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Inclusion of CYP3A5 genotyping in a nonparametric population model improves dosing of tacrolimus early after transplantation.

Åsberg A, Midtvedt K, van Guilder M, Størset E, Bremer S, Bergan S, Jelliffe R, Hartmann A, Neely MN - Transpl. Int. (2013)

Bottom Line: The bias and imprecision were 0.35 and 1.38, respectively, in the external data set.Patients with functional CYP3A5 had 26% higher clearance and 37% lower bioavailability.The present models seem applicable for clinical individual dose predictions but need a prospective evaluation.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway; Department of Transplant Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

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Population (left) and individual (right) predicted versus observed plots of the full model without CYP3A5 genotype.
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fig02: Population (left) and individual (right) predicted versus observed plots of the full model without CYP3A5 genotype.

Mentions: The population and individual predicted versus observed plots for the two models are shown in Fig.1 and Fig.2. The full model showed significantly better R2 value (P < 0.00001), but no significant difference in slope (P = 0.46) for the population predictions, and lower bias and imprecision, compared with the reduced model excluding CYP3A5 genotype. The individual predicted versus observed plot was similar for both models, but the bias and imprecision were still lower for the full model.


Inclusion of CYP3A5 genotyping in a nonparametric population model improves dosing of tacrolimus early after transplantation.

Åsberg A, Midtvedt K, van Guilder M, Størset E, Bremer S, Bergan S, Jelliffe R, Hartmann A, Neely MN - Transpl. Int. (2013)

Population (left) and individual (right) predicted versus observed plots of the full model without CYP3A5 genotype.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3852421&req=5

fig02: Population (left) and individual (right) predicted versus observed plots of the full model without CYP3A5 genotype.
Mentions: The population and individual predicted versus observed plots for the two models are shown in Fig.1 and Fig.2. The full model showed significantly better R2 value (P < 0.00001), but no significant difference in slope (P = 0.46) for the population predictions, and lower bias and imprecision, compared with the reduced model excluding CYP3A5 genotype. The individual predicted versus observed plot was similar for both models, but the bias and imprecision were still lower for the full model.

Bottom Line: The bias and imprecision were 0.35 and 1.38, respectively, in the external data set.Patients with functional CYP3A5 had 26% higher clearance and 37% lower bioavailability.The present models seem applicable for clinical individual dose predictions but need a prospective evaluation.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway; Department of Transplant Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

Show MeSH