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Disruption of orbitofronto-striatal functional connectivity underlies maladaptive persistent behaviors in alcohol-dependent patients.

Lee S, Lee E, Ku J, Yoon KJ, Namkoong K, Jung YC - Psychiatry Investig (2013)

Bottom Line: In contrast, alcohol dependent patients persisted to the first established behavioral strategy.The mOFC-dorsal striatum functional connectivity was impaired in the alcohol-dependent patients, but increased in correlation with the duration of abstinence.Our findings support that the disruption of the mOFC-striatal circuitry contribute to the maldaptive persistent behaviors in alcohol dependent patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

ABSTRACT

Objective: Alcohol dependence is characterized by persistent alcohol-seeking despite negative consequences. Previous studies suggest that maladaptive persistent behaviors reflect alcohol-induced brain changes that cause alterations in the cortico-striatal-limbic circuit.

Methods: Twenty one alcohol dependent patients and 24 age-matched healthy controls performed a decision-making task during functional MRI. We defined the medial orbitofrontal cortex (mOFC) as a region-of-interest and performed seed-based functional connectivity analysis.

Results: Healthy controls were more flexible in adapting an alternative behavioral strategy, which correlated with stronger mOFC-dorsal striatum functional connectivity. In contrast, alcohol dependent patients persisted to the first established behavioral strategy. The mOFC-dorsal striatum functional connectivity was impaired in the alcohol-dependent patients, but increased in correlation with the duration of abstinence.

Conclusion: Our findings support that the disruption of the mOFC-striatal circuitry contribute to the maldaptive persistent behaviors in alcohol dependent patients.

No MeSH data available.


Related in: MedlinePlus

A: Design of Odd-Even-Pass task. The visual stimuli were presented for 2500 ms and then the screen asked to choose between odd, even or pass within 1500 ms. Each response was immediately followed by a feedback and inter-stimulus interval was jittered from 1000 ms to 6000 ms. B and C: Behavioral performance. Pass responses (B); Reaction time (C).
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Figure 1: A: Design of Odd-Even-Pass task. The visual stimuli were presented for 2500 ms and then the screen asked to choose between odd, even or pass within 1500 ms. Each response was immediately followed by a feedback and inter-stimulus interval was jittered from 1000 ms to 6000 ms. B and C: Behavioral performance. Pass responses (B); Reaction time (C).

Mentions: Figures of coins were used as visual stimuli, which were presented through nonmagnetic goggles. The visual stimulus was presented for 2000 ms (evaluate phase) and then the participants were asked to guess whether the total number of coins was 'odd' or 'even' within 1500 ms (response phase) (Figure 1A). In addition to 'odd' and 'even', the participants were instructed that they could select a third option 'pass' in order to move on to the next trial without any gain or loss. Each response was immediately followed by a feedback (i.e., gain or loss one point).


Disruption of orbitofronto-striatal functional connectivity underlies maladaptive persistent behaviors in alcohol-dependent patients.

Lee S, Lee E, Ku J, Yoon KJ, Namkoong K, Jung YC - Psychiatry Investig (2013)

A: Design of Odd-Even-Pass task. The visual stimuli were presented for 2500 ms and then the screen asked to choose between odd, even or pass within 1500 ms. Each response was immediately followed by a feedback and inter-stimulus interval was jittered from 1000 ms to 6000 ms. B and C: Behavioral performance. Pass responses (B); Reaction time (C).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3843019&req=5

Figure 1: A: Design of Odd-Even-Pass task. The visual stimuli were presented for 2500 ms and then the screen asked to choose between odd, even or pass within 1500 ms. Each response was immediately followed by a feedback and inter-stimulus interval was jittered from 1000 ms to 6000 ms. B and C: Behavioral performance. Pass responses (B); Reaction time (C).
Mentions: Figures of coins were used as visual stimuli, which were presented through nonmagnetic goggles. The visual stimulus was presented for 2000 ms (evaluate phase) and then the participants were asked to guess whether the total number of coins was 'odd' or 'even' within 1500 ms (response phase) (Figure 1A). In addition to 'odd' and 'even', the participants were instructed that they could select a third option 'pass' in order to move on to the next trial without any gain or loss. Each response was immediately followed by a feedback (i.e., gain or loss one point).

Bottom Line: In contrast, alcohol dependent patients persisted to the first established behavioral strategy.The mOFC-dorsal striatum functional connectivity was impaired in the alcohol-dependent patients, but increased in correlation with the duration of abstinence.Our findings support that the disruption of the mOFC-striatal circuitry contribute to the maldaptive persistent behaviors in alcohol dependent patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

ABSTRACT

Objective: Alcohol dependence is characterized by persistent alcohol-seeking despite negative consequences. Previous studies suggest that maladaptive persistent behaviors reflect alcohol-induced brain changes that cause alterations in the cortico-striatal-limbic circuit.

Methods: Twenty one alcohol dependent patients and 24 age-matched healthy controls performed a decision-making task during functional MRI. We defined the medial orbitofrontal cortex (mOFC) as a region-of-interest and performed seed-based functional connectivity analysis.

Results: Healthy controls were more flexible in adapting an alternative behavioral strategy, which correlated with stronger mOFC-dorsal striatum functional connectivity. In contrast, alcohol dependent patients persisted to the first established behavioral strategy. The mOFC-dorsal striatum functional connectivity was impaired in the alcohol-dependent patients, but increased in correlation with the duration of abstinence.

Conclusion: Our findings support that the disruption of the mOFC-striatal circuitry contribute to the maldaptive persistent behaviors in alcohol dependent patients.

No MeSH data available.


Related in: MedlinePlus