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Geraniol ameliorates the motor behavior and neurotrophic factors inadequacy in MPTP-induced mice model of Parkinson's disease.

Rekha KR, Selvakumar GP, Sethupathy S, Santha K, Sivakamasundari RI - J. Mol. Neurosci. (2013)

Bottom Line: Many experiments affirm the notion that augmentation of neurotrophic factors (NTFs) activity, especially brain-derived neurotrophic factors and glial cell-derived neurotrophic factors, could prevent or halt the progress of neurodegeneration in Parkinson's disease (PD).Systematically, the loss of dopaminergic neurons and reduced NTFs mRNA expressions induced by MPTP was ameliorated to a significant extent by pretreatment with GE.We found that GE confers a potent neuroprotective agent against MPTP-induced dopaminergic denervation and may become a potential therapeutic agent for PD and/or its progression.

View Article: PubMed Central - PubMed

Affiliation: Division of Biochemistry, Faculty of Medicine, Raja Muthaiah Medical College, Annamalai University, 608 002, Annamalainagar, Tamil Nadu, India.

ABSTRACT
Many experiments affirm the notion that augmentation of neurotrophic factors (NTFs) activity, especially brain-derived neurotrophic factors and glial cell-derived neurotrophic factors, could prevent or halt the progress of neurodegeneration in Parkinson's disease (PD). In this study, we investigated the therapeutic accomplishment of geraniol (GE 100 mg/kg) on 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced mice model of PD. Current investigation proved that pretreatment with GE ameliorates the MPTP-induced alterations in behavioral, biochemical, immunohistochemical, and immunoblotting manifestations in mice. Systematically, the loss of dopaminergic neurons and reduced NTFs mRNA expressions induced by MPTP was ameliorated to a significant extent by pretreatment with GE. We found that GE confers a potent neuroprotective agent against MPTP-induced dopaminergic denervation and may become a potential therapeutic agent for PD and/or its progression.

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a BDNF and GDNF mRNA expression level changes in ST of control and experimental mice, and β-actin and GAPDH mRNA were used as housekeeping gene for the normalization of mRNA expressions. b Quantification graphs values are expressed as mean ± SD of three mice per group. aP < 0.05, compared with the control. bP < 0.05, compared with the MPTP control group
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Fig5: a BDNF and GDNF mRNA expression level changes in ST of control and experimental mice, and β-actin and GAPDH mRNA were used as housekeeping gene for the normalization of mRNA expressions. b Quantification graphs values are expressed as mean ± SD of three mice per group. aP < 0.05, compared with the control. bP < 0.05, compared with the MPTP control group

Mentions: The mRNA and proteins expressions of BDNF and GDNF revealed that the MPTP treatment significantly decreased mRNA (Fig. 5a, b) and protein expression level (Fig. 6a, b) of BDNF and GDNF as compared to control group, but GE pretreatment retained both expression and production of BDNF and GDNF activity as compared to the MPTP-treated group of mice (P < 0.05). No significant changes were observed between control and GE alone treated mice.Fig. 5


Geraniol ameliorates the motor behavior and neurotrophic factors inadequacy in MPTP-induced mice model of Parkinson's disease.

Rekha KR, Selvakumar GP, Sethupathy S, Santha K, Sivakamasundari RI - J. Mol. Neurosci. (2013)

a BDNF and GDNF mRNA expression level changes in ST of control and experimental mice, and β-actin and GAPDH mRNA were used as housekeeping gene for the normalization of mRNA expressions. b Quantification graphs values are expressed as mean ± SD of three mice per group. aP < 0.05, compared with the control. bP < 0.05, compared with the MPTP control group
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3824202&req=5

Fig5: a BDNF and GDNF mRNA expression level changes in ST of control and experimental mice, and β-actin and GAPDH mRNA were used as housekeeping gene for the normalization of mRNA expressions. b Quantification graphs values are expressed as mean ± SD of three mice per group. aP < 0.05, compared with the control. bP < 0.05, compared with the MPTP control group
Mentions: The mRNA and proteins expressions of BDNF and GDNF revealed that the MPTP treatment significantly decreased mRNA (Fig. 5a, b) and protein expression level (Fig. 6a, b) of BDNF and GDNF as compared to control group, but GE pretreatment retained both expression and production of BDNF and GDNF activity as compared to the MPTP-treated group of mice (P < 0.05). No significant changes were observed between control and GE alone treated mice.Fig. 5

Bottom Line: Many experiments affirm the notion that augmentation of neurotrophic factors (NTFs) activity, especially brain-derived neurotrophic factors and glial cell-derived neurotrophic factors, could prevent or halt the progress of neurodegeneration in Parkinson's disease (PD).Systematically, the loss of dopaminergic neurons and reduced NTFs mRNA expressions induced by MPTP was ameliorated to a significant extent by pretreatment with GE.We found that GE confers a potent neuroprotective agent against MPTP-induced dopaminergic denervation and may become a potential therapeutic agent for PD and/or its progression.

View Article: PubMed Central - PubMed

Affiliation: Division of Biochemistry, Faculty of Medicine, Raja Muthaiah Medical College, Annamalai University, 608 002, Annamalainagar, Tamil Nadu, India.

ABSTRACT
Many experiments affirm the notion that augmentation of neurotrophic factors (NTFs) activity, especially brain-derived neurotrophic factors and glial cell-derived neurotrophic factors, could prevent or halt the progress of neurodegeneration in Parkinson's disease (PD). In this study, we investigated the therapeutic accomplishment of geraniol (GE 100 mg/kg) on 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced mice model of PD. Current investigation proved that pretreatment with GE ameliorates the MPTP-induced alterations in behavioral, biochemical, immunohistochemical, and immunoblotting manifestations in mice. Systematically, the loss of dopaminergic neurons and reduced NTFs mRNA expressions induced by MPTP was ameliorated to a significant extent by pretreatment with GE. We found that GE confers a potent neuroprotective agent against MPTP-induced dopaminergic denervation and may become a potential therapeutic agent for PD and/or its progression.

Show MeSH
Related in: MedlinePlus