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Implication of low HDL-c levels in patients with average LDL-c levels: a focus on oxidized LDL, large HDL subpopulation, and adiponectin.

Mascarenhas-Melo F, Sereno J, Teixeira-Lemos E, Marado D, Palavra F, Pinto R, Rocha-Pereira P, Teixeira F, Reis F - Mediators Inflamm. (2013)

Bottom Line: To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles.However, differences in patients' subgroups were clearly more pronounced.In conclusion, despite LDL-c average levels, low HDL-c concentrations seem to be associated with a poor cardiometabolic profile in a population with cardiovascular risk factors, which is better evidenced by traditional and nontraditional CV biomarkers, including Ox-LDL, large HDL-c, and adiponectin.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (Pólo III), University of Coimbra, 3000-548 Coimbra, Portugal.

ABSTRACT
To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles. Patients with cardiovascular risk factors (n = 169) and control subjects (n = 73) were divided into 2 subgroups, one of normal HDL-c and the other of low HDL-c levels. The following data was analyzed: BP, BMI, waist circumference and serum glucose Total-c, TGs, LDL-c, oxidized LDL, total HDL-c and subpopulations (small, intermediate, and large), paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF- α , adiponectin, VEGF, and iCAM1. In the control subgroup with low HDL-c levels, significantly higher values of BP and TGs and lower values of PON1 activity and adiponectin were found, versus control normal HDL-c subgroup. However, differences in patients' subgroups were clearly more pronounced. Indeed, low HDL-c subgroup presented increased HbA1c, TGs, non-HDL-c, Ox-LDL, hsCRP, VEGF, and small HDL-c and reduced adiponectin and large HDL. In addition, Ox-LDL, large-HDL-c, and adiponectin presented interesting correlations with classical and nonclassical markers, mainly in the normal HDL-c patients' subgroup. In conclusion, despite LDL-c average levels, low HDL-c concentrations seem to be associated with a poor cardiometabolic profile in a population with cardiovascular risk factors, which is better evidenced by traditional and nontraditional CV biomarkers, including Ox-LDL, large HDL-c, and adiponectin.

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Related in: MedlinePlus

Serum total-HDL-c (a), large HDL-c (b), and small HDL-c (c), in the study groups. Results are presented as mean ± SEM. ***P < 0.001.
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fig1: Serum total-HDL-c (a), large HDL-c (b), and small HDL-c (c), in the study groups. Results are presented as mean ± SEM. ***P < 0.001.

Mentions: Regarding the content of HDL subpopulations, despite the lower levels in both low HDL-c groups (which is obvious by definition of the study groups) (Table 2 and Figure 1(a)), only in the patients population there was a significantly decreased percentage of large HDL-c and increased percentage of small HDL-c, while no differences of HDL subpopulations percentages were found between the two subgroups of controls (normal versus low HDL-c) (Table 2 and Figures 1(b) and 1(c), resp.). Concerning PON1 activity, in the control group, there was a reduced value in the low HDL-c subgroup, while unchanged values were encountered between the two subgroups of patients (Table 2).


Implication of low HDL-c levels in patients with average LDL-c levels: a focus on oxidized LDL, large HDL subpopulation, and adiponectin.

Mascarenhas-Melo F, Sereno J, Teixeira-Lemos E, Marado D, Palavra F, Pinto R, Rocha-Pereira P, Teixeira F, Reis F - Mediators Inflamm. (2013)

Serum total-HDL-c (a), large HDL-c (b), and small HDL-c (c), in the study groups. Results are presented as mean ± SEM. ***P < 0.001.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3824339&req=5

fig1: Serum total-HDL-c (a), large HDL-c (b), and small HDL-c (c), in the study groups. Results are presented as mean ± SEM. ***P < 0.001.
Mentions: Regarding the content of HDL subpopulations, despite the lower levels in both low HDL-c groups (which is obvious by definition of the study groups) (Table 2 and Figure 1(a)), only in the patients population there was a significantly decreased percentage of large HDL-c and increased percentage of small HDL-c, while no differences of HDL subpopulations percentages were found between the two subgroups of controls (normal versus low HDL-c) (Table 2 and Figures 1(b) and 1(c), resp.). Concerning PON1 activity, in the control group, there was a reduced value in the low HDL-c subgroup, while unchanged values were encountered between the two subgroups of patients (Table 2).

Bottom Line: To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles.However, differences in patients' subgroups were clearly more pronounced.In conclusion, despite LDL-c average levels, low HDL-c concentrations seem to be associated with a poor cardiometabolic profile in a population with cardiovascular risk factors, which is better evidenced by traditional and nontraditional CV biomarkers, including Ox-LDL, large HDL-c, and adiponectin.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (Pólo III), University of Coimbra, 3000-548 Coimbra, Portugal.

ABSTRACT
To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles. Patients with cardiovascular risk factors (n = 169) and control subjects (n = 73) were divided into 2 subgroups, one of normal HDL-c and the other of low HDL-c levels. The following data was analyzed: BP, BMI, waist circumference and serum glucose Total-c, TGs, LDL-c, oxidized LDL, total HDL-c and subpopulations (small, intermediate, and large), paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF- α , adiponectin, VEGF, and iCAM1. In the control subgroup with low HDL-c levels, significantly higher values of BP and TGs and lower values of PON1 activity and adiponectin were found, versus control normal HDL-c subgroup. However, differences in patients' subgroups were clearly more pronounced. Indeed, low HDL-c subgroup presented increased HbA1c, TGs, non-HDL-c, Ox-LDL, hsCRP, VEGF, and small HDL-c and reduced adiponectin and large HDL. In addition, Ox-LDL, large-HDL-c, and adiponectin presented interesting correlations with classical and nonclassical markers, mainly in the normal HDL-c patients' subgroup. In conclusion, despite LDL-c average levels, low HDL-c concentrations seem to be associated with a poor cardiometabolic profile in a population with cardiovascular risk factors, which is better evidenced by traditional and nontraditional CV biomarkers, including Ox-LDL, large HDL-c, and adiponectin.

Show MeSH
Related in: MedlinePlus