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The impact of hyperglycemic emergencies on the kidney and liver.

Bai F, Jiang FF, Lu JJ, Ma SG, Peng YG, Jin Y, Xu W, Cheng JP, Wu HF - J Diabetes Res (2013)

Bottom Line: Prealbumin levels were significantly reduced in the severe DKA patients compared with the mild/moderate DKA patients.A diagnostic analysis showed that lower prealbumin levels significantly reflected the presence of hyperglycemic emergencies (P < 0.001).Prealbumin levels can be of value in detecting the presence of hyperglycemic crisis.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Metabolism, Huai'an Hospital Affiliated to Xuzhou Medical College and Huai'an Second People's Hospital, Huai'an 223002, China.

ABSTRACT
Studies on the alterations of liver and kidney function parameters in patients with diabetic ketoacidosis (DKA) and diabetic ketosis (DK) were limited. Participants with DKA, DK, non-DK, and healthy controls were enrolled in the current study. Parameters of liver and kidney function were measured and evaluated. The patients with DKA had higher levels of plasma glucose, hemoglobin A1c (HbA1c), uric acid, and creatinine but lower levels of transferases and protein compared with the other three groups (P < 0.05 for all). The patients with DK had higher levels of plasma glucose and HbA1c but lower levels of glutamyl transpeptidase and protein compared with the non-DK and control groups (P < 0.05). Prealbumin levels were significantly reduced in the severe DKA patients compared with the mild/moderate DKA patients. Serum prealbumin levels were correlated with albumin levels (r = 0.401, P = 0.010), HCO3 (r = 0.350, P = 0.027), and arterial pH (r = 0.597, P < 0.001) in the DKA patients. A diagnostic analysis showed that lower prealbumin levels significantly reflected the presence of hyperglycemic emergencies (P < 0.001). Liver and kidney function parameters deteriorated, especially in DKA. Prealbumin levels can be of value in detecting the presence of hyperglycemic crisis. This clinical trial is registered with ChiCTR-OCH-12003077.

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Related in: MedlinePlus

The ROC plots showed a significant difference in the ability of prealbumin levels to reflect DKA and DK. A comparison of the ROC plots between DKA and DK patients showed a significant difference (P < 0.0001).
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fig2: The ROC plots showed a significant difference in the ability of prealbumin levels to reflect DKA and DK. A comparison of the ROC plots between DKA and DK patients showed a significant difference (P < 0.0001).

Mentions: The ROC curve for the comparison of prealbumin levels in DKA and DK patients is shown in Figure 2. Accordingly, area under the ROC curve (AUC) values were calculated and compared. There were no significant differences in the prealbumin levels of DKA and DK patients. To examine the predictive ability of prealbumin levels in estimating hyperglycemic crises, differences in the AUC values between DKA and DK were calculated, and significant differences were observed (P < 0.0001).


The impact of hyperglycemic emergencies on the kidney and liver.

Bai F, Jiang FF, Lu JJ, Ma SG, Peng YG, Jin Y, Xu W, Cheng JP, Wu HF - J Diabetes Res (2013)

The ROC plots showed a significant difference in the ability of prealbumin levels to reflect DKA and DK. A comparison of the ROC plots between DKA and DK patients showed a significant difference (P < 0.0001).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3824316&req=5

fig2: The ROC plots showed a significant difference in the ability of prealbumin levels to reflect DKA and DK. A comparison of the ROC plots between DKA and DK patients showed a significant difference (P < 0.0001).
Mentions: The ROC curve for the comparison of prealbumin levels in DKA and DK patients is shown in Figure 2. Accordingly, area under the ROC curve (AUC) values were calculated and compared. There were no significant differences in the prealbumin levels of DKA and DK patients. To examine the predictive ability of prealbumin levels in estimating hyperglycemic crises, differences in the AUC values between DKA and DK were calculated, and significant differences were observed (P < 0.0001).

Bottom Line: Prealbumin levels were significantly reduced in the severe DKA patients compared with the mild/moderate DKA patients.A diagnostic analysis showed that lower prealbumin levels significantly reflected the presence of hyperglycemic emergencies (P < 0.001).Prealbumin levels can be of value in detecting the presence of hyperglycemic crisis.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Metabolism, Huai'an Hospital Affiliated to Xuzhou Medical College and Huai'an Second People's Hospital, Huai'an 223002, China.

ABSTRACT
Studies on the alterations of liver and kidney function parameters in patients with diabetic ketoacidosis (DKA) and diabetic ketosis (DK) were limited. Participants with DKA, DK, non-DK, and healthy controls were enrolled in the current study. Parameters of liver and kidney function were measured and evaluated. The patients with DKA had higher levels of plasma glucose, hemoglobin A1c (HbA1c), uric acid, and creatinine but lower levels of transferases and protein compared with the other three groups (P < 0.05 for all). The patients with DK had higher levels of plasma glucose and HbA1c but lower levels of glutamyl transpeptidase and protein compared with the non-DK and control groups (P < 0.05). Prealbumin levels were significantly reduced in the severe DKA patients compared with the mild/moderate DKA patients. Serum prealbumin levels were correlated with albumin levels (r = 0.401, P = 0.010), HCO3 (r = 0.350, P = 0.027), and arterial pH (r = 0.597, P < 0.001) in the DKA patients. A diagnostic analysis showed that lower prealbumin levels significantly reflected the presence of hyperglycemic emergencies (P < 0.001). Liver and kidney function parameters deteriorated, especially in DKA. Prealbumin levels can be of value in detecting the presence of hyperglycemic crisis. This clinical trial is registered with ChiCTR-OCH-12003077.

Show MeSH
Related in: MedlinePlus