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A novel approach for quantitative assessment of mucosal damage in inflammatory bowel disease.

Matalka II, Al-Omari FA, Salama RM, Mohtaseb AH - Diagn Pathol (2013)

Bottom Line: One of the main reliable histological features to suggest the diagnosis of inflammatory bowel disease is the presence of significant distortion of the crypt architecture indicating the chronic nature of the disease resulting in mucosal damage.This feature has a considerable intra-observer and inter-observer variability leading to significant subjectivity in colonic biopsy assessment.The developed system proved to be reliable, robust, and minimizes subjectivity and inter- and intra-observer variability.

View Article: PubMed Central - HTML - PubMed

Affiliation: Computer Engineering Department, Hijjawi Faculty for Engineering Technology, Yarmouk University, Irbid 21163, Jordan. fomari@junet.edu.jo.

ABSTRACT

Aims: One of the main reliable histological features to suggest the diagnosis of inflammatory bowel disease is the presence of significant distortion of the crypt architecture indicating the chronic nature of the disease resulting in mucosal damage. This feature has a considerable intra-observer and inter-observer variability leading to significant subjectivity in colonic biopsy assessment. In this paper, we present a novel automated system to assess mucosal damage and architectural distortion in inflammatory bowel disease (IBD).

Methods: The proposed system relies on advanced image understating and processing techniques to segment digitally acquired images of microscopic biopsies, then, to extract key features to quantify the crypts irregularities in shape and distribution. These features were used as inputs to an artificial intelligent classifier that, after a training phase, can carry out the assessment automatically.

Results: The developed system was evaluated using 118 IBD biopsies. 116 out of 118 biopsies were correctly classified as compared to the consensus of three expert pathologists, achieving an overall precision of 98.31%.

Conclusions: An automated intelligent system to quantitatively assess inflammatory bowel disease was developed. The proposed system utilized advanced image understanding techniques together with an intelligent classifier to conduct the assessment. The developed system proved to be reliable, robust, and minimizes subjectivity and inter- and intra-observer variability.

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1797721309305023.

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The 1st to 9th order Fourier Descriptors of four cases graded manually as normal, grade I IBD, grade II, and grade III.
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Figure 7: The 1st to 9th order Fourier Descriptors of four cases graded manually as normal, grade I IBD, grade II, and grade III.

Mentions: For further illustration, four typical cases graded manually as normal, IBD grade I (Mild), grade II (Moderate), and grade III (Severe) were processed according to the proposed methodology. The obtained features are presented in Figures 7, 8 and 9. Figure 7 shows the 1st to 9th order Fourier Descriptors (FDs) of the four cases. Figure 8 shows the average crypts density calculated based on minimal spanning tree (MST). Finally, Figure 9 shows the average distance between muscularis mucosa and the first line of crypts calculated using auto-regression techniques. In this way, all biopsies considered in this study were processed and the database is constructed.


A novel approach for quantitative assessment of mucosal damage in inflammatory bowel disease.

Matalka II, Al-Omari FA, Salama RM, Mohtaseb AH - Diagn Pathol (2013)

The 1st to 9th order Fourier Descriptors of four cases graded manually as normal, grade I IBD, grade II, and grade III.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3852335&req=5

Figure 7: The 1st to 9th order Fourier Descriptors of four cases graded manually as normal, grade I IBD, grade II, and grade III.
Mentions: For further illustration, four typical cases graded manually as normal, IBD grade I (Mild), grade II (Moderate), and grade III (Severe) were processed according to the proposed methodology. The obtained features are presented in Figures 7, 8 and 9. Figure 7 shows the 1st to 9th order Fourier Descriptors (FDs) of the four cases. Figure 8 shows the average crypts density calculated based on minimal spanning tree (MST). Finally, Figure 9 shows the average distance between muscularis mucosa and the first line of crypts calculated using auto-regression techniques. In this way, all biopsies considered in this study were processed and the database is constructed.

Bottom Line: One of the main reliable histological features to suggest the diagnosis of inflammatory bowel disease is the presence of significant distortion of the crypt architecture indicating the chronic nature of the disease resulting in mucosal damage.This feature has a considerable intra-observer and inter-observer variability leading to significant subjectivity in colonic biopsy assessment.The developed system proved to be reliable, robust, and minimizes subjectivity and inter- and intra-observer variability.

View Article: PubMed Central - HTML - PubMed

Affiliation: Computer Engineering Department, Hijjawi Faculty for Engineering Technology, Yarmouk University, Irbid 21163, Jordan. fomari@junet.edu.jo.

ABSTRACT

Aims: One of the main reliable histological features to suggest the diagnosis of inflammatory bowel disease is the presence of significant distortion of the crypt architecture indicating the chronic nature of the disease resulting in mucosal damage. This feature has a considerable intra-observer and inter-observer variability leading to significant subjectivity in colonic biopsy assessment. In this paper, we present a novel automated system to assess mucosal damage and architectural distortion in inflammatory bowel disease (IBD).

Methods: The proposed system relies on advanced image understating and processing techniques to segment digitally acquired images of microscopic biopsies, then, to extract key features to quantify the crypts irregularities in shape and distribution. These features were used as inputs to an artificial intelligent classifier that, after a training phase, can carry out the assessment automatically.

Results: The developed system was evaluated using 118 IBD biopsies. 116 out of 118 biopsies were correctly classified as compared to the consensus of three expert pathologists, achieving an overall precision of 98.31%.

Conclusions: An automated intelligent system to quantitatively assess inflammatory bowel disease was developed. The proposed system utilized advanced image understanding techniques together with an intelligent classifier to conduct the assessment. The developed system proved to be reliable, robust, and minimizes subjectivity and inter- and intra-observer variability.

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1797721309305023.

Show MeSH
Related in: MedlinePlus