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The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease.

Mogilyansky E, Rigoutsos I - Cell Death Differ. (2013)

Bottom Line: The miR-17/92 cluster is among the best-studied microRNA clusters.Interest in the cluster and its members has been increasing steadily and the number of publications has grown exponentially since its discovery with more than 1000 articles published in 2012 alone.In light of its ever-increasing importance and ever-widening regulatory roles, we review here the latest body of knowledge on the cluster's involvement in health and disease as well as provide a novel perspective on the full spectrum of protein-coding and non-coding transcripts that are likely regulated by its members.

View Article: PubMed Central - PubMed

Affiliation: Computational Medicine Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

ABSTRACT
The miR-17/92 cluster is among the best-studied microRNA clusters. Interest in the cluster and its members has been increasing steadily and the number of publications has grown exponentially since its discovery with more than 1000 articles published in 2012 alone. Originally found to be involved in tumorigenesis, research work in recent years has uncovered unexpected roles for its members in a wide variety of settings that include normal development, immune diseases, cardiovascular diseases, neurodegenerative diseases and aging. In light of its ever-increasing importance and ever-widening regulatory roles, we review here the latest body of knowledge on the cluster's involvement in health and disease as well as provide a novel perspective on the full spectrum of protein-coding and non-coding transcripts that are likely regulated by its members.

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Related in: MedlinePlus

Members of the miR-17/92 cluster and its two paralogues miR-106a/363 and miR-106b/25 and their chromosomal location. Red: members of the miR-17 family; blue: members of the miR-18 family; green: members of the miR-19 family; orange: members of the miR-92 family
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fig2: Members of the miR-17/92 cluster and its two paralogues miR-106a/363 and miR-106b/25 and their chromosomal location. Red: members of the miR-17 family; blue: members of the miR-18 family; green: members of the miR-19 family; orange: members of the miR-92 family

Mentions: The human genome contains two paralogues of the main cluster (Figure 2): the miR-106b/25 and the miR-106a/363 cluster, respectively. MiR-106b/25 is located on chromosome 7 (7q22.1), in the 13th intron of the MCM7 gene. MiR-106a/363 is located on chromosome X (Xq26.2). The miR-106b/25 cluster comprises three miRNAs: miR-106b, miR-93 and miR-25 (Figure 2). The miR-106a/363 cluster comprises six miRNAs: miR-106a, miR-18b, miR-20b, miR-19b-2, miR-92a-2 and miR-363. MiR-17/92 and miR-106b/25 are expressed abundantly in a wide spectrum of tissues but miR-106a/363 is expressed at lower levels.14, 15 Together these three miRNA clusters represent a combined total of 15 miRNAs that form four ‘seed' families: the miR-17 family, the miR-18 family, the miR-19 family and the miR-92 family (Figure 3).


The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease.

Mogilyansky E, Rigoutsos I - Cell Death Differ. (2013)

Members of the miR-17/92 cluster and its two paralogues miR-106a/363 and miR-106b/25 and their chromosomal location. Red: members of the miR-17 family; blue: members of the miR-18 family; green: members of the miR-19 family; orange: members of the miR-92 family
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3824591&req=5

fig2: Members of the miR-17/92 cluster and its two paralogues miR-106a/363 and miR-106b/25 and their chromosomal location. Red: members of the miR-17 family; blue: members of the miR-18 family; green: members of the miR-19 family; orange: members of the miR-92 family
Mentions: The human genome contains two paralogues of the main cluster (Figure 2): the miR-106b/25 and the miR-106a/363 cluster, respectively. MiR-106b/25 is located on chromosome 7 (7q22.1), in the 13th intron of the MCM7 gene. MiR-106a/363 is located on chromosome X (Xq26.2). The miR-106b/25 cluster comprises three miRNAs: miR-106b, miR-93 and miR-25 (Figure 2). The miR-106a/363 cluster comprises six miRNAs: miR-106a, miR-18b, miR-20b, miR-19b-2, miR-92a-2 and miR-363. MiR-17/92 and miR-106b/25 are expressed abundantly in a wide spectrum of tissues but miR-106a/363 is expressed at lower levels.14, 15 Together these three miRNA clusters represent a combined total of 15 miRNAs that form four ‘seed' families: the miR-17 family, the miR-18 family, the miR-19 family and the miR-92 family (Figure 3).

Bottom Line: The miR-17/92 cluster is among the best-studied microRNA clusters.Interest in the cluster and its members has been increasing steadily and the number of publications has grown exponentially since its discovery with more than 1000 articles published in 2012 alone.In light of its ever-increasing importance and ever-widening regulatory roles, we review here the latest body of knowledge on the cluster's involvement in health and disease as well as provide a novel perspective on the full spectrum of protein-coding and non-coding transcripts that are likely regulated by its members.

View Article: PubMed Central - PubMed

Affiliation: Computational Medicine Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

ABSTRACT
The miR-17/92 cluster is among the best-studied microRNA clusters. Interest in the cluster and its members has been increasing steadily and the number of publications has grown exponentially since its discovery with more than 1000 articles published in 2012 alone. Originally found to be involved in tumorigenesis, research work in recent years has uncovered unexpected roles for its members in a wide variety of settings that include normal development, immune diseases, cardiovascular diseases, neurodegenerative diseases and aging. In light of its ever-increasing importance and ever-widening regulatory roles, we review here the latest body of knowledge on the cluster's involvement in health and disease as well as provide a novel perspective on the full spectrum of protein-coding and non-coding transcripts that are likely regulated by its members.

Show MeSH
Related in: MedlinePlus