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Hypocaloric diet supplemented with probiotic cheese improves body mass index and blood pressure indices of obese hypertensive patients--a randomized double-blind placebo-controlled pilot study.

Sharafedtinov KK, Plotnikova OA, Alexeeva RI, Sentsova TB, Songisepp E, Stsepetova J, Smidt I, Mikelsaar M - Nutr J (2013)

Bottom Line: Body mass index (BMI) was significantly reduced (p = 0.031) in the probiotic cheese group versus the control cheese group.Higher values of intestinal lactobacilli after probiotic cheese consumption were associated with higher BMI (r = 0.383, p = 0.0305) and urinary putrescine content (r = 0.475, p = 0.006).In patients simultaneously treated with BP-lowering drugs, similar reductions of BP were observed in both groups.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Microbiology, University of Tartu, Ravila str, 19, Tartu 50411, Estonia. marika.mikelsaar@ut.ee.

ABSTRACT

Background: Gut lactobacilli can affect the metabolic functions of healthy humans. We tested whether a 1500 kcal/d diet supplemented with cheese containing the probiotic Lactobacillus plantarum TENSIA (Deutsche Sammlung für Mikroorganismen, DSM 21380) could reduce some symptoms of metabolic syndrome in Russian adults with obesity and hypertension.

Methods: In this 3-week, randomized, double-blind, placebo-controlled, parallel pilot study, 25 subjects ingested probiotic cheese and 15 ingested control cheese. Fifty grams of each cheese provided 175 kcal of energy. Blood pressure (BP), anthropometric characteristics, markers of liver and kidney function, metabolic indices (plasma glucose, lipids, and cholesterol), and urine polyamines were measured. Counts of fecal lactobacilli and L. plantarum TENSIA were evaluated using molecular methods. The data were analyzed by t-test for independent samples and Spearman's partial correlation analysis.

Results: The probiotic L. plantarum TENSIA was present in variable amounts (529.6 ± 232.5 gene copies) in 16/25 (64%) study subjects. Body mass index (BMI) was significantly reduced (p = 0.031) in the probiotic cheese group versus the control cheese group. The changes in BMI were closely associated with the water content of the body (r = 0.570, p = 0.0007) when adjusted for sex and age. Higher values of intestinal lactobacilli after probiotic cheese consumption were associated with higher BMI (r = 0.383, p = 0.0305) and urinary putrescine content (r = 0.475, p = 0.006). In patients simultaneously treated with BP-lowering drugs, similar reductions of BP were observed in both groups. A positive association was detected between TENSIA colonization and the extent of change of morning diastolic BP (r = 0.617, p = 0.0248) and a trend toward lower values of morning systolic BP (r = -0.527, p = 0.0640) at the end of the study after adjusting for BMI, age, and sex.

Conclusion: In a pilot study of obese hypertensive patients, a hypocaloric diet supplemented with a probiotic cheese helps to reduce BMI and arterial BP values, recognized symptoms of metabolic syndrome.

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Related in: MedlinePlus

Patient dispensation throughout the study and the statistical analysis. Blocked randomization lists were produced by the statistician (MV) and held centrally. All invited hospitalized patients attended the study and gave written informed consent before inclusion.
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Figure 1: Patient dispensation throughout the study and the statistical analysis. Blocked randomization lists were produced by the statistician (MV) and held centrally. All invited hospitalized patients attended the study and gave written informed consent before inclusion.

Mentions: The 40 patients were randomly divided into treatment and control groups according to the mode: 2 patients of treatment group vs.1 patient for control group (Figure 1). The randomized, double-blind, placebo-controlled, parallel-designed, two-armed intervention study was performed and conducted according to the guidelines laid down in the Declaration of Helsinki 1996–2000. The Ethical Committee of the Institute of Nutrition of AMS of Russia approved the study protocol. The trial was completed in accordance with good clinical practice [registered trial ISRCTN76271778]. The demographic, clinical, and medication data of the study and control groups are presented in Table 2.


Hypocaloric diet supplemented with probiotic cheese improves body mass index and blood pressure indices of obese hypertensive patients--a randomized double-blind placebo-controlled pilot study.

Sharafedtinov KK, Plotnikova OA, Alexeeva RI, Sentsova TB, Songisepp E, Stsepetova J, Smidt I, Mikelsaar M - Nutr J (2013)

Patient dispensation throughout the study and the statistical analysis. Blocked randomization lists were produced by the statistician (MV) and held centrally. All invited hospitalized patients attended the study and gave written informed consent before inclusion.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3852723&req=5

Figure 1: Patient dispensation throughout the study and the statistical analysis. Blocked randomization lists were produced by the statistician (MV) and held centrally. All invited hospitalized patients attended the study and gave written informed consent before inclusion.
Mentions: The 40 patients were randomly divided into treatment and control groups according to the mode: 2 patients of treatment group vs.1 patient for control group (Figure 1). The randomized, double-blind, placebo-controlled, parallel-designed, two-armed intervention study was performed and conducted according to the guidelines laid down in the Declaration of Helsinki 1996–2000. The Ethical Committee of the Institute of Nutrition of AMS of Russia approved the study protocol. The trial was completed in accordance with good clinical practice [registered trial ISRCTN76271778]. The demographic, clinical, and medication data of the study and control groups are presented in Table 2.

Bottom Line: Body mass index (BMI) was significantly reduced (p = 0.031) in the probiotic cheese group versus the control cheese group.Higher values of intestinal lactobacilli after probiotic cheese consumption were associated with higher BMI (r = 0.383, p = 0.0305) and urinary putrescine content (r = 0.475, p = 0.006).In patients simultaneously treated with BP-lowering drugs, similar reductions of BP were observed in both groups.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Microbiology, University of Tartu, Ravila str, 19, Tartu 50411, Estonia. marika.mikelsaar@ut.ee.

ABSTRACT

Background: Gut lactobacilli can affect the metabolic functions of healthy humans. We tested whether a 1500 kcal/d diet supplemented with cheese containing the probiotic Lactobacillus plantarum TENSIA (Deutsche Sammlung für Mikroorganismen, DSM 21380) could reduce some symptoms of metabolic syndrome in Russian adults with obesity and hypertension.

Methods: In this 3-week, randomized, double-blind, placebo-controlled, parallel pilot study, 25 subjects ingested probiotic cheese and 15 ingested control cheese. Fifty grams of each cheese provided 175 kcal of energy. Blood pressure (BP), anthropometric characteristics, markers of liver and kidney function, metabolic indices (plasma glucose, lipids, and cholesterol), and urine polyamines were measured. Counts of fecal lactobacilli and L. plantarum TENSIA were evaluated using molecular methods. The data were analyzed by t-test for independent samples and Spearman's partial correlation analysis.

Results: The probiotic L. plantarum TENSIA was present in variable amounts (529.6 ± 232.5 gene copies) in 16/25 (64%) study subjects. Body mass index (BMI) was significantly reduced (p = 0.031) in the probiotic cheese group versus the control cheese group. The changes in BMI were closely associated with the water content of the body (r = 0.570, p = 0.0007) when adjusted for sex and age. Higher values of intestinal lactobacilli after probiotic cheese consumption were associated with higher BMI (r = 0.383, p = 0.0305) and urinary putrescine content (r = 0.475, p = 0.006). In patients simultaneously treated with BP-lowering drugs, similar reductions of BP were observed in both groups. A positive association was detected between TENSIA colonization and the extent of change of morning diastolic BP (r = 0.617, p = 0.0248) and a trend toward lower values of morning systolic BP (r = -0.527, p = 0.0640) at the end of the study after adjusting for BMI, age, and sex.

Conclusion: In a pilot study of obese hypertensive patients, a hypocaloric diet supplemented with a probiotic cheese helps to reduce BMI and arterial BP values, recognized symptoms of metabolic syndrome.

Show MeSH
Related in: MedlinePlus