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Evaluation of the newly proposed simplified histological classification in Japanese cohorts of myeloperoxidase-anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in comparison with other Asian and European cohorts.

Muso E, Endo T, Itabashi M, Kakita H, Iwasaki Y, Tateishi Y, Komiya T, Ihara T, Yumura W, Sugiyama T, Joh K, Suzuki K - Clin. Exp. Nephrol. (2012)

Bottom Line: Berden et al. proposed a new classification of glomerulonephritis in ANCA-associated vasculitis (AAV) categorized into focal, crescentic, mixed, and sclerotic classes and showed its prognostic value in 100 international multicenter cohorts for 1- and 5-year renal outcomes.In order to evaluate whether this new classification has predictive value and reproducibility in Japanese AAV cases, 87 cohorts with only microscopic polyangiitis in 3 limited centers in Japan were analyzed.In addition, those from Japan, Europe (Berden's cohorts) and China were compared in a recent report.

View Article: PubMed Central - PubMed

Affiliation: Division of Nephrology and Dialysis, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan, muso@kitano-hp.or.jp.

ABSTRACT
The prognostic value of renal biopsy in anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis is widely recognized; however, there is no consensus regarding its pathological classification. Berden et al. proposed a new classification of glomerulonephritis in ANCA-associated vasculitis (AAV) categorized into focal, crescentic, mixed, and sclerotic classes and showed its prognostic value in 100 international multicenter cohorts for 1- and 5-year renal outcomes. In order to evaluate whether this new classification has predictive value and reproducibility in Japanese AAV cases, 87 cohorts with only microscopic polyangiitis in 3 limited centers in Japan were analyzed. In addition, those from Japan, Europe (Berden's cohorts) and China were compared in a recent report.

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Renal survival (no development of end-stage renal failure) according to the four histologic categories in Japanese cohorts
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Fig1: Renal survival (no development of end-stage renal failure) according to the four histologic categories in Japanese cohorts

Mentions: In Japanese patients, almost half of the cases were categorized as focal (40/87; 46.0 %) with 14/87 (16.1 %) as sclerotic. Of the other 32 cases, only 7 (8.0 %) were categorized as crescentic, with the remaining 26 cases (29.9 %) being classed as mixed. As shown in Fig. 1, the Kaplan−Meier curve at the 5-year follow-up showed no increase of probability to ESRD in focal cases and a low increase in mixed cases; however, this increased with the ascending categories of crescentic and sclerotic GN.Fig. 1


Evaluation of the newly proposed simplified histological classification in Japanese cohorts of myeloperoxidase-anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in comparison with other Asian and European cohorts.

Muso E, Endo T, Itabashi M, Kakita H, Iwasaki Y, Tateishi Y, Komiya T, Ihara T, Yumura W, Sugiyama T, Joh K, Suzuki K - Clin. Exp. Nephrol. (2012)

Renal survival (no development of end-stage renal failure) according to the four histologic categories in Japanese cohorts
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3824231&req=5

Fig1: Renal survival (no development of end-stage renal failure) according to the four histologic categories in Japanese cohorts
Mentions: In Japanese patients, almost half of the cases were categorized as focal (40/87; 46.0 %) with 14/87 (16.1 %) as sclerotic. Of the other 32 cases, only 7 (8.0 %) were categorized as crescentic, with the remaining 26 cases (29.9 %) being classed as mixed. As shown in Fig. 1, the Kaplan−Meier curve at the 5-year follow-up showed no increase of probability to ESRD in focal cases and a low increase in mixed cases; however, this increased with the ascending categories of crescentic and sclerotic GN.Fig. 1

Bottom Line: Berden et al. proposed a new classification of glomerulonephritis in ANCA-associated vasculitis (AAV) categorized into focal, crescentic, mixed, and sclerotic classes and showed its prognostic value in 100 international multicenter cohorts for 1- and 5-year renal outcomes.In order to evaluate whether this new classification has predictive value and reproducibility in Japanese AAV cases, 87 cohorts with only microscopic polyangiitis in 3 limited centers in Japan were analyzed.In addition, those from Japan, Europe (Berden's cohorts) and China were compared in a recent report.

View Article: PubMed Central - PubMed

Affiliation: Division of Nephrology and Dialysis, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan, muso@kitano-hp.or.jp.

ABSTRACT
The prognostic value of renal biopsy in anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis is widely recognized; however, there is no consensus regarding its pathological classification. Berden et al. proposed a new classification of glomerulonephritis in ANCA-associated vasculitis (AAV) categorized into focal, crescentic, mixed, and sclerotic classes and showed its prognostic value in 100 international multicenter cohorts for 1- and 5-year renal outcomes. In order to evaluate whether this new classification has predictive value and reproducibility in Japanese AAV cases, 87 cohorts with only microscopic polyangiitis in 3 limited centers in Japan were analyzed. In addition, those from Japan, Europe (Berden's cohorts) and China were compared in a recent report.

Show MeSH
Related in: MedlinePlus