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Reliable set-up for in-loop ¹¹C-carboxylations using Grignard reactions for the preparation of [carbonyl-¹¹C]WAY-100635 and [¹¹C]-(+)-PHNO.

Rami-Mark C, Ungersboeck J, Haeusler D, Nics L, Philippe C, Mitterhauser M, Willeit M, Lanzenberger R, Karanikas G, Wadsak W - Appl Radiat Isot (2013)

Bottom Line: Aim of this work was the implementation of a generalized in-loop synthesis for (11)C-carboxylations and subsequent (11)C-acylations on the TRACERlab FxC Pro platform.The set-up was tested using [carbonyl-(11)C]WAY-100635 and, for the first time, [(11)C]-(+)-PHNO.Its general applicability could be demonstrated and both [carbonyl-(11)C]WAY-100635 and [(11)C]-(+)-PHNO were prepared with high reliability and satisfying outcome.

View Article: PubMed Central - PubMed

Affiliation: Radiochemistry and Biomarker Development Unit, Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria; Department of Inorganic Chemistry, University of Vienna, A-1090 Vienna, Austria.

No MeSH data available.


Chemical Structure of [11C]-(+)-PHNO and [carbonyl-11C]WAY 100635. ⁎ indicates the radioactive 11C atom.
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f0010: Chemical Structure of [11C]-(+)-PHNO and [carbonyl-11C]WAY 100635. ⁎ indicates the radioactive 11C atom.

Mentions: Since the in-loop method for 11C-carboxylation has originally been implemented on site for the preparation of [carbonyl-11C]WAY-100635 using a Nuclear Interface C11-methylation synthesizer modifications were necessary to translate the set-up to the TRACERlab FxC Pro platform now in use. Moreover, these modifications should enable the implementation of a generalized in-loop synthesis for 11C-carboxylations (Fig. 1). Its suitability was tested in the preparation of both [11C]-(+)-PHNO and [carbonyl-11C]WAY-100635 (Fig. 2).


Reliable set-up for in-loop ¹¹C-carboxylations using Grignard reactions for the preparation of [carbonyl-¹¹C]WAY-100635 and [¹¹C]-(+)-PHNO.

Rami-Mark C, Ungersboeck J, Haeusler D, Nics L, Philippe C, Mitterhauser M, Willeit M, Lanzenberger R, Karanikas G, Wadsak W - Appl Radiat Isot (2013)

Chemical Structure of [11C]-(+)-PHNO and [carbonyl-11C]WAY 100635. ⁎ indicates the radioactive 11C atom.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3842501&req=5

f0010: Chemical Structure of [11C]-(+)-PHNO and [carbonyl-11C]WAY 100635. ⁎ indicates the radioactive 11C atom.
Mentions: Since the in-loop method for 11C-carboxylation has originally been implemented on site for the preparation of [carbonyl-11C]WAY-100635 using a Nuclear Interface C11-methylation synthesizer modifications were necessary to translate the set-up to the TRACERlab FxC Pro platform now in use. Moreover, these modifications should enable the implementation of a generalized in-loop synthesis for 11C-carboxylations (Fig. 1). Its suitability was tested in the preparation of both [11C]-(+)-PHNO and [carbonyl-11C]WAY-100635 (Fig. 2).

Bottom Line: Aim of this work was the implementation of a generalized in-loop synthesis for (11)C-carboxylations and subsequent (11)C-acylations on the TRACERlab FxC Pro platform.The set-up was tested using [carbonyl-(11)C]WAY-100635 and, for the first time, [(11)C]-(+)-PHNO.Its general applicability could be demonstrated and both [carbonyl-(11)C]WAY-100635 and [(11)C]-(+)-PHNO were prepared with high reliability and satisfying outcome.

View Article: PubMed Central - PubMed

Affiliation: Radiochemistry and Biomarker Development Unit, Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria; Department of Inorganic Chemistry, University of Vienna, A-1090 Vienna, Austria.

No MeSH data available.