Gastroprotective effects of Corchorus olitorius leaf extract against ethanol-induced gastric mucosal hemorrhagic lesions in rats.
Bottom Line: In these groups, superoxide dismutase and malondialdehyde levels were significantly increased (P < 0.05) and reduced (P < 0.05), respectively.In addition to the histologic analyses (HE and periodic acid-Schiff staining), immunohistochemistry confirmed the protection through the upregulation of Hsp70 and the downregulation of Bax proteins.The gastroprotection of the experimental groups was comparable to that of the reference control medicine omeprazole.
Affiliation: Center of Studies for Periodontology, Faculty of Dentistry, University Technology Mara, Shah Alam, Selangor, Malaysia.Show MeSH
Related in: MedlinePlus
Mentions: The immunohistochemical results showed that the groups pretreated with C. olitorius extract had increased Hsp70 protein expression levels. Hsp70 protein expression in the ulcer control group was lower compared with the pretreated groups (Fig. 4).
Affiliation: Center of Studies for Periodontology, Faculty of Dentistry, University Technology Mara, Shah Alam, Selangor, Malaysia.