Limits...
The role of myeloperoxidase and myeloperoxidase-antineutrophil cytoplasmic antibodies (MPO-ANCAs) in the pathogenesis of human MPO-ANCA-associated glomerulonephritis.

Arimura Y, Kawashima S, Yoshihara K, Komagata Y, Kaname S, Yamada A - Clin. Exp. Nephrol. (2013)

Bottom Line: It is well known that antineutrophil cytoplasmic antibodies (ANCAs) are pathogenic and have a diagnostic value for ANCA-associated vasculitis.We demonstrated that a rise in myeloperoxidase (MPO)-ANCA titers during remission is often predictive of a future relapse in MPO-ANCA-associated vasculitis.Pathological examination of renal biopsies indicated that not only MPO-ANCAs, but also extracellular MPO, an in situ immune complex composed of MPO and MPO antibodies, may play important roles in the pathogenesis of glomerular capillary injury in MPO-ANCA-associated vasculitis.

View Article: PubMed Central - PubMed

Affiliation: First Department of Internal Medicine (Nephrology and Rheumatology), Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan, arimuray@ks.jkyorin-u.ac.jp.

ABSTRACT
It is well known that antineutrophil cytoplasmic antibodies (ANCAs) are pathogenic and have a diagnostic value for ANCA-associated vasculitis. We demonstrated that a rise in myeloperoxidase (MPO)-ANCA titers during remission is often predictive of a future relapse in MPO-ANCA-associated vasculitis. Pathological examination of renal biopsies indicated that not only MPO-ANCAs, but also extracellular MPO, an in situ immune complex composed of MPO and MPO antibodies, may play important roles in the pathogenesis of glomerular capillary injury in MPO-ANCA-associated vasculitis.

Show MeSH

Related in: MedlinePlus

MPO staining in the glomeruli of patients with MPO-ANCA-associated glomerulonephritis. a MPO-positive cells and MPO are shown in the glomerulus and along the glomerular capillary wall, respectively. b MPO in the cytoplasm of a polymorphonuclear leukocyte (arrow) (MPO staining). c MPO along the glomerular capillary wall (arrow) (MPO staining). d Periodic acid silver methenamine and hematoxylin and eoxin staining on the serial sections in active segmental necrotizing glomerular changes
© Copyright Policy - OpenAccess
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3824275&req=5

Fig1: MPO staining in the glomeruli of patients with MPO-ANCA-associated glomerulonephritis. a MPO-positive cells and MPO are shown in the glomerulus and along the glomerular capillary wall, respectively. b MPO in the cytoplasm of a polymorphonuclear leukocyte (arrow) (MPO staining). c MPO along the glomerular capillary wall (arrow) (MPO staining). d Periodic acid silver methenamine and hematoxylin and eoxin staining on the serial sections in active segmental necrotizing glomerular changes

Mentions: MPO existed along the glomerular capillary walls near the infiltrated MPO-positive cells in active (Fig. 1a–c) and early-phase necrotizing GN (NGN) (Fig. 2a, b). CD34 staining was decreased on the adjacent area of the same glomerulus (Fig. 2c, d). Many MPO-positive cells and MPO along the glomerular capillary wall were detected in active and more severely damaged NGN (data not shown) [5]. MPO-positive cells and MPO were not detected on the glomerular capillaries during inactive and chronic-phase NGN [5].Fig. 1


The role of myeloperoxidase and myeloperoxidase-antineutrophil cytoplasmic antibodies (MPO-ANCAs) in the pathogenesis of human MPO-ANCA-associated glomerulonephritis.

Arimura Y, Kawashima S, Yoshihara K, Komagata Y, Kaname S, Yamada A - Clin. Exp. Nephrol. (2013)

MPO staining in the glomeruli of patients with MPO-ANCA-associated glomerulonephritis. a MPO-positive cells and MPO are shown in the glomerulus and along the glomerular capillary wall, respectively. b MPO in the cytoplasm of a polymorphonuclear leukocyte (arrow) (MPO staining). c MPO along the glomerular capillary wall (arrow) (MPO staining). d Periodic acid silver methenamine and hematoxylin and eoxin staining on the serial sections in active segmental necrotizing glomerular changes
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3824275&req=5

Fig1: MPO staining in the glomeruli of patients with MPO-ANCA-associated glomerulonephritis. a MPO-positive cells and MPO are shown in the glomerulus and along the glomerular capillary wall, respectively. b MPO in the cytoplasm of a polymorphonuclear leukocyte (arrow) (MPO staining). c MPO along the glomerular capillary wall (arrow) (MPO staining). d Periodic acid silver methenamine and hematoxylin and eoxin staining on the serial sections in active segmental necrotizing glomerular changes
Mentions: MPO existed along the glomerular capillary walls near the infiltrated MPO-positive cells in active (Fig. 1a–c) and early-phase necrotizing GN (NGN) (Fig. 2a, b). CD34 staining was decreased on the adjacent area of the same glomerulus (Fig. 2c, d). Many MPO-positive cells and MPO along the glomerular capillary wall were detected in active and more severely damaged NGN (data not shown) [5]. MPO-positive cells and MPO were not detected on the glomerular capillaries during inactive and chronic-phase NGN [5].Fig. 1

Bottom Line: It is well known that antineutrophil cytoplasmic antibodies (ANCAs) are pathogenic and have a diagnostic value for ANCA-associated vasculitis.We demonstrated that a rise in myeloperoxidase (MPO)-ANCA titers during remission is often predictive of a future relapse in MPO-ANCA-associated vasculitis.Pathological examination of renal biopsies indicated that not only MPO-ANCAs, but also extracellular MPO, an in situ immune complex composed of MPO and MPO antibodies, may play important roles in the pathogenesis of glomerular capillary injury in MPO-ANCA-associated vasculitis.

View Article: PubMed Central - PubMed

Affiliation: First Department of Internal Medicine (Nephrology and Rheumatology), Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan, arimuray@ks.jkyorin-u.ac.jp.

ABSTRACT
It is well known that antineutrophil cytoplasmic antibodies (ANCAs) are pathogenic and have a diagnostic value for ANCA-associated vasculitis. We demonstrated that a rise in myeloperoxidase (MPO)-ANCA titers during remission is often predictive of a future relapse in MPO-ANCA-associated vasculitis. Pathological examination of renal biopsies indicated that not only MPO-ANCAs, but also extracellular MPO, an in situ immune complex composed of MPO and MPO antibodies, may play important roles in the pathogenesis of glomerular capillary injury in MPO-ANCA-associated vasculitis.

Show MeSH
Related in: MedlinePlus