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Enamel matrix derivative for replanted teeth in animal models: a systematic review and meta-analysis.

Kim SG, Ryu SI - Restor Dent Endod (2013)

Bottom Line: To investigate the effect of enamel matrix derivative (EMD) on periodontal healing of replanted teeth in animal models.The pooled estimates showed a significantly higher normal healing and surface resorption and significantly less inflammatory and replacement resorption in EMD-treated groups compared with non-EMD-treated groups.However, no definite conclusion could be drawn with regard to the effect of EMD on periodontal healing and root resorption when no periodontal ligaments exist.

View Article: PubMed Central - PubMed

Affiliation: Division of Endodontics, College of Dental Medicine, Columbia University, New York, USA.

ABSTRACT

Objectives: To investigate the effect of enamel matrix derivative (EMD) on periodontal healing of replanted teeth in animal models.

Materials and methods: The authors searched MEDLINE, PubMed, EMBASE, Cochrane Library, Web of Knowledge and Scopus for articles published up to Oct 2012. Animal studies in which EMD was applied in transplanted or replanted teeth with adequate controls and histological data were considered. Normal periodontal healing or root resorption determined by histology after EMD was applied in replanted teeth with adequate controls was used as outcome measures. The following search strategy was used: ('Emdogain' OR 'enamel matrix proteins' OR 'enamel matrix derivative') AND ('avulsion' OR 'transplantion' OR 'autotransplantation' OR 'replantation').

Results: Six animal studies were included in the final review. There was great heterogeneity in study design among included studies. Two studies with similar study designs were identified and analyzed by a meta-analysis. The pooled estimates showed a significantly higher normal healing and surface resorption and significantly less inflammatory and replacement resorption in EMD-treated groups compared with non-EMD-treated groups.

Conclusions: With the limitations of this systematic review, the use of EMD led to greater normal periodontal healing and surface root resorption and less inflammatory and replacement root resorption in the presence of periodontal ligaments. However, no definite conclusion could be drawn with regard to the effect of EMD on periodontal healing and root resorption when no periodontal ligaments exist.

No MeSH data available.


Related in: MedlinePlus

Effect of EMD on surface resorption in the presence of PDL. EMD, enamel matrix derivative; PDL, periodontal ligament; Std diff, standardized difference; CI, confidence interval.
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Figure 3: Effect of EMD on surface resorption in the presence of PDL. EMD, enamel matrix derivative; PDL, periodontal ligament; Std diff, standardized difference; CI, confidence interval.

Mentions: Surface resorption. The pooled estimates showed a significantly higher surface resorption in EMD-treated groups compared with non-EMD-treated groups (Z = 5.438, p < 0.001) (Figure 3). The heterogeneity among studies existed (Q = 10.123, df(Q) = 1, p = 0.001, I2 = 90.122).


Enamel matrix derivative for replanted teeth in animal models: a systematic review and meta-analysis.

Kim SG, Ryu SI - Restor Dent Endod (2013)

Effect of EMD on surface resorption in the presence of PDL. EMD, enamel matrix derivative; PDL, periodontal ligament; Std diff, standardized difference; CI, confidence interval.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3843029&req=5

Figure 3: Effect of EMD on surface resorption in the presence of PDL. EMD, enamel matrix derivative; PDL, periodontal ligament; Std diff, standardized difference; CI, confidence interval.
Mentions: Surface resorption. The pooled estimates showed a significantly higher surface resorption in EMD-treated groups compared with non-EMD-treated groups (Z = 5.438, p < 0.001) (Figure 3). The heterogeneity among studies existed (Q = 10.123, df(Q) = 1, p = 0.001, I2 = 90.122).

Bottom Line: To investigate the effect of enamel matrix derivative (EMD) on periodontal healing of replanted teeth in animal models.The pooled estimates showed a significantly higher normal healing and surface resorption and significantly less inflammatory and replacement resorption in EMD-treated groups compared with non-EMD-treated groups.However, no definite conclusion could be drawn with regard to the effect of EMD on periodontal healing and root resorption when no periodontal ligaments exist.

View Article: PubMed Central - PubMed

Affiliation: Division of Endodontics, College of Dental Medicine, Columbia University, New York, USA.

ABSTRACT

Objectives: To investigate the effect of enamel matrix derivative (EMD) on periodontal healing of replanted teeth in animal models.

Materials and methods: The authors searched MEDLINE, PubMed, EMBASE, Cochrane Library, Web of Knowledge and Scopus for articles published up to Oct 2012. Animal studies in which EMD was applied in transplanted or replanted teeth with adequate controls and histological data were considered. Normal periodontal healing or root resorption determined by histology after EMD was applied in replanted teeth with adequate controls was used as outcome measures. The following search strategy was used: ('Emdogain' OR 'enamel matrix proteins' OR 'enamel matrix derivative') AND ('avulsion' OR 'transplantion' OR 'autotransplantation' OR 'replantation').

Results: Six animal studies were included in the final review. There was great heterogeneity in study design among included studies. Two studies with similar study designs were identified and analyzed by a meta-analysis. The pooled estimates showed a significantly higher normal healing and surface resorption and significantly less inflammatory and replacement resorption in EMD-treated groups compared with non-EMD-treated groups.

Conclusions: With the limitations of this systematic review, the use of EMD led to greater normal periodontal healing and surface root resorption and less inflammatory and replacement root resorption in the presence of periodontal ligaments. However, no definite conclusion could be drawn with regard to the effect of EMD on periodontal healing and root resorption when no periodontal ligaments exist.

No MeSH data available.


Related in: MedlinePlus