such as serum FSH, low intra- and intermenstrual cycle variability have been proposed for AMH. This review summarizes the knowledge regarding within-subject variability, with particular attention on AMH intracycle variability. Moreover the impact of ethnicity, body mass index, and smoking behaviour on AMH interindividual variability will be reviewed. Finally changes in AMH serum levels in two conditions of ovarian quiescence, namely contraceptives use and pregnancy, will be discussed. The present review aims at guiding researchers and clinicians in interpreting AMH values and fluctuations in various research and clinical scenarios.

No MeSH data available.


Related in: MedlinePlus