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Gastroprotective effects of Corchorus olitorius leaf extract against ethanol-induced gastric mucosal hemorrhagic lesions in rats.

Al Batran R, Al-Bayaty F, Abdulla MA, Al-Obaidi MM, Hajrezaei M, Hassandarvish P, Fouad M, Golbabapour S, Talaee S - J. Gastroenterol. Hepatol. (2013)

Bottom Line: In these groups, superoxide dismutase and malondialdehyde levels were significantly increased (P < 0.05) and reduced (P < 0.05), respectively.In addition to the histologic analyses (HE and periodic acid-Schiff staining), immunohistochemistry confirmed the protection through the upregulation of Hsp70 and the downregulation of Bax proteins.The gastroprotection of the experimental groups was comparable to that of the reference control medicine omeprazole.

View Article: PubMed Central - PubMed

Affiliation: Center of Studies for Periodontology, Faculty of Dentistry, University Technology Mara, Shah Alam, Selangor, Malaysia.

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Related in: MedlinePlus

Immunohistochemical analysis of Hsp70 expression in the gastric mucosa of rats (20×). (a) Normal control group. (b) The ulcer control group. (c) Omeprazole-treated group. (d, e, f and g) Groups pretreated with 50, 100, 200, and 400 mg/kg plant extract, respectively.
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fig04: Immunohistochemical analysis of Hsp70 expression in the gastric mucosa of rats (20×). (a) Normal control group. (b) The ulcer control group. (c) Omeprazole-treated group. (d, e, f and g) Groups pretreated with 50, 100, 200, and 400 mg/kg plant extract, respectively.

Mentions: The immunohistochemical results showed that the groups pretreated with C. olitorius extract had increased Hsp70 protein expression levels. Hsp70 protein expression in the ulcer control group was lower compared with the pretreated groups (Fig. 4).


Gastroprotective effects of Corchorus olitorius leaf extract against ethanol-induced gastric mucosal hemorrhagic lesions in rats.

Al Batran R, Al-Bayaty F, Abdulla MA, Al-Obaidi MM, Hajrezaei M, Hassandarvish P, Fouad M, Golbabapour S, Talaee S - J. Gastroenterol. Hepatol. (2013)

Immunohistochemical analysis of Hsp70 expression in the gastric mucosa of rats (20×). (a) Normal control group. (b) The ulcer control group. (c) Omeprazole-treated group. (d, e, f and g) Groups pretreated with 50, 100, 200, and 400 mg/kg plant extract, respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3842111&req=5

fig04: Immunohistochemical analysis of Hsp70 expression in the gastric mucosa of rats (20×). (a) Normal control group. (b) The ulcer control group. (c) Omeprazole-treated group. (d, e, f and g) Groups pretreated with 50, 100, 200, and 400 mg/kg plant extract, respectively.
Mentions: The immunohistochemical results showed that the groups pretreated with C. olitorius extract had increased Hsp70 protein expression levels. Hsp70 protein expression in the ulcer control group was lower compared with the pretreated groups (Fig. 4).

Bottom Line: In these groups, superoxide dismutase and malondialdehyde levels were significantly increased (P < 0.05) and reduced (P < 0.05), respectively.In addition to the histologic analyses (HE and periodic acid-Schiff staining), immunohistochemistry confirmed the protection through the upregulation of Hsp70 and the downregulation of Bax proteins.The gastroprotection of the experimental groups was comparable to that of the reference control medicine omeprazole.

View Article: PubMed Central - PubMed

Affiliation: Center of Studies for Periodontology, Faculty of Dentistry, University Technology Mara, Shah Alam, Selangor, Malaysia.

Show MeSH
Related in: MedlinePlus