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Expression of hypoxia-related markers in inflammatory myofibroblastic tumors of the head and neck.

Wang KR, Jiang T, Wu TT, Zhou SH, Yao HT, Wang QY, Lu ZJ - World J Surg Oncol (2013)

Bottom Line: Univariate analyses revealed significant correlations between survival and GLUT-1 expression (P = 0.028), PI3K expression (P = 0.006), and p-Akt expression (P = 0.028).Multivariate analysis did not show a significant relationship between survival and GLUT-1, HIF-1α, PI3K, or p-Akt.Spearman rank correlation analysis showed significant correlations between HIF-1α and PI3K expression (r = 0.707, P = 0.01) and between p-Akt and PI3K expression (r = 0.837, P = 0.001).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China. zhouyunzhoush@163.com.

ABSTRACT

Background: The etiology of inflammatory myofibroblastic tumors (IMTs) is controversial and the prognosis is unpredictable. Previous studies have not investigated the expression of hypoxia-related markers in IMTs.

Methods: Between 2002 and 2012, 12 consecutive patients with histologically proven IMTs were enrolled in the study. Immunohistochemistry was used to detect GLUT-1, HIF-1α, PI3K, and p-Akt expression in paraffin-embedded tumor specimens. Associations among GLUT-1, HIF-1α, PI3K, and p-Akt protein expression and clinical parameters were investigated.

Results: The mean duration of follow-up was 52.1 months (range, 11 to 132 months). Six patients had local recurrence. GLUT-1, HIF-1α, PI3K, and p-Akt expression were detected in 41.7%, 50.0%, 33.3%, and 41.7% of patients, respectively. Fisher's exact test revealed significant correlations between recurrence of IMT and PI3K expression (P = 0.01) and p-Akt expression (P = 0.015). Univariate analyses revealed significant correlations between survival and GLUT-1 expression (P = 0.028), PI3K expression (P = 0.006), and p-Akt expression (P = 0.028). Multivariate analysis did not show a significant relationship between survival and GLUT-1, HIF-1α, PI3K, or p-Akt. Spearman rank correlation analysis showed significant correlations between HIF-1α and PI3K expression (r = 0.707, P = 0.01) and between p-Akt and PI3K expression (r = 0.837, P = 0.001).

Conclusions: Although our results are inconclusive owing to the small sample size, they suggest that PI3K and p-Akt expression may play a role in the recurrence of IMTs of the head and neck.

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Magnetic resonance imaging revealed a 1.3 × 2.2-cm mass in the right pyriform sinus. (A) Signals were isointense and slightly hypointense on the T1-weighted imaging, (B) hyperintense on T2-weighted imaging, and (C) heterogeneous enhancement was observed on the contrast-enhanced T1-weighted MRI images. (D) The patient underwent complete resection via a lateral neck incision and achieved a clear margin at second surgery.
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Figure 1: Magnetic resonance imaging revealed a 1.3 × 2.2-cm mass in the right pyriform sinus. (A) Signals were isointense and slightly hypointense on the T1-weighted imaging, (B) hyperintense on T2-weighted imaging, and (C) heterogeneous enhancement was observed on the contrast-enhanced T1-weighted MRI images. (D) The patient underwent complete resection via a lateral neck incision and achieved a clear margin at second surgery.

Mentions: Available IMT radiological images varied. CT, MRI, or FDG-PET/CT scans were available for nine patients. CT images were available for eight patients and showed homogenous (one case) or heterogeneous (seven cases) softtissue masses. Contrast-enhanced CT images were available for four patients: one case of IMT of the tonsil showed no enhancement, mild enhancement was found in one case of hypopharynx IMT, mild to moderate enhancement was detected in one of the maxillary sinus cases, and the IMT of the tongue showed strong enhancement. MRI data were available for two patients. In one patient, the T1-weighted signals were isointense and slightly hypointense and the T2-weighted signals were hyperintense. In the other patient, the T1 images were hyperintense and the T2 images were hypointense. The contrast-enhanced T1-weighted MRI images showed heterogeneous enhancement in both patients (Figure 1). FDG-PET/CT revealed FDG uptake in the left maxillary sinus (Figure 2A).


Expression of hypoxia-related markers in inflammatory myofibroblastic tumors of the head and neck.

Wang KR, Jiang T, Wu TT, Zhou SH, Yao HT, Wang QY, Lu ZJ - World J Surg Oncol (2013)

Magnetic resonance imaging revealed a 1.3 × 2.2-cm mass in the right pyriform sinus. (A) Signals were isointense and slightly hypointense on the T1-weighted imaging, (B) hyperintense on T2-weighted imaging, and (C) heterogeneous enhancement was observed on the contrast-enhanced T1-weighted MRI images. (D) The patient underwent complete resection via a lateral neck incision and achieved a clear margin at second surgery.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3842822&req=5

Figure 1: Magnetic resonance imaging revealed a 1.3 × 2.2-cm mass in the right pyriform sinus. (A) Signals were isointense and slightly hypointense on the T1-weighted imaging, (B) hyperintense on T2-weighted imaging, and (C) heterogeneous enhancement was observed on the contrast-enhanced T1-weighted MRI images. (D) The patient underwent complete resection via a lateral neck incision and achieved a clear margin at second surgery.
Mentions: Available IMT radiological images varied. CT, MRI, or FDG-PET/CT scans were available for nine patients. CT images were available for eight patients and showed homogenous (one case) or heterogeneous (seven cases) softtissue masses. Contrast-enhanced CT images were available for four patients: one case of IMT of the tonsil showed no enhancement, mild enhancement was found in one case of hypopharynx IMT, mild to moderate enhancement was detected in one of the maxillary sinus cases, and the IMT of the tongue showed strong enhancement. MRI data were available for two patients. In one patient, the T1-weighted signals were isointense and slightly hypointense and the T2-weighted signals were hyperintense. In the other patient, the T1 images were hyperintense and the T2 images were hypointense. The contrast-enhanced T1-weighted MRI images showed heterogeneous enhancement in both patients (Figure 1). FDG-PET/CT revealed FDG uptake in the left maxillary sinus (Figure 2A).

Bottom Line: Univariate analyses revealed significant correlations between survival and GLUT-1 expression (P = 0.028), PI3K expression (P = 0.006), and p-Akt expression (P = 0.028).Multivariate analysis did not show a significant relationship between survival and GLUT-1, HIF-1α, PI3K, or p-Akt.Spearman rank correlation analysis showed significant correlations between HIF-1α and PI3K expression (r = 0.707, P = 0.01) and between p-Akt and PI3K expression (r = 0.837, P = 0.001).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China. zhouyunzhoush@163.com.

ABSTRACT

Background: The etiology of inflammatory myofibroblastic tumors (IMTs) is controversial and the prognosis is unpredictable. Previous studies have not investigated the expression of hypoxia-related markers in IMTs.

Methods: Between 2002 and 2012, 12 consecutive patients with histologically proven IMTs were enrolled in the study. Immunohistochemistry was used to detect GLUT-1, HIF-1α, PI3K, and p-Akt expression in paraffin-embedded tumor specimens. Associations among GLUT-1, HIF-1α, PI3K, and p-Akt protein expression and clinical parameters were investigated.

Results: The mean duration of follow-up was 52.1 months (range, 11 to 132 months). Six patients had local recurrence. GLUT-1, HIF-1α, PI3K, and p-Akt expression were detected in 41.7%, 50.0%, 33.3%, and 41.7% of patients, respectively. Fisher's exact test revealed significant correlations between recurrence of IMT and PI3K expression (P = 0.01) and p-Akt expression (P = 0.015). Univariate analyses revealed significant correlations between survival and GLUT-1 expression (P = 0.028), PI3K expression (P = 0.006), and p-Akt expression (P = 0.028). Multivariate analysis did not show a significant relationship between survival and GLUT-1, HIF-1α, PI3K, or p-Akt. Spearman rank correlation analysis showed significant correlations between HIF-1α and PI3K expression (r = 0.707, P = 0.01) and between p-Akt and PI3K expression (r = 0.837, P = 0.001).

Conclusions: Although our results are inconclusive owing to the small sample size, they suggest that PI3K and p-Akt expression may play a role in the recurrence of IMTs of the head and neck.

Show MeSH
Related in: MedlinePlus