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Family history of hepatocellulcar carcinoma is not associated with its patients' prognosis after hepatectomy.

Huang J, Zhang Y, Chen M, Huang J, Xu L, Chen M - World J Surg Oncol (2013)

Bottom Line: Clinicopathologic characteristics were compared by family history.There were no significant differences between patients with or without family history in basic clinicopathologic characteristics.In either whole group or each stage according to the TNM staging system, first-degree family history was not associated with survival in all patients, hepatitis B virus-positive patients, as well as male patients.

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Affiliation: Department of Hepatobiliary Surgery, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, China. Chminsh@mail.sysu.edu.cn.

ABSTRACT

Background: Family history of liver cancer is a major risk factor for hepatocellular carcinoma (HCC). In this study, we investigated the prognosis of patients with HCC with or without family history.

Methods: Data for 1,313 patients who underwent hepatectomy as initial treatment for HCC between 2000 and 2008 at a tertiary cancer center hospital were retrieved from a prospective database. A positive family history was defined as a self-reported history of HCC in first-degree relatives. Clinicopathologic characteristics were compared by family history. Kaplan-Meier method and Cox proportional hazards regressions were applied for overall survival (OS) and disease-free survival (DFS).

Results: Of 1,313 patients, 169 patients (12.9%) had first-degree relatives with a history of HCC. There were no significant differences between patients with or without family history in basic clinicopathologic characteristics. In either whole group or each stage according to the TNM staging system, first-degree family history was not associated with survival in all patients, hepatitis B virus-positive patients, as well as male patients. Multivariate analysis revealed that first-degree family history was not a prognostic factor, either for OS or DFS.

Conclusion: A first-degree family history of HCC is not associated with its patients' prognosis after hepatectomy.

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Overall (a) and disease-free survival (b) for HBV positive patients with or without family history.
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Figure 2: Overall (a) and disease-free survival (b) for HBV positive patients with or without family history.

Mentions: Since the synergism between HBV and a family history of HCC was noted by several studies, the OS and DFS of HBV positive patients with or without a family history of HCC were compared in Table 3. Similarly, for either OS or DFS, there was no significant difference in all patients nor in subgroups (Table 3, Figure 2).


Family history of hepatocellulcar carcinoma is not associated with its patients' prognosis after hepatectomy.

Huang J, Zhang Y, Chen M, Huang J, Xu L, Chen M - World J Surg Oncol (2013)

Overall (a) and disease-free survival (b) for HBV positive patients with or without family history.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3852743&req=5

Figure 2: Overall (a) and disease-free survival (b) for HBV positive patients with or without family history.
Mentions: Since the synergism between HBV and a family history of HCC was noted by several studies, the OS and DFS of HBV positive patients with or without a family history of HCC were compared in Table 3. Similarly, for either OS or DFS, there was no significant difference in all patients nor in subgroups (Table 3, Figure 2).

Bottom Line: Clinicopathologic characteristics were compared by family history.There were no significant differences between patients with or without family history in basic clinicopathologic characteristics.In either whole group or each stage according to the TNM staging system, first-degree family history was not associated with survival in all patients, hepatitis B virus-positive patients, as well as male patients.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Hepatobiliary Surgery, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, China. Chminsh@mail.sysu.edu.cn.

ABSTRACT

Background: Family history of liver cancer is a major risk factor for hepatocellular carcinoma (HCC). In this study, we investigated the prognosis of patients with HCC with or without family history.

Methods: Data for 1,313 patients who underwent hepatectomy as initial treatment for HCC between 2000 and 2008 at a tertiary cancer center hospital were retrieved from a prospective database. A positive family history was defined as a self-reported history of HCC in first-degree relatives. Clinicopathologic characteristics were compared by family history. Kaplan-Meier method and Cox proportional hazards regressions were applied for overall survival (OS) and disease-free survival (DFS).

Results: Of 1,313 patients, 169 patients (12.9%) had first-degree relatives with a history of HCC. There were no significant differences between patients with or without family history in basic clinicopathologic characteristics. In either whole group or each stage according to the TNM staging system, first-degree family history was not associated with survival in all patients, hepatitis B virus-positive patients, as well as male patients. Multivariate analysis revealed that first-degree family history was not a prognostic factor, either for OS or DFS.

Conclusion: A first-degree family history of HCC is not associated with its patients' prognosis after hepatectomy.

Show MeSH
Related in: MedlinePlus