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Tissue kidney injury molecule-1 expression in the prediction of renal function for several years after kidney biopsy.

Simic Ogrizovic S, Bojic S, Basta-Jovanovic G, Radojevic S, Pavlovic J, Kotur Stevuljevic J, Dopsaj V, Naumovic R - Dis. Markers (2013)

Bottom Line: Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later.Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (P = 0.016) was a predictor only at 6 months after biopsy.Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest.

View Article: PubMed Central - PubMed

Affiliation: Clinic of Nephrology, Clinical Center of Serbia, Pasterova 2, 11 000 Belgrade, Serbia ; School of Medicine, University of Belgrade, Serbia.

ABSTRACT

Objectives: Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 ± 12.23 years with different kidney diseases over three years after kidney biopsy.

Materials and methods: Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later.

Results: Significantly positive correlations between tissue KIM-1 expression and age (r = 0.313), TIN inflammation (r = 0.456), fibrosis (r = 0.317), and proteinuria at 6 months (r = 0.394) as well as negative correlations with GFR0 (r = -0.572), GFR6 (r = -0.442), GFR24 (r = -0.398), and GFR36 (r = -0.412) were found. Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (P = 0.016) was a predictor only at 6 months after biopsy.

Conclusion: Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest.

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Related in: MedlinePlus

Linear correlation between TIN inflammation (P = 0.000), tissue KIM-1 expression (P = 0.000), and eGFR 6 months after kidney biopsy.
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fig2: Linear correlation between TIN inflammation (P = 0.000), tissue KIM-1 expression (P = 0.000), and eGFR 6 months after kidney biopsy.

Mentions: Table 3 gives the correlation coefficients between eGFR at the time of biopsy and 6, 12, 24, and 36 months later and the examined variables. Multivariant stepwise regression analysis showed that the best predictor of kidney function at the time of biopsy (eGFR 0) was TIN inflammation (P < 0.001), as well as of eGFR12 (P = 0.015), eGFR 24 (P = 0.039), and eGFR 36 (P = 0.012). However tissue KIM-1 expression was the best predictor of eGFR 6 (P = 0.016) along with TIN inflammation (P = 0.016) (Table 4). Figure 2 presents the linear correlation between TIN inflammation (P < 0.001), tissue KIM-1 expression (P < 0.001), and eGFR 6.


Tissue kidney injury molecule-1 expression in the prediction of renal function for several years after kidney biopsy.

Simic Ogrizovic S, Bojic S, Basta-Jovanovic G, Radojevic S, Pavlovic J, Kotur Stevuljevic J, Dopsaj V, Naumovic R - Dis. Markers (2013)

Linear correlation between TIN inflammation (P = 0.000), tissue KIM-1 expression (P = 0.000), and eGFR 6 months after kidney biopsy.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3824354&req=5

fig2: Linear correlation between TIN inflammation (P = 0.000), tissue KIM-1 expression (P = 0.000), and eGFR 6 months after kidney biopsy.
Mentions: Table 3 gives the correlation coefficients between eGFR at the time of biopsy and 6, 12, 24, and 36 months later and the examined variables. Multivariant stepwise regression analysis showed that the best predictor of kidney function at the time of biopsy (eGFR 0) was TIN inflammation (P < 0.001), as well as of eGFR12 (P = 0.015), eGFR 24 (P = 0.039), and eGFR 36 (P = 0.012). However tissue KIM-1 expression was the best predictor of eGFR 6 (P = 0.016) along with TIN inflammation (P = 0.016) (Table 4). Figure 2 presents the linear correlation between TIN inflammation (P < 0.001), tissue KIM-1 expression (P < 0.001), and eGFR 6.

Bottom Line: Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later.Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (P = 0.016) was a predictor only at 6 months after biopsy.Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest.

View Article: PubMed Central - PubMed

Affiliation: Clinic of Nephrology, Clinical Center of Serbia, Pasterova 2, 11 000 Belgrade, Serbia ; School of Medicine, University of Belgrade, Serbia.

ABSTRACT

Objectives: Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 ± 12.23 years with different kidney diseases over three years after kidney biopsy.

Materials and methods: Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later.

Results: Significantly positive correlations between tissue KIM-1 expression and age (r = 0.313), TIN inflammation (r = 0.456), fibrosis (r = 0.317), and proteinuria at 6 months (r = 0.394) as well as negative correlations with GFR0 (r = -0.572), GFR6 (r = -0.442), GFR24 (r = -0.398), and GFR36 (r = -0.412) were found. Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (P = 0.016) was a predictor only at 6 months after biopsy.

Conclusion: Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest.

Show MeSH
Related in: MedlinePlus