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Implication of low HDL-c levels in patients with average LDL-c levels: a focus on oxidized LDL, large HDL subpopulation, and adiponectin.

Mascarenhas-Melo F, Sereno J, Teixeira-Lemos E, Marado D, Palavra F, Pinto R, Rocha-Pereira P, Teixeira F, Reis F - Mediators Inflamm. (2013)

Bottom Line: To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles.However, differences in patients' subgroups were clearly more pronounced.In conclusion, despite LDL-c average levels, low HDL-c concentrations seem to be associated with a poor cardiometabolic profile in a population with cardiovascular risk factors, which is better evidenced by traditional and nontraditional CV biomarkers, including Ox-LDL, large HDL-c, and adiponectin.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (Pólo III), University of Coimbra, 3000-548 Coimbra, Portugal.

ABSTRACT
To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles. Patients with cardiovascular risk factors (n = 169) and control subjects (n = 73) were divided into 2 subgroups, one of normal HDL-c and the other of low HDL-c levels. The following data was analyzed: BP, BMI, waist circumference and serum glucose Total-c, TGs, LDL-c, oxidized LDL, total HDL-c and subpopulations (small, intermediate, and large), paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF- α , adiponectin, VEGF, and iCAM1. In the control subgroup with low HDL-c levels, significantly higher values of BP and TGs and lower values of PON1 activity and adiponectin were found, versus control normal HDL-c subgroup. However, differences in patients' subgroups were clearly more pronounced. Indeed, low HDL-c subgroup presented increased HbA1c, TGs, non-HDL-c, Ox-LDL, hsCRP, VEGF, and small HDL-c and reduced adiponectin and large HDL. In addition, Ox-LDL, large-HDL-c, and adiponectin presented interesting correlations with classical and nonclassical markers, mainly in the normal HDL-c patients' subgroup. In conclusion, despite LDL-c average levels, low HDL-c concentrations seem to be associated with a poor cardiometabolic profile in a population with cardiovascular risk factors, which is better evidenced by traditional and nontraditional CV biomarkers, including Ox-LDL, large HDL-c, and adiponectin.

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Main correlations in normal and low-HDL-c patients. Correlation between adiponectin and large HDL-c (a), small HDL-c (b), TGs (c), waist circumference (d), hsCRP (e), and uric acid (f).
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fig5: Main correlations in normal and low-HDL-c patients. Correlation between adiponectin and large HDL-c (a), small HDL-c (b), TGs (c), waist circumference (d), hsCRP (e), and uric acid (f).

Mentions: The values of large-HDL in the normal HDL-c patients' subgroup were negatively and significantly correlated with Ox-LDL (r = −0.355, P = 0.000) (Figure 3(a)), LDL-c (r = −0.696, P = 0.000) (Figure 3(b)), non-HDL-c (r = −0.348, P = 0.000) (Figure 3(c)), TNF-α (r = −0.198, P = 0.049) (Figure 3(e)), and TGs (r = −0.336, P = 0.000) (Figure 3(f)) levels and positively and significantly correlated with adiponectin (r = 0.173, P = 0.046) (Figure 3(d)) but not in the low-HDL-c patients' subgroup (versus Ox-LDL: r = −0.215, P = 0.172; versus LDL-c: r = −0.175, P = 0.235; versus non-HDL-c: r = −0.209, P = 0.149; versus adiponectin: r = 0.129, P = 0.429; versus TNF-α: r = 0.117, P = 0.460; versus TGs: r = −0.045, P = 0.758) (Figure 3(a) to Figure 3(f), resp.). In addition, in the normal HDL-c patients' subgroup, Ox-LDL was negatively and significantly correlated with large HDL-c (r = −0.355, P = 0.000) (Figure 4(a)) and positively and significantly correlated with small HDL-c (r = 0.437, P = 0.000) (Figure 4(b)), TNF-α (r = 0.235, P = 0.019) (Figure 4(d)), DBP (r = 0.314, P = 0.001) (Figure 4(e)), and TGs (r = 0.307, P = 0.002) (Figure 4(f)), together with a trend to correlation with PON1 activity (r = 0.179, P = 0.072) (Figure 4(c)). These correlations showed statistically unchanged values in the low HDL-c patients' subgroup (versus large HDL-c: r = −0.215, P = 0.172; versus small HDL-c: r = 0.121, P = 0.444; versus PON1 activity: r = 0.237, P = 0.131; versus TNF-α: r = −0.095, P = 0.551; versus DBP: r = 0.222, P = 0.157; versus TGs: r = 0.092, P = 0.569) (Figure 4(a) to Figure 4(f), resp.). Finally, also in normal-HDL-c patients' subgroup, adiponectin was positively and significantly correlated with large HDL-c (r = 0.363, P = 0.000) (Figure 5(a)) and negatively and significantly correlated with TGs (r = −0.235, P = 0.019) (Figure 5(c)), waist circumference (r = −0.320, P = 0.002) (Figure 5(d)), hsCRP (r = −0.268, P = 0.042) (Figure 5(e)), and uric acid (r = −0.376, P = 0.002) (Figure 5(f)) but not in low HDL-c patients' subgroup (with the exception of TGs and uric acid) (versus large HDL-c: r = 0.240, P = 0.136; versus TGs: r = −0.410, P = 0.010; versus waist circumference: r = −0.232, P = 0.180; versus hsCRP: r = 0.037, P = 0.852; versus uric acid: r = −0.423, P = 0.028, resp.) (Figure 5). In opposition with large HDL-c, no significant correlation was found between adiponectin and small HDL-c in both normal (r = −0.048, P = 0.637) and low HDL-c (r = −0.049, P = 0.763) patients' subgroups (Figure 5(b)).


Implication of low HDL-c levels in patients with average LDL-c levels: a focus on oxidized LDL, large HDL subpopulation, and adiponectin.

Mascarenhas-Melo F, Sereno J, Teixeira-Lemos E, Marado D, Palavra F, Pinto R, Rocha-Pereira P, Teixeira F, Reis F - Mediators Inflamm. (2013)

Main correlations in normal and low-HDL-c patients. Correlation between adiponectin and large HDL-c (a), small HDL-c (b), TGs (c), waist circumference (d), hsCRP (e), and uric acid (f).
© Copyright Policy - open-access
Related In: Results  -  Collection

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fig5: Main correlations in normal and low-HDL-c patients. Correlation between adiponectin and large HDL-c (a), small HDL-c (b), TGs (c), waist circumference (d), hsCRP (e), and uric acid (f).
Mentions: The values of large-HDL in the normal HDL-c patients' subgroup were negatively and significantly correlated with Ox-LDL (r = −0.355, P = 0.000) (Figure 3(a)), LDL-c (r = −0.696, P = 0.000) (Figure 3(b)), non-HDL-c (r = −0.348, P = 0.000) (Figure 3(c)), TNF-α (r = −0.198, P = 0.049) (Figure 3(e)), and TGs (r = −0.336, P = 0.000) (Figure 3(f)) levels and positively and significantly correlated with adiponectin (r = 0.173, P = 0.046) (Figure 3(d)) but not in the low-HDL-c patients' subgroup (versus Ox-LDL: r = −0.215, P = 0.172; versus LDL-c: r = −0.175, P = 0.235; versus non-HDL-c: r = −0.209, P = 0.149; versus adiponectin: r = 0.129, P = 0.429; versus TNF-α: r = 0.117, P = 0.460; versus TGs: r = −0.045, P = 0.758) (Figure 3(a) to Figure 3(f), resp.). In addition, in the normal HDL-c patients' subgroup, Ox-LDL was negatively and significantly correlated with large HDL-c (r = −0.355, P = 0.000) (Figure 4(a)) and positively and significantly correlated with small HDL-c (r = 0.437, P = 0.000) (Figure 4(b)), TNF-α (r = 0.235, P = 0.019) (Figure 4(d)), DBP (r = 0.314, P = 0.001) (Figure 4(e)), and TGs (r = 0.307, P = 0.002) (Figure 4(f)), together with a trend to correlation with PON1 activity (r = 0.179, P = 0.072) (Figure 4(c)). These correlations showed statistically unchanged values in the low HDL-c patients' subgroup (versus large HDL-c: r = −0.215, P = 0.172; versus small HDL-c: r = 0.121, P = 0.444; versus PON1 activity: r = 0.237, P = 0.131; versus TNF-α: r = −0.095, P = 0.551; versus DBP: r = 0.222, P = 0.157; versus TGs: r = 0.092, P = 0.569) (Figure 4(a) to Figure 4(f), resp.). Finally, also in normal-HDL-c patients' subgroup, adiponectin was positively and significantly correlated with large HDL-c (r = 0.363, P = 0.000) (Figure 5(a)) and negatively and significantly correlated with TGs (r = −0.235, P = 0.019) (Figure 5(c)), waist circumference (r = −0.320, P = 0.002) (Figure 5(d)), hsCRP (r = −0.268, P = 0.042) (Figure 5(e)), and uric acid (r = −0.376, P = 0.002) (Figure 5(f)) but not in low HDL-c patients' subgroup (with the exception of TGs and uric acid) (versus large HDL-c: r = 0.240, P = 0.136; versus TGs: r = −0.410, P = 0.010; versus waist circumference: r = −0.232, P = 0.180; versus hsCRP: r = 0.037, P = 0.852; versus uric acid: r = −0.423, P = 0.028, resp.) (Figure 5). In opposition with large HDL-c, no significant correlation was found between adiponectin and small HDL-c in both normal (r = −0.048, P = 0.637) and low HDL-c (r = −0.049, P = 0.763) patients' subgroups (Figure 5(b)).

Bottom Line: To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles.However, differences in patients' subgroups were clearly more pronounced.In conclusion, despite LDL-c average levels, low HDL-c concentrations seem to be associated with a poor cardiometabolic profile in a population with cardiovascular risk factors, which is better evidenced by traditional and nontraditional CV biomarkers, including Ox-LDL, large HDL-c, and adiponectin.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (Pólo III), University of Coimbra, 3000-548 Coimbra, Portugal.

ABSTRACT
To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles. Patients with cardiovascular risk factors (n = 169) and control subjects (n = 73) were divided into 2 subgroups, one of normal HDL-c and the other of low HDL-c levels. The following data was analyzed: BP, BMI, waist circumference and serum glucose Total-c, TGs, LDL-c, oxidized LDL, total HDL-c and subpopulations (small, intermediate, and large), paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF- α , adiponectin, VEGF, and iCAM1. In the control subgroup with low HDL-c levels, significantly higher values of BP and TGs and lower values of PON1 activity and adiponectin were found, versus control normal HDL-c subgroup. However, differences in patients' subgroups were clearly more pronounced. Indeed, low HDL-c subgroup presented increased HbA1c, TGs, non-HDL-c, Ox-LDL, hsCRP, VEGF, and small HDL-c and reduced adiponectin and large HDL. In addition, Ox-LDL, large-HDL-c, and adiponectin presented interesting correlations with classical and nonclassical markers, mainly in the normal HDL-c patients' subgroup. In conclusion, despite LDL-c average levels, low HDL-c concentrations seem to be associated with a poor cardiometabolic profile in a population with cardiovascular risk factors, which is better evidenced by traditional and nontraditional CV biomarkers, including Ox-LDL, large HDL-c, and adiponectin.

Show MeSH
Related in: MedlinePlus