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The interplay between inflammation, physical activity and metabolic syndrome in a remote male geriatric community in Southern Taiwan: the Tianliao Old People (TOP) study 03.

Chang CL, Lee PT, Chang WT, Chang CS, Chen JH, Tsai LM, Wu CH, Liu PY - Diabetol Metab Syndr (2013)

Bottom Line: We enrolled 309 elderly male residents (mean age: 74.4 ± 6.0 years) in a remote southern Taiwan community.The physical activity was recorded by a standard questionnaire.The non-MetS group had higher amount of median weekly physical activity (183.1 ± 19.0 vs. 173.5 ± 10.6 MET-hr/week, p = 0.029), which was also higher among those with lower hsCRP levels (186.1 ± 14.1 vs. 167.8 ± 38.5 MET-hr/week, p = 0.013).

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Cardiology, Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan. larry@mail.ncku.edu.tw.

ABSTRACT

Background: Both physical activity and inflammation are important in the pathophysiology of metabolic syndrome (MetS). Our study aim is to explore their associations in an elderly male (≥ 65 years old) cohort.

Methods: We enrolled 309 elderly male residents (mean age: 74.4 ± 6.0 years) in a remote southern Taiwan community. The physical activity was recorded by a standard questionnaire. A high-sensitivity C-reactive protein (hsCRP) level > 3.0 mg/L indicated a high inflammatory status.

Results: The total prevalence rate of MetS was 27.8% in this male geriatric cohort. Median hsCRP levels were significantly higher in the MetS group (1.60 ± 0.7 vs. 1.0 ± 0.3 mg/L, p < 0.01), and the risk of elevated hsCRP increased with escalating MetS components (p for trend < 0.001). The non-MetS group had higher amount of median weekly physical activity (183.1 ± 19.0 vs. 173.5 ± 10.6 MET-hr/week, p = 0.029), which was also higher among those with lower hsCRP levels (186.1 ± 14.1 vs. 167.8 ± 38.5 MET-hr/week, p = 0.013). Multivariate analysis showed that higher body mass index (ORs: 1.527, 95% CI: 1.319-1.768, p < 0.01) insulin (OR: 1.128, 95% CI: 1.045-1.218, p < 0.01) and physical activity (ORs: 0.997, 95% IC: 0.994-0.999, p < 0.05) were independent predictors of MetS, but not hsCRP level (p > 0.05).

Conclusions: Reduced physical activity was one major pathophysiological MetS factor in our Asian geriatric participants.

No MeSH data available.


Related in: MedlinePlus

The median of weekly physical activity stratified by the level of each MetS components. HDL-C = high-density lipoprotein, HTN = Hypertension, MetS = metabolic syndrome, TG = triglycerides. **: p < 0.01; *: p < 0.05; NS = not significant. (Blue column: positive for individual risk factor; Red column: negative for individual risk factor).
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Figure 3: The median of weekly physical activity stratified by the level of each MetS components. HDL-C = high-density lipoprotein, HTN = Hypertension, MetS = metabolic syndrome, TG = triglycerides. **: p < 0.01; *: p < 0.05; NS = not significant. (Blue column: positive for individual risk factor; Red column: negative for individual risk factor).

Mentions: Since the physical activity was associated with the prevalence rate of MetS, we also analyzed its association with individual MetS components (Figure 3). We found that either those with lower waist circumference (higher vs. lower: 165.9 ± 24.8 vs. 185.5 ± 17.2 MET-hr/week, p = 0.048) or higher levels of HDL-C (higher vs. lower: 186.1 ± 18.7 vs. 170.6 ± 11.3 MET-hr/week, p = 0.003) had a higher median weekly physical activity. But this phenomenon was not significant regarding hypertension, glucose control or triglyceride level.


The interplay between inflammation, physical activity and metabolic syndrome in a remote male geriatric community in Southern Taiwan: the Tianliao Old People (TOP) study 03.

Chang CL, Lee PT, Chang WT, Chang CS, Chen JH, Tsai LM, Wu CH, Liu PY - Diabetol Metab Syndr (2013)

The median of weekly physical activity stratified by the level of each MetS components. HDL-C = high-density lipoprotein, HTN = Hypertension, MetS = metabolic syndrome, TG = triglycerides. **: p < 0.01; *: p < 0.05; NS = not significant. (Blue column: positive for individual risk factor; Red column: negative for individual risk factor).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3852799&req=5

Figure 3: The median of weekly physical activity stratified by the level of each MetS components. HDL-C = high-density lipoprotein, HTN = Hypertension, MetS = metabolic syndrome, TG = triglycerides. **: p < 0.01; *: p < 0.05; NS = not significant. (Blue column: positive for individual risk factor; Red column: negative for individual risk factor).
Mentions: Since the physical activity was associated with the prevalence rate of MetS, we also analyzed its association with individual MetS components (Figure 3). We found that either those with lower waist circumference (higher vs. lower: 165.9 ± 24.8 vs. 185.5 ± 17.2 MET-hr/week, p = 0.048) or higher levels of HDL-C (higher vs. lower: 186.1 ± 18.7 vs. 170.6 ± 11.3 MET-hr/week, p = 0.003) had a higher median weekly physical activity. But this phenomenon was not significant regarding hypertension, glucose control or triglyceride level.

Bottom Line: We enrolled 309 elderly male residents (mean age: 74.4 ± 6.0 years) in a remote southern Taiwan community.The physical activity was recorded by a standard questionnaire.The non-MetS group had higher amount of median weekly physical activity (183.1 ± 19.0 vs. 173.5 ± 10.6 MET-hr/week, p = 0.029), which was also higher among those with lower hsCRP levels (186.1 ± 14.1 vs. 167.8 ± 38.5 MET-hr/week, p = 0.013).

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Cardiology, Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan. larry@mail.ncku.edu.tw.

ABSTRACT

Background: Both physical activity and inflammation are important in the pathophysiology of metabolic syndrome (MetS). Our study aim is to explore their associations in an elderly male (≥ 65 years old) cohort.

Methods: We enrolled 309 elderly male residents (mean age: 74.4 ± 6.0 years) in a remote southern Taiwan community. The physical activity was recorded by a standard questionnaire. A high-sensitivity C-reactive protein (hsCRP) level > 3.0 mg/L indicated a high inflammatory status.

Results: The total prevalence rate of MetS was 27.8% in this male geriatric cohort. Median hsCRP levels were significantly higher in the MetS group (1.60 ± 0.7 vs. 1.0 ± 0.3 mg/L, p < 0.01), and the risk of elevated hsCRP increased with escalating MetS components (p for trend < 0.001). The non-MetS group had higher amount of median weekly physical activity (183.1 ± 19.0 vs. 173.5 ± 10.6 MET-hr/week, p = 0.029), which was also higher among those with lower hsCRP levels (186.1 ± 14.1 vs. 167.8 ± 38.5 MET-hr/week, p = 0.013). Multivariate analysis showed that higher body mass index (ORs: 1.527, 95% CI: 1.319-1.768, p < 0.01) insulin (OR: 1.128, 95% CI: 1.045-1.218, p < 0.01) and physical activity (ORs: 0.997, 95% IC: 0.994-0.999, p < 0.05) were independent predictors of MetS, but not hsCRP level (p > 0.05).

Conclusions: Reduced physical activity was one major pathophysiological MetS factor in our Asian geriatric participants.

No MeSH data available.


Related in: MedlinePlus