Limits...
FGF21 drives a shift in adipokine tone to restore metabolic health.

Adams AC, Kharitonenkov A - Aging (Albany NY) (2013)

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Of critical importance, acute FGF21 signaling is not compromised in Adn−/− mice when compared to their WT counterparts... However, only in WT animals with intact adiponectin signaling is FGF21 able to trigger a cascade of metabolic events leading to correction of hyperglycemia and hyperinsulinemia... Correlated with the lack of improvement in glycemia and insulin sensitivity there was also lack of ceramide lowering in FGF21 treated Adn−/− animals... Supportive of partitioning of FGF21s metabolic endpoints, weight loss, elevated energy expenditure and reduced circulating lipids were yet evident FGF21-treated Adn−/− mice... Of note, induction of adiponectin is also a hallmark of another class of anti-diabetic therapeutics, the thiazoladinediones... In concordance with this hypothesis, upon administration of either FGF21 or PPARγ ligands elevation of serum adiponectin reaches similar levels in mice... Nevertheless, TZDs mainly impact transcription of adiponectin gene while FGF21 functions as a potent adiponectin secretagogue... Furthermore, it has also recently been reported that in vivo the FGF21 & PPARγ pathways do not in fact intersect... These distinctions are important in reconciling the lack of rosiglitazone-associated side effects such as adipose accrual and elevation of liver enzymes in FGF21 treated mice... Further work delineating additional downstream mediators of FGF21 action in adipose and other tissues will be critical to understanding of its mechanism of action and thus potentially yielding novel therapeutic avenues.

Show MeSH
Effects of chronic FGF21 treatment in vivo are mediated by specific hormonal pathways downstream of adipose tissue activation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3824405&req=5

Figure 1: Effects of chronic FGF21 treatment in vivo are mediated by specific hormonal pathways downstream of adipose tissue activation.


FGF21 drives a shift in adipokine tone to restore metabolic health.

Adams AC, Kharitonenkov A - Aging (Albany NY) (2013)

Effects of chronic FGF21 treatment in vivo are mediated by specific hormonal pathways downstream of adipose tissue activation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3824405&req=5

Figure 1: Effects of chronic FGF21 treatment in vivo are mediated by specific hormonal pathways downstream of adipose tissue activation.

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Of critical importance, acute FGF21 signaling is not compromised in Adn−/− mice when compared to their WT counterparts... However, only in WT animals with intact adiponectin signaling is FGF21 able to trigger a cascade of metabolic events leading to correction of hyperglycemia and hyperinsulinemia... Correlated with the lack of improvement in glycemia and insulin sensitivity there was also lack of ceramide lowering in FGF21 treated Adn−/− animals... Supportive of partitioning of FGF21s metabolic endpoints, weight loss, elevated energy expenditure and reduced circulating lipids were yet evident FGF21-treated Adn−/− mice... Of note, induction of adiponectin is also a hallmark of another class of anti-diabetic therapeutics, the thiazoladinediones... In concordance with this hypothesis, upon administration of either FGF21 or PPARγ ligands elevation of serum adiponectin reaches similar levels in mice... Nevertheless, TZDs mainly impact transcription of adiponectin gene while FGF21 functions as a potent adiponectin secretagogue... Furthermore, it has also recently been reported that in vivo the FGF21 & PPARγ pathways do not in fact intersect... These distinctions are important in reconciling the lack of rosiglitazone-associated side effects such as adipose accrual and elevation of liver enzymes in FGF21 treated mice... Further work delineating additional downstream mediators of FGF21 action in adipose and other tissues will be critical to understanding of its mechanism of action and thus potentially yielding novel therapeutic avenues.

Show MeSH