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Effects of preoperative exposure to a high-fat versus a low-fat diet on ingestive behavior after gastric bypass surgery in rats.

Seyfried F, Miras AD, Bueter M, Prechtl CG, Spector AC, le Roux CW - Surg Endosc (2013)

Bottom Line: In food preference test 1, both groups responded similarly by reducing their preference for Ensure and increasing their preference for V8.In food preference test 2, the HFDF-GB rats reduced their preference for a solid high-fat diet gradually compared with the immediate reduction observed in the LFDF-GB rats.These results suggest that for some physiologic parameters, low-fat-induced obesity models can be used for the study of changes after GB and have relevance to many obese humans who consume high-calorie but low-fat diets.

View Article: PubMed Central - PubMed

Affiliation: Investigative Science, Imperial College London, Du Cane Road, London, W12 0NN, UK.

ABSTRACT

Background: The consumption of high fat and sugar diets is decreased after gastric bypass surgery (GB). The mechanisms remain unclear, with tests of motivated behavior toward fat and sugar producing conflicting results in a rat model. These discrepancies may be due to differences in presurgical maintenance diets. The authors used their GB rat model to determine whether the fat content of preoperative maintenance diets affects weight loss, calorie intake, and macronutrient selection after surgery.

Methods: Male Wistar rats were either low-fat diet fed (LFDF) with normal chow or high-fat diet fed (HFDF) before randomization to GB or sham surgery. In food preference test 1, the animals were offered the choice of a vegetable drink (V8) or a high-calorie liquid (Ensure), and in food preference test 2, they could choose normal chow or a solid high-fat diet.

Results: The GB groups did not differ significantly in terms of body weight loss or caloric intake. In food preference test 1, both groups responded similarly by reducing their preference for Ensure and increasing their preference for V8. In food preference test 2, the HFDF-GB rats reduced their preference for a solid high-fat diet gradually compared with the immediate reduction observed in the LFDF-GB rats.

Conclusion: The consumption of presurgical maintenance diets with different fat contents did not affect postoperative weight loss outcomes. Both the LFDF-GB and HFDF-GB rats exhibited behaviors consistent with the possible expression of a conditioned taste aversion to a high-fat stimulus. These results suggest that for some physiologic parameters, low-fat-induced obesity models can be used for the study of changes after GB and have relevance to many obese humans who consume high-calorie but low-fat diets.

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Related in: MedlinePlus

Food intake of a solid high-fat diet in green and normal chow in brown for the A HFDF-SH (n = 5, filled circles), B HFDF-GB (n = 5, empty circles), C LFDF-SH (n = 6, filled squares), D LFDF-GB (n = 8, empty squares) groups during food preference test 2 (FPT 2), which took place between postoperative days 26 and 29. Data are presented as mean ± standard error of the mean (SEM). HFDF high-fat diet fed, LFDF low-fat diet fed, SH sham procedure, GB gastric bypass (Color figure online)
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Fig6: Food intake of a solid high-fat diet in green and normal chow in brown for the A HFDF-SH (n = 5, filled circles), B HFDF-GB (n = 5, empty circles), C LFDF-SH (n = 6, filled squares), D LFDF-GB (n = 8, empty squares) groups during food preference test 2 (FPT 2), which took place between postoperative days 26 and 29. Data are presented as mean ± standard error of the mean (SEM). HFDF high-fat diet fed, LFDF low-fat diet fed, SH sham procedure, GB gastric bypass (Color figure online)

Mentions: Figure 6 demonstrates the food intake of all four groups during food preference test 2, which took place on postoperative days 26–29. Table 1B summarizes the results of food preference test 2. Within both the HFDF and LFDF groups, surgery had a significant effect, with the GB rats showing a significantly lower intake of solid high-fat diet than the SH animals. Within the GB group, preoperative dietary exposure had a significant effect, with the rats exposed to LFDF preoperatively consuming significantly less solid high-fat diet than the rats exposed to HFDF preoperatively. Preoperative dietary exposure did not have an effect on solid high-fat intake in the SH group.Fig. 6


Effects of preoperative exposure to a high-fat versus a low-fat diet on ingestive behavior after gastric bypass surgery in rats.

Seyfried F, Miras AD, Bueter M, Prechtl CG, Spector AC, le Roux CW - Surg Endosc (2013)

Food intake of a solid high-fat diet in green and normal chow in brown for the A HFDF-SH (n = 5, filled circles), B HFDF-GB (n = 5, empty circles), C LFDF-SH (n = 6, filled squares), D LFDF-GB (n = 8, empty squares) groups during food preference test 2 (FPT 2), which took place between postoperative days 26 and 29. Data are presented as mean ± standard error of the mean (SEM). HFDF high-fat diet fed, LFDF low-fat diet fed, SH sham procedure, GB gastric bypass (Color figure online)
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Related In: Results  -  Collection

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Fig6: Food intake of a solid high-fat diet in green and normal chow in brown for the A HFDF-SH (n = 5, filled circles), B HFDF-GB (n = 5, empty circles), C LFDF-SH (n = 6, filled squares), D LFDF-GB (n = 8, empty squares) groups during food preference test 2 (FPT 2), which took place between postoperative days 26 and 29. Data are presented as mean ± standard error of the mean (SEM). HFDF high-fat diet fed, LFDF low-fat diet fed, SH sham procedure, GB gastric bypass (Color figure online)
Mentions: Figure 6 demonstrates the food intake of all four groups during food preference test 2, which took place on postoperative days 26–29. Table 1B summarizes the results of food preference test 2. Within both the HFDF and LFDF groups, surgery had a significant effect, with the GB rats showing a significantly lower intake of solid high-fat diet than the SH animals. Within the GB group, preoperative dietary exposure had a significant effect, with the rats exposed to LFDF preoperatively consuming significantly less solid high-fat diet than the rats exposed to HFDF preoperatively. Preoperative dietary exposure did not have an effect on solid high-fat intake in the SH group.Fig. 6

Bottom Line: In food preference test 1, both groups responded similarly by reducing their preference for Ensure and increasing their preference for V8.In food preference test 2, the HFDF-GB rats reduced their preference for a solid high-fat diet gradually compared with the immediate reduction observed in the LFDF-GB rats.These results suggest that for some physiologic parameters, low-fat-induced obesity models can be used for the study of changes after GB and have relevance to many obese humans who consume high-calorie but low-fat diets.

View Article: PubMed Central - PubMed

Affiliation: Investigative Science, Imperial College London, Du Cane Road, London, W12 0NN, UK.

ABSTRACT

Background: The consumption of high fat and sugar diets is decreased after gastric bypass surgery (GB). The mechanisms remain unclear, with tests of motivated behavior toward fat and sugar producing conflicting results in a rat model. These discrepancies may be due to differences in presurgical maintenance diets. The authors used their GB rat model to determine whether the fat content of preoperative maintenance diets affects weight loss, calorie intake, and macronutrient selection after surgery.

Methods: Male Wistar rats were either low-fat diet fed (LFDF) with normal chow or high-fat diet fed (HFDF) before randomization to GB or sham surgery. In food preference test 1, the animals were offered the choice of a vegetable drink (V8) or a high-calorie liquid (Ensure), and in food preference test 2, they could choose normal chow or a solid high-fat diet.

Results: The GB groups did not differ significantly in terms of body weight loss or caloric intake. In food preference test 1, both groups responded similarly by reducing their preference for Ensure and increasing their preference for V8. In food preference test 2, the HFDF-GB rats reduced their preference for a solid high-fat diet gradually compared with the immediate reduction observed in the LFDF-GB rats.

Conclusion: The consumption of presurgical maintenance diets with different fat contents did not affect postoperative weight loss outcomes. Both the LFDF-GB and HFDF-GB rats exhibited behaviors consistent with the possible expression of a conditioned taste aversion to a high-fat stimulus. These results suggest that for some physiologic parameters, low-fat-induced obesity models can be used for the study of changes after GB and have relevance to many obese humans who consume high-calorie but low-fat diets.

Show MeSH
Related in: MedlinePlus