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Gastroprotective effects of Corchorus olitorius leaf extract against ethanol-induced gastric mucosal hemorrhagic lesions in rats.

Al Batran R, Al-Bayaty F, Abdulla MA, Al-Obaidi MM, Hajrezaei M, Hassandarvish P, Fouad M, Golbabapour S, Talaee S - J. Gastroenterol. Hepatol. (2013)

Bottom Line: In these groups, superoxide dismutase and malondialdehyde levels were significantly increased (P < 0.05) and reduced (P < 0.05), respectively.In addition to the histologic analyses (HE and periodic acid-Schiff staining), immunohistochemistry confirmed the protection through the upregulation of Hsp70 and the downregulation of Bax proteins.The gastroprotection of the experimental groups was comparable to that of the reference control medicine omeprazole.

View Article: PubMed Central - PubMed

Affiliation: Center of Studies for Periodontology, Faculty of Dentistry, University Technology Mara, Shah Alam, Selangor, Malaysia.

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Related in: MedlinePlus

HE staining of the gastric tissue in rats (20×). (a) Normal control group. (b) Rats pretreated with carboxymethyl cellulose (CMC) (ulcer control). Disruption to the gastric epithelium, necrotic lesions penetrated deeply into the mucosa, extensive edema in the submucosal layer and leukocyte infiltration are apparent. (c) Rats pretreated with omeprazole (20 mg/kg). Mild disruption of the surface epithelium mucosa was present, but deep mucosal damage was absent. (d, e, f and g) The rats pretreated with 50, 100, 200, and 400 mg/kg Corchorus olitorius, respectively. There was no disruption to the surface epithelium and no edema or leukocyte infiltration into the submucosal layer.
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fig02: HE staining of the gastric tissue in rats (20×). (a) Normal control group. (b) Rats pretreated with carboxymethyl cellulose (CMC) (ulcer control). Disruption to the gastric epithelium, necrotic lesions penetrated deeply into the mucosa, extensive edema in the submucosal layer and leukocyte infiltration are apparent. (c) Rats pretreated with omeprazole (20 mg/kg). Mild disruption of the surface epithelium mucosa was present, but deep mucosal damage was absent. (d, e, f and g) The rats pretreated with 50, 100, 200, and 400 mg/kg Corchorus olitorius, respectively. There was no disruption to the surface epithelium and no edema or leukocyte infiltration into the submucosal layer.

Mentions: Histological analysis of ethanol-induced gastric mucosal lesions in the ulcer control group revealed substantial injuries to the gastric mucosa as well as edema and leukocyte infiltration into the submucosal layer. The rats pretreated with C. olitorius demonstrated significantly improved protection of the gastric mucosa with decreased total ulcer area, edema, and leukocyte infiltration into the submucosal layer (Fig. 2).


Gastroprotective effects of Corchorus olitorius leaf extract against ethanol-induced gastric mucosal hemorrhagic lesions in rats.

Al Batran R, Al-Bayaty F, Abdulla MA, Al-Obaidi MM, Hajrezaei M, Hassandarvish P, Fouad M, Golbabapour S, Talaee S - J. Gastroenterol. Hepatol. (2013)

HE staining of the gastric tissue in rats (20×). (a) Normal control group. (b) Rats pretreated with carboxymethyl cellulose (CMC) (ulcer control). Disruption to the gastric epithelium, necrotic lesions penetrated deeply into the mucosa, extensive edema in the submucosal layer and leukocyte infiltration are apparent. (c) Rats pretreated with omeprazole (20 mg/kg). Mild disruption of the surface epithelium mucosa was present, but deep mucosal damage was absent. (d, e, f and g) The rats pretreated with 50, 100, 200, and 400 mg/kg Corchorus olitorius, respectively. There was no disruption to the surface epithelium and no edema or leukocyte infiltration into the submucosal layer.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3842111&req=5

fig02: HE staining of the gastric tissue in rats (20×). (a) Normal control group. (b) Rats pretreated with carboxymethyl cellulose (CMC) (ulcer control). Disruption to the gastric epithelium, necrotic lesions penetrated deeply into the mucosa, extensive edema in the submucosal layer and leukocyte infiltration are apparent. (c) Rats pretreated with omeprazole (20 mg/kg). Mild disruption of the surface epithelium mucosa was present, but deep mucosal damage was absent. (d, e, f and g) The rats pretreated with 50, 100, 200, and 400 mg/kg Corchorus olitorius, respectively. There was no disruption to the surface epithelium and no edema or leukocyte infiltration into the submucosal layer.
Mentions: Histological analysis of ethanol-induced gastric mucosal lesions in the ulcer control group revealed substantial injuries to the gastric mucosa as well as edema and leukocyte infiltration into the submucosal layer. The rats pretreated with C. olitorius demonstrated significantly improved protection of the gastric mucosa with decreased total ulcer area, edema, and leukocyte infiltration into the submucosal layer (Fig. 2).

Bottom Line: In these groups, superoxide dismutase and malondialdehyde levels were significantly increased (P < 0.05) and reduced (P < 0.05), respectively.In addition to the histologic analyses (HE and periodic acid-Schiff staining), immunohistochemistry confirmed the protection through the upregulation of Hsp70 and the downregulation of Bax proteins.The gastroprotection of the experimental groups was comparable to that of the reference control medicine omeprazole.

View Article: PubMed Central - PubMed

Affiliation: Center of Studies for Periodontology, Faculty of Dentistry, University Technology Mara, Shah Alam, Selangor, Malaysia.

Show MeSH
Related in: MedlinePlus