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The Sinus That Breeds Fungus: Subcutaneous Zygomycosis Caused by Basidiobolus ranarum at the Injection Site.

Jayanth ST, Gaikwad P, Promila M, Muthusami JC - Case Rep Infect Dis (2013)

Bottom Line: Subcutaneous zygomycosis is caused by Basidiobolus ranarum which is endemic in India.She underwent an excision of the sinus tract, the culture of which yielded B. ranarum.The wound improved with oral potassium iodide.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Christian Medical College, Vellore, India.

ABSTRACT
Subcutaneous zygomycosis is caused by Basidiobolus ranarum which is endemic in India. We report a case of a housewife who presented with a persistent discharging sinus from the right gluteal region subsequent to an intramuscular injection which was refractory to empirical antituberculous therapy. She underwent an excision of the sinus tract, the culture of which yielded B. ranarum. The wound improved with oral potassium iodide.

No MeSH data available.


Related in: MedlinePlus

Completely healed wound at one-year follow-up.
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fig2: Completely healed wound at one-year follow-up.

Mentions: A provisional diagnosis of a soft tissue infection due to atypical mycobacteria was made. The sinus tract was excised and a portion of the specimen was sent for histopathological as well as mycological examinations. Haematoxylin and eosin stained sections revealed inflammatory granulation tissue and foreign body granulomas with necrosis in the sinus tract. Two days postoperatively a blackish discoloration of the edge of the surgical wound was noted and was debrided. A calcofluor white preparation of the debrided tissue revealed broad, irregular, and aseptate hyphae. Culture on Sabouraud's dextrose agar showed a creamy white, waxy, and glabrous colony with many radial folds. On performing lactophenol cotton blue wet mount of the fungus, aseptate hyphae, and numerous globose, smooth walled zygospores with characteristic conjugation beaks were observed (Figure 1). The fungus was identified as Basidiobolus ranarum. There was an excellent response to oral potassium iodide in our patient with complete resolution in six months (Figure 2).


The Sinus That Breeds Fungus: Subcutaneous Zygomycosis Caused by Basidiobolus ranarum at the Injection Site.

Jayanth ST, Gaikwad P, Promila M, Muthusami JC - Case Rep Infect Dis (2013)

Completely healed wound at one-year follow-up.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3852275&req=5

fig2: Completely healed wound at one-year follow-up.
Mentions: A provisional diagnosis of a soft tissue infection due to atypical mycobacteria was made. The sinus tract was excised and a portion of the specimen was sent for histopathological as well as mycological examinations. Haematoxylin and eosin stained sections revealed inflammatory granulation tissue and foreign body granulomas with necrosis in the sinus tract. Two days postoperatively a blackish discoloration of the edge of the surgical wound was noted and was debrided. A calcofluor white preparation of the debrided tissue revealed broad, irregular, and aseptate hyphae. Culture on Sabouraud's dextrose agar showed a creamy white, waxy, and glabrous colony with many radial folds. On performing lactophenol cotton blue wet mount of the fungus, aseptate hyphae, and numerous globose, smooth walled zygospores with characteristic conjugation beaks were observed (Figure 1). The fungus was identified as Basidiobolus ranarum. There was an excellent response to oral potassium iodide in our patient with complete resolution in six months (Figure 2).

Bottom Line: Subcutaneous zygomycosis is caused by Basidiobolus ranarum which is endemic in India.She underwent an excision of the sinus tract, the culture of which yielded B. ranarum.The wound improved with oral potassium iodide.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Christian Medical College, Vellore, India.

ABSTRACT
Subcutaneous zygomycosis is caused by Basidiobolus ranarum which is endemic in India. We report a case of a housewife who presented with a persistent discharging sinus from the right gluteal region subsequent to an intramuscular injection which was refractory to empirical antituberculous therapy. She underwent an excision of the sinus tract, the culture of which yielded B. ranarum. The wound improved with oral potassium iodide.

No MeSH data available.


Related in: MedlinePlus