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Arteriovenous passage times and visual field progression in normal tension glaucoma.

Koch EC, Arend KO, Bienert M, Remky A, Plange N - ScientificWorldJournal (2013)

Bottom Line: Patients with a follow-up period of at least 3 years and at least 4 visual field examinations were included in this retrospective study.Fluorescein angiography was performed at baseline using a confocal scanning laser ophthalmoscope (SLO, Rodenstock Instr.); fluorescein filling defects and AVP were measured by digital image analysis and dye dilution curves (25 Hz).Impaired retinal blood flow seems to be an important factor for glaucoma progression.

View Article: PubMed Central - PubMed

Affiliation: Deptartment of Ophthalmology, RWTH Aachen University, Pauwelsstraße 30, 52057 Aachen, Germany.

ABSTRACT

Purpose: Fluorescein angiographic studies revealed prolonged arteriovenous passage (AVP) times and increased fluorescein filling defects in normal tension glaucoma (NTG) compared to healthy controls. The purpose of this study was to correlate baseline AVP and fluorescein filling defects with visual field progression in patients with NTG.

Patients and methods: Patients with a follow-up period of at least 3 years and at least 4 visual field examinations were included in this retrospective study. Fluorescein angiography was performed at baseline using a confocal scanning laser ophthalmoscope (SLO, Rodenstock Instr.); fluorescein filling defects and AVP were measured by digital image analysis and dye dilution curves (25 Hz). Visual field progression was evaluated using regression analysis of the MD (Humphrey-Zeiss, SITA-24-2, MD progression per year (dB/year)). 72 patients with NTG were included, 44 patients in study 1 (fluorescein filling defects) and 28 patients in study 2 (AVP).

Results: In study 1 (mean follow-up 6.6 ± 1.9 years, 10 ± 5 visual field tests), MD progression per year (-0.51 ± 0.59 dB/year) was significantly correlated to the age (P = 0.04, r = -0.29) but not to fluorescein filling defects, IOP, or MD at baseline. In study 2 (mean follow-up 6.6 ± 2.2 years, 10 ± 5 visual field tests), MD progression per year (-0.45 ± 0.51 dB/year) was significantly correlated to AVP (P = 0.03, r = 0.39) but not to age, IOP, or MD at baseline.

Conclusion: Longer AVP times at baseline are correlated to visual field progression in NTG. Impaired retinal blood flow seems to be an important factor for glaucoma progression.

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Related in: MedlinePlus

Bivariate plot of AVP (P = 0.03, r = −0.39) as a function of MD progression per year in patients with NTG.
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fig2: Bivariate plot of AVP (P = 0.03, r = −0.39) as a function of MD progression per year in patients with NTG.

Mentions: In study 2 (AVP), mean follow-up period was 6.6 ± 2.2 years (range 3.2–11) and each patient underwent on average 10 ± 5 visual field tests (range 4–21). MD progression per year was significantly correlated to AVP time (P = 0.03, r = −0.39, Figure 2). But no significant correlation was found between MD Progression per year and age, MD at baseline, and baseline IOP.


Arteriovenous passage times and visual field progression in normal tension glaucoma.

Koch EC, Arend KO, Bienert M, Remky A, Plange N - ScientificWorldJournal (2013)

Bivariate plot of AVP (P = 0.03, r = −0.39) as a function of MD progression per year in patients with NTG.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3824313&req=5

fig2: Bivariate plot of AVP (P = 0.03, r = −0.39) as a function of MD progression per year in patients with NTG.
Mentions: In study 2 (AVP), mean follow-up period was 6.6 ± 2.2 years (range 3.2–11) and each patient underwent on average 10 ± 5 visual field tests (range 4–21). MD progression per year was significantly correlated to AVP time (P = 0.03, r = −0.39, Figure 2). But no significant correlation was found between MD Progression per year and age, MD at baseline, and baseline IOP.

Bottom Line: Patients with a follow-up period of at least 3 years and at least 4 visual field examinations were included in this retrospective study.Fluorescein angiography was performed at baseline using a confocal scanning laser ophthalmoscope (SLO, Rodenstock Instr.); fluorescein filling defects and AVP were measured by digital image analysis and dye dilution curves (25 Hz).Impaired retinal blood flow seems to be an important factor for glaucoma progression.

View Article: PubMed Central - PubMed

Affiliation: Deptartment of Ophthalmology, RWTH Aachen University, Pauwelsstraße 30, 52057 Aachen, Germany.

ABSTRACT

Purpose: Fluorescein angiographic studies revealed prolonged arteriovenous passage (AVP) times and increased fluorescein filling defects in normal tension glaucoma (NTG) compared to healthy controls. The purpose of this study was to correlate baseline AVP and fluorescein filling defects with visual field progression in patients with NTG.

Patients and methods: Patients with a follow-up period of at least 3 years and at least 4 visual field examinations were included in this retrospective study. Fluorescein angiography was performed at baseline using a confocal scanning laser ophthalmoscope (SLO, Rodenstock Instr.); fluorescein filling defects and AVP were measured by digital image analysis and dye dilution curves (25 Hz). Visual field progression was evaluated using regression analysis of the MD (Humphrey-Zeiss, SITA-24-2, MD progression per year (dB/year)). 72 patients with NTG were included, 44 patients in study 1 (fluorescein filling defects) and 28 patients in study 2 (AVP).

Results: In study 1 (mean follow-up 6.6 ± 1.9 years, 10 ± 5 visual field tests), MD progression per year (-0.51 ± 0.59 dB/year) was significantly correlated to the age (P = 0.04, r = -0.29) but not to fluorescein filling defects, IOP, or MD at baseline. In study 2 (mean follow-up 6.6 ± 2.2 years, 10 ± 5 visual field tests), MD progression per year (-0.45 ± 0.51 dB/year) was significantly correlated to AVP (P = 0.03, r = 0.39) but not to age, IOP, or MD at baseline.

Conclusion: Longer AVP times at baseline are correlated to visual field progression in NTG. Impaired retinal blood flow seems to be an important factor for glaucoma progression.

Show MeSH
Related in: MedlinePlus