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Implication of low HDL-c levels in patients with average LDL-c levels: a focus on oxidized LDL, large HDL subpopulation, and adiponectin.

Mascarenhas-Melo F, Sereno J, Teixeira-Lemos E, Marado D, Palavra F, Pinto R, Rocha-Pereira P, Teixeira F, Reis F - Mediators Inflamm. (2013)

Bottom Line: To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles.However, differences in patients' subgroups were clearly more pronounced.In conclusion, despite LDL-c average levels, low HDL-c concentrations seem to be associated with a poor cardiometabolic profile in a population with cardiovascular risk factors, which is better evidenced by traditional and nontraditional CV biomarkers, including Ox-LDL, large HDL-c, and adiponectin.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (Pólo III), University of Coimbra, 3000-548 Coimbra, Portugal.

ABSTRACT
To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles. Patients with cardiovascular risk factors (n = 169) and control subjects (n = 73) were divided into 2 subgroups, one of normal HDL-c and the other of low HDL-c levels. The following data was analyzed: BP, BMI, waist circumference and serum glucose Total-c, TGs, LDL-c, oxidized LDL, total HDL-c and subpopulations (small, intermediate, and large), paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF- α , adiponectin, VEGF, and iCAM1. In the control subgroup with low HDL-c levels, significantly higher values of BP and TGs and lower values of PON1 activity and adiponectin were found, versus control normal HDL-c subgroup. However, differences in patients' subgroups were clearly more pronounced. Indeed, low HDL-c subgroup presented increased HbA1c, TGs, non-HDL-c, Ox-LDL, hsCRP, VEGF, and small HDL-c and reduced adiponectin and large HDL. In addition, Ox-LDL, large-HDL-c, and adiponectin presented interesting correlations with classical and nonclassical markers, mainly in the normal HDL-c patients' subgroup. In conclusion, despite LDL-c average levels, low HDL-c concentrations seem to be associated with a poor cardiometabolic profile in a population with cardiovascular risk factors, which is better evidenced by traditional and nontraditional CV biomarkers, including Ox-LDL, large HDL-c, and adiponectin.

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Related in: MedlinePlus

Serum adiponectin (a), VEGF (b), and hsCRP (c) levels, in the study groups. Results are presented as mean ± SEM. *P < 0.05 and **P < 0.01.
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fig2: Serum adiponectin (a), VEGF (b), and hsCRP (c) levels, in the study groups. Results are presented as mean ± SEM. *P < 0.05 and **P < 0.01.

Mentions: Regarding other putative markers of cardiovascular disease, in the control individuals, the reduced content of HDL-c was associated only with a significantly reduced concentration of adiponectin (Figure 2(a)), when compared with controls subjects with normal HDL-c levels; all the other parameters were unchanged, including hsCRP, TNF-α, uric acid, iCAM-1, and VEGF (Table 2 and Figure 2). However, in the patients' population, the reduced content of HDL-c was associated not only with an additional reduction of adiponectin (Figure 2(a)) but also with significantly increased concentrations of VEGF and hsCRP (Figures 2(b) and 2(c), resp.), when compared with patient subgroup with normal HDL-c levels (Table 2 and Figure 2).


Implication of low HDL-c levels in patients with average LDL-c levels: a focus on oxidized LDL, large HDL subpopulation, and adiponectin.

Mascarenhas-Melo F, Sereno J, Teixeira-Lemos E, Marado D, Palavra F, Pinto R, Rocha-Pereira P, Teixeira F, Reis F - Mediators Inflamm. (2013)

Serum adiponectin (a), VEGF (b), and hsCRP (c) levels, in the study groups. Results are presented as mean ± SEM. *P < 0.05 and **P < 0.01.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3824339&req=5

fig2: Serum adiponectin (a), VEGF (b), and hsCRP (c) levels, in the study groups. Results are presented as mean ± SEM. *P < 0.05 and **P < 0.01.
Mentions: Regarding other putative markers of cardiovascular disease, in the control individuals, the reduced content of HDL-c was associated only with a significantly reduced concentration of adiponectin (Figure 2(a)), when compared with controls subjects with normal HDL-c levels; all the other parameters were unchanged, including hsCRP, TNF-α, uric acid, iCAM-1, and VEGF (Table 2 and Figure 2). However, in the patients' population, the reduced content of HDL-c was associated not only with an additional reduction of adiponectin (Figure 2(a)) but also with significantly increased concentrations of VEGF and hsCRP (Figures 2(b) and 2(c), resp.), when compared with patient subgroup with normal HDL-c levels (Table 2 and Figure 2).

Bottom Line: To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles.However, differences in patients' subgroups were clearly more pronounced.In conclusion, despite LDL-c average levels, low HDL-c concentrations seem to be associated with a poor cardiometabolic profile in a population with cardiovascular risk factors, which is better evidenced by traditional and nontraditional CV biomarkers, including Ox-LDL, large HDL-c, and adiponectin.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (Pólo III), University of Coimbra, 3000-548 Coimbra, Portugal.

ABSTRACT
To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles. Patients with cardiovascular risk factors (n = 169) and control subjects (n = 73) were divided into 2 subgroups, one of normal HDL-c and the other of low HDL-c levels. The following data was analyzed: BP, BMI, waist circumference and serum glucose Total-c, TGs, LDL-c, oxidized LDL, total HDL-c and subpopulations (small, intermediate, and large), paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF- α , adiponectin, VEGF, and iCAM1. In the control subgroup with low HDL-c levels, significantly higher values of BP and TGs and lower values of PON1 activity and adiponectin were found, versus control normal HDL-c subgroup. However, differences in patients' subgroups were clearly more pronounced. Indeed, low HDL-c subgroup presented increased HbA1c, TGs, non-HDL-c, Ox-LDL, hsCRP, VEGF, and small HDL-c and reduced adiponectin and large HDL. In addition, Ox-LDL, large-HDL-c, and adiponectin presented interesting correlations with classical and nonclassical markers, mainly in the normal HDL-c patients' subgroup. In conclusion, despite LDL-c average levels, low HDL-c concentrations seem to be associated with a poor cardiometabolic profile in a population with cardiovascular risk factors, which is better evidenced by traditional and nontraditional CV biomarkers, including Ox-LDL, large HDL-c, and adiponectin.

Show MeSH
Related in: MedlinePlus