Gastroprotective effects of Corchorus olitorius leaf extract against ethanol-induced gastric mucosal hemorrhagic lesions in rats.
Bottom Line: In these groups, superoxide dismutase and malondialdehyde levels were significantly increased (P < 0.05) and reduced (P < 0.05), respectively.In addition to the histologic analyses (HE and periodic acid-Schiff staining), immunohistochemistry confirmed the protection through the upregulation of Hsp70 and the downregulation of Bax proteins.The gastroprotection of the experimental groups was comparable to that of the reference control medicine omeprazole.
Affiliation: Center of Studies for Periodontology, Faculty of Dentistry, University Technology Mara, Shah Alam, Selangor, Malaysia.Show MeSH
Related in: MedlinePlus
Mentions: Histological analysis of ethanol-induced gastric mucosal lesions in the ulcer control group revealed substantial injuries to the gastric mucosa as well as edema and leukocyte infiltration into the submucosal layer. The rats pretreated with C. olitorius demonstrated significantly improved protection of the gastric mucosa with decreased total ulcer area, edema, and leukocyte infiltration into the submucosal layer (Fig. 2).
Affiliation: Center of Studies for Periodontology, Faculty of Dentistry, University Technology Mara, Shah Alam, Selangor, Malaysia.