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Geraniol ameliorates the motor behavior and neurotrophic factors inadequacy in MPTP-induced mice model of Parkinson's disease.

Rekha KR, Selvakumar GP, Sethupathy S, Santha K, Sivakamasundari RI - J. Mol. Neurosci. (2013)

Bottom Line: Many experiments affirm the notion that augmentation of neurotrophic factors (NTFs) activity, especially brain-derived neurotrophic factors and glial cell-derived neurotrophic factors, could prevent or halt the progress of neurodegeneration in Parkinson's disease (PD).Systematically, the loss of dopaminergic neurons and reduced NTFs mRNA expressions induced by MPTP was ameliorated to a significant extent by pretreatment with GE.We found that GE confers a potent neuroprotective agent against MPTP-induced dopaminergic denervation and may become a potential therapeutic agent for PD and/or its progression.

View Article: PubMed Central - PubMed

Affiliation: Division of Biochemistry, Faculty of Medicine, Raja Muthaiah Medical College, Annamalai University, 608 002, Annamalainagar, Tamil Nadu, India.

ABSTRACT
Many experiments affirm the notion that augmentation of neurotrophic factors (NTFs) activity, especially brain-derived neurotrophic factors and glial cell-derived neurotrophic factors, could prevent or halt the progress of neurodegeneration in Parkinson's disease (PD). In this study, we investigated the therapeutic accomplishment of geraniol (GE 100 mg/kg) on 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced mice model of PD. Current investigation proved that pretreatment with GE ameliorates the MPTP-induced alterations in behavioral, biochemical, immunohistochemical, and immunoblotting manifestations in mice. Systematically, the loss of dopaminergic neurons and reduced NTFs mRNA expressions induced by MPTP was ameliorated to a significant extent by pretreatment with GE. We found that GE confers a potent neuroprotective agent against MPTP-induced dopaminergic denervation and may become a potential therapeutic agent for PD and/or its progression.

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a Western blot analysis of TH, DAT, and VMAT2 in ST of control and experimental mice. b The band density was quantified by scanning densitometry. Bar graph shows the comparison among groups. Values are expressed as mean ± SD of three mice per group. aP < 0.05, compared with the control. bP < 0.05, compared with the MPTP control group
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Fig7: a Western blot analysis of TH, DAT, and VMAT2 in ST of control and experimental mice. b The band density was quantified by scanning densitometry. Bar graph shows the comparison among groups. Values are expressed as mean ± SD of three mice per group. aP < 0.05, compared with the control. bP < 0.05, compared with the MPTP control group

Mentions: As shown in Fig. 7a, b, MPTP treatment significantly decreased the protein expression of TH, DAT, and VMAT2 in ST as compared to control group (P < 0.05). GE pretreatment restored TH, DAT, and VMAT2 protein generation as compared to the MPTP-treated group of animal (P < 0.05). No significant changes were observed between control and GE alone treated mice.Fig. 7


Geraniol ameliorates the motor behavior and neurotrophic factors inadequacy in MPTP-induced mice model of Parkinson's disease.

Rekha KR, Selvakumar GP, Sethupathy S, Santha K, Sivakamasundari RI - J. Mol. Neurosci. (2013)

a Western blot analysis of TH, DAT, and VMAT2 in ST of control and experimental mice. b The band density was quantified by scanning densitometry. Bar graph shows the comparison among groups. Values are expressed as mean ± SD of three mice per group. aP < 0.05, compared with the control. bP < 0.05, compared with the MPTP control group
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3824202&req=5

Fig7: a Western blot analysis of TH, DAT, and VMAT2 in ST of control and experimental mice. b The band density was quantified by scanning densitometry. Bar graph shows the comparison among groups. Values are expressed as mean ± SD of three mice per group. aP < 0.05, compared with the control. bP < 0.05, compared with the MPTP control group
Mentions: As shown in Fig. 7a, b, MPTP treatment significantly decreased the protein expression of TH, DAT, and VMAT2 in ST as compared to control group (P < 0.05). GE pretreatment restored TH, DAT, and VMAT2 protein generation as compared to the MPTP-treated group of animal (P < 0.05). No significant changes were observed between control and GE alone treated mice.Fig. 7

Bottom Line: Many experiments affirm the notion that augmentation of neurotrophic factors (NTFs) activity, especially brain-derived neurotrophic factors and glial cell-derived neurotrophic factors, could prevent or halt the progress of neurodegeneration in Parkinson's disease (PD).Systematically, the loss of dopaminergic neurons and reduced NTFs mRNA expressions induced by MPTP was ameliorated to a significant extent by pretreatment with GE.We found that GE confers a potent neuroprotective agent against MPTP-induced dopaminergic denervation and may become a potential therapeutic agent for PD and/or its progression.

View Article: PubMed Central - PubMed

Affiliation: Division of Biochemistry, Faculty of Medicine, Raja Muthaiah Medical College, Annamalai University, 608 002, Annamalainagar, Tamil Nadu, India.

ABSTRACT
Many experiments affirm the notion that augmentation of neurotrophic factors (NTFs) activity, especially brain-derived neurotrophic factors and glial cell-derived neurotrophic factors, could prevent or halt the progress of neurodegeneration in Parkinson's disease (PD). In this study, we investigated the therapeutic accomplishment of geraniol (GE 100 mg/kg) on 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced mice model of PD. Current investigation proved that pretreatment with GE ameliorates the MPTP-induced alterations in behavioral, biochemical, immunohistochemical, and immunoblotting manifestations in mice. Systematically, the loss of dopaminergic neurons and reduced NTFs mRNA expressions induced by MPTP was ameliorated to a significant extent by pretreatment with GE. We found that GE confers a potent neuroprotective agent against MPTP-induced dopaminergic denervation and may become a potential therapeutic agent for PD and/or its progression.

Show MeSH
Related in: MedlinePlus