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The role of myeloperoxidase and myeloperoxidase-antineutrophil cytoplasmic antibodies (MPO-ANCAs) in the pathogenesis of human MPO-ANCA-associated glomerulonephritis.

Arimura Y, Kawashima S, Yoshihara K, Komagata Y, Kaname S, Yamada A - Clin. Exp. Nephrol. (2013)

Bottom Line: It is well known that antineutrophil cytoplasmic antibodies (ANCAs) are pathogenic and have a diagnostic value for ANCA-associated vasculitis.We demonstrated that a rise in myeloperoxidase (MPO)-ANCA titers during remission is often predictive of a future relapse in MPO-ANCA-associated vasculitis.Pathological examination of renal biopsies indicated that not only MPO-ANCAs, but also extracellular MPO, an in situ immune complex composed of MPO and MPO antibodies, may play important roles in the pathogenesis of glomerular capillary injury in MPO-ANCA-associated vasculitis.

View Article: PubMed Central - PubMed

Affiliation: First Department of Internal Medicine (Nephrology and Rheumatology), Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan, arimuray@ks.jkyorin-u.ac.jp.

ABSTRACT
It is well known that antineutrophil cytoplasmic antibodies (ANCAs) are pathogenic and have a diagnostic value for ANCA-associated vasculitis. We demonstrated that a rise in myeloperoxidase (MPO)-ANCA titers during remission is often predictive of a future relapse in MPO-ANCA-associated vasculitis. Pathological examination of renal biopsies indicated that not only MPO-ANCAs, but also extracellular MPO, an in situ immune complex composed of MPO and MPO antibodies, may play important roles in the pathogenesis of glomerular capillary injury in MPO-ANCA-associated vasculitis.

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Double staining of MPO and CD34 by immunofluorescence microscopy. ①②③: Green shows MPO-positive staining. MPO is stained along the glomerular capillary wall without CD34 staining. ④⑤: Red shows CD34-positive staining. CD34 is stained along the glomerular capillary wall without MPO staining. ⑥: Yellow shows double-positive staining of MPO and CD34. Blue shows nuclear cell
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Fig3: Double staining of MPO and CD34 by immunofluorescence microscopy. ①②③: Green shows MPO-positive staining. MPO is stained along the glomerular capillary wall without CD34 staining. ④⑤: Red shows CD34-positive staining. CD34 is stained along the glomerular capillary wall without MPO staining. ⑥: Yellow shows double-positive staining of MPO and CD34. Blue shows nuclear cell

Mentions: MPO was detected along the glomerular capillary wall near MPO-positive cells which was accompanied by decreased staining of CD34 in some areas of the glomerulus suggesting capillary injuries (Fig. 3). In other areas, double staining of MPO and CD34 was seen [5, 6].Fig. 3


The role of myeloperoxidase and myeloperoxidase-antineutrophil cytoplasmic antibodies (MPO-ANCAs) in the pathogenesis of human MPO-ANCA-associated glomerulonephritis.

Arimura Y, Kawashima S, Yoshihara K, Komagata Y, Kaname S, Yamada A - Clin. Exp. Nephrol. (2013)

Double staining of MPO and CD34 by immunofluorescence microscopy. ①②③: Green shows MPO-positive staining. MPO is stained along the glomerular capillary wall without CD34 staining. ④⑤: Red shows CD34-positive staining. CD34 is stained along the glomerular capillary wall without MPO staining. ⑥: Yellow shows double-positive staining of MPO and CD34. Blue shows nuclear cell
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3824275&req=5

Fig3: Double staining of MPO and CD34 by immunofluorescence microscopy. ①②③: Green shows MPO-positive staining. MPO is stained along the glomerular capillary wall without CD34 staining. ④⑤: Red shows CD34-positive staining. CD34 is stained along the glomerular capillary wall without MPO staining. ⑥: Yellow shows double-positive staining of MPO and CD34. Blue shows nuclear cell
Mentions: MPO was detected along the glomerular capillary wall near MPO-positive cells which was accompanied by decreased staining of CD34 in some areas of the glomerulus suggesting capillary injuries (Fig. 3). In other areas, double staining of MPO and CD34 was seen [5, 6].Fig. 3

Bottom Line: It is well known that antineutrophil cytoplasmic antibodies (ANCAs) are pathogenic and have a diagnostic value for ANCA-associated vasculitis.We demonstrated that a rise in myeloperoxidase (MPO)-ANCA titers during remission is often predictive of a future relapse in MPO-ANCA-associated vasculitis.Pathological examination of renal biopsies indicated that not only MPO-ANCAs, but also extracellular MPO, an in situ immune complex composed of MPO and MPO antibodies, may play important roles in the pathogenesis of glomerular capillary injury in MPO-ANCA-associated vasculitis.

View Article: PubMed Central - PubMed

Affiliation: First Department of Internal Medicine (Nephrology and Rheumatology), Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan, arimuray@ks.jkyorin-u.ac.jp.

ABSTRACT
It is well known that antineutrophil cytoplasmic antibodies (ANCAs) are pathogenic and have a diagnostic value for ANCA-associated vasculitis. We demonstrated that a rise in myeloperoxidase (MPO)-ANCA titers during remission is often predictive of a future relapse in MPO-ANCA-associated vasculitis. Pathological examination of renal biopsies indicated that not only MPO-ANCAs, but also extracellular MPO, an in situ immune complex composed of MPO and MPO antibodies, may play important roles in the pathogenesis of glomerular capillary injury in MPO-ANCA-associated vasculitis.

Show MeSH
Related in: MedlinePlus