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The role of myeloperoxidase and myeloperoxidase-antineutrophil cytoplasmic antibodies (MPO-ANCAs) in the pathogenesis of human MPO-ANCA-associated glomerulonephritis.

Arimura Y, Kawashima S, Yoshihara K, Komagata Y, Kaname S, Yamada A - Clin. Exp. Nephrol. (2013)

Bottom Line: It is well known that antineutrophil cytoplasmic antibodies (ANCAs) are pathogenic and have a diagnostic value for ANCA-associated vasculitis.We demonstrated that a rise in myeloperoxidase (MPO)-ANCA titers during remission is often predictive of a future relapse in MPO-ANCA-associated vasculitis.Pathological examination of renal biopsies indicated that not only MPO-ANCAs, but also extracellular MPO, an in situ immune complex composed of MPO and MPO antibodies, may play important roles in the pathogenesis of glomerular capillary injury in MPO-ANCA-associated vasculitis.

View Article: PubMed Central - PubMed

Affiliation: First Department of Internal Medicine (Nephrology and Rheumatology), Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan, arimuray@ks.jkyorin-u.ac.jp.

ABSTRACT
It is well known that antineutrophil cytoplasmic antibodies (ANCAs) are pathogenic and have a diagnostic value for ANCA-associated vasculitis. We demonstrated that a rise in myeloperoxidase (MPO)-ANCA titers during remission is often predictive of a future relapse in MPO-ANCA-associated vasculitis. Pathological examination of renal biopsies indicated that not only MPO-ANCAs, but also extracellular MPO, an in situ immune complex composed of MPO and MPO antibodies, may play important roles in the pathogenesis of glomerular capillary injury in MPO-ANCA-associated vasculitis.

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Comparison of MPO and CD34 staining on the serial sections in early segmental change glomerulus. a–c MPO staining: MPO (red), nucleus (blue). MPO-positive cells (long arrows) are observed in the glomerular capillary lumen. MPO is stained along the glomerular capillary walls (short arrows) near the MPO-positive cells. c, d CD34 staining: CD34 (red), nucleus (blue). CD34 staining decreased (arrows) on the glomerular capillary wall. Red blood cells (asterisk) are observed in the Bowman’s space, which suggesting the rupture of the glomerular capillary wall
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Fig2: Comparison of MPO and CD34 staining on the serial sections in early segmental change glomerulus. a–c MPO staining: MPO (red), nucleus (blue). MPO-positive cells (long arrows) are observed in the glomerular capillary lumen. MPO is stained along the glomerular capillary walls (short arrows) near the MPO-positive cells. c, d CD34 staining: CD34 (red), nucleus (blue). CD34 staining decreased (arrows) on the glomerular capillary wall. Red blood cells (asterisk) are observed in the Bowman’s space, which suggesting the rupture of the glomerular capillary wall

Mentions: MPO existed along the glomerular capillary walls near the infiltrated MPO-positive cells in active (Fig. 1a–c) and early-phase necrotizing GN (NGN) (Fig. 2a, b). CD34 staining was decreased on the adjacent area of the same glomerulus (Fig. 2c, d). Many MPO-positive cells and MPO along the glomerular capillary wall were detected in active and more severely damaged NGN (data not shown) [5]. MPO-positive cells and MPO were not detected on the glomerular capillaries during inactive and chronic-phase NGN [5].Fig. 1


The role of myeloperoxidase and myeloperoxidase-antineutrophil cytoplasmic antibodies (MPO-ANCAs) in the pathogenesis of human MPO-ANCA-associated glomerulonephritis.

Arimura Y, Kawashima S, Yoshihara K, Komagata Y, Kaname S, Yamada A - Clin. Exp. Nephrol. (2013)

Comparison of MPO and CD34 staining on the serial sections in early segmental change glomerulus. a–c MPO staining: MPO (red), nucleus (blue). MPO-positive cells (long arrows) are observed in the glomerular capillary lumen. MPO is stained along the glomerular capillary walls (short arrows) near the MPO-positive cells. c, d CD34 staining: CD34 (red), nucleus (blue). CD34 staining decreased (arrows) on the glomerular capillary wall. Red blood cells (asterisk) are observed in the Bowman’s space, which suggesting the rupture of the glomerular capillary wall
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3824275&req=5

Fig2: Comparison of MPO and CD34 staining on the serial sections in early segmental change glomerulus. a–c MPO staining: MPO (red), nucleus (blue). MPO-positive cells (long arrows) are observed in the glomerular capillary lumen. MPO is stained along the glomerular capillary walls (short arrows) near the MPO-positive cells. c, d CD34 staining: CD34 (red), nucleus (blue). CD34 staining decreased (arrows) on the glomerular capillary wall. Red blood cells (asterisk) are observed in the Bowman’s space, which suggesting the rupture of the glomerular capillary wall
Mentions: MPO existed along the glomerular capillary walls near the infiltrated MPO-positive cells in active (Fig. 1a–c) and early-phase necrotizing GN (NGN) (Fig. 2a, b). CD34 staining was decreased on the adjacent area of the same glomerulus (Fig. 2c, d). Many MPO-positive cells and MPO along the glomerular capillary wall were detected in active and more severely damaged NGN (data not shown) [5]. MPO-positive cells and MPO were not detected on the glomerular capillaries during inactive and chronic-phase NGN [5].Fig. 1

Bottom Line: It is well known that antineutrophil cytoplasmic antibodies (ANCAs) are pathogenic and have a diagnostic value for ANCA-associated vasculitis.We demonstrated that a rise in myeloperoxidase (MPO)-ANCA titers during remission is often predictive of a future relapse in MPO-ANCA-associated vasculitis.Pathological examination of renal biopsies indicated that not only MPO-ANCAs, but also extracellular MPO, an in situ immune complex composed of MPO and MPO antibodies, may play important roles in the pathogenesis of glomerular capillary injury in MPO-ANCA-associated vasculitis.

View Article: PubMed Central - PubMed

Affiliation: First Department of Internal Medicine (Nephrology and Rheumatology), Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan, arimuray@ks.jkyorin-u.ac.jp.

ABSTRACT
It is well known that antineutrophil cytoplasmic antibodies (ANCAs) are pathogenic and have a diagnostic value for ANCA-associated vasculitis. We demonstrated that a rise in myeloperoxidase (MPO)-ANCA titers during remission is often predictive of a future relapse in MPO-ANCA-associated vasculitis. Pathological examination of renal biopsies indicated that not only MPO-ANCAs, but also extracellular MPO, an in situ immune complex composed of MPO and MPO antibodies, may play important roles in the pathogenesis of glomerular capillary injury in MPO-ANCA-associated vasculitis.

Show MeSH
Related in: MedlinePlus