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Geraniol ameliorates the motor behavior and neurotrophic factors inadequacy in MPTP-induced mice model of Parkinson's disease.

Rekha KR, Selvakumar GP, Sethupathy S, Santha K, Sivakamasundari RI - J. Mol. Neurosci. (2013)

Bottom Line: Many experiments affirm the notion that augmentation of neurotrophic factors (NTFs) activity, especially brain-derived neurotrophic factors and glial cell-derived neurotrophic factors, could prevent or halt the progress of neurodegeneration in Parkinson's disease (PD).Systematically, the loss of dopaminergic neurons and reduced NTFs mRNA expressions induced by MPTP was ameliorated to a significant extent by pretreatment with GE.We found that GE confers a potent neuroprotective agent against MPTP-induced dopaminergic denervation and may become a potential therapeutic agent for PD and/or its progression.

View Article: PubMed Central - PubMed

Affiliation: Division of Biochemistry, Faculty of Medicine, Raja Muthaiah Medical College, Annamalai University, 608 002, Annamalainagar, Tamil Nadu, India.

ABSTRACT
Many experiments affirm the notion that augmentation of neurotrophic factors (NTFs) activity, especially brain-derived neurotrophic factors and glial cell-derived neurotrophic factors, could prevent or halt the progress of neurodegeneration in Parkinson's disease (PD). In this study, we investigated the therapeutic accomplishment of geraniol (GE 100 mg/kg) on 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced mice model of PD. Current investigation proved that pretreatment with GE ameliorates the MPTP-induced alterations in behavioral, biochemical, immunohistochemical, and immunoblotting manifestations in mice. Systematically, the loss of dopaminergic neurons and reduced NTFs mRNA expressions induced by MPTP was ameliorated to a significant extent by pretreatment with GE. We found that GE confers a potent neuroprotective agent against MPTP-induced dopaminergic denervation and may become a potential therapeutic agent for PD and/or its progression.

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Drag test performance after the acute regimen of GE and MPTP: Pretreated with GE to MPTP group a profound improvement in sensory motor performance. Values are given as mean ± SD for six mice in each group. aP < 0.05 compared to the control, bP < 0.05 compared to the MPTP control
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Fig2: Drag test performance after the acute regimen of GE and MPTP: Pretreated with GE to MPTP group a profound improvement in sensory motor performance. Values are given as mean ± SD for six mice in each group. aP < 0.05 compared to the control, bP < 0.05 compared to the MPTP control

Mentions: The results of spontaneous motor activity performance by behavioral tests were shown in Figs. 1, 2, and 3, respectively. Compared with control mice, the MPTP-treated mice displayed a significant decrease in spontaneous motor activity by latency to fall of the rotarod test, reduce forepaw stride distance, and decreased the number of steps in footprint test (P < 0.05). However, GE pretreatment significantly ameliorated these behavioral deficits induced by MPTP toxicity (P < 0.05)Fig. 1


Geraniol ameliorates the motor behavior and neurotrophic factors inadequacy in MPTP-induced mice model of Parkinson's disease.

Rekha KR, Selvakumar GP, Sethupathy S, Santha K, Sivakamasundari RI - J. Mol. Neurosci. (2013)

Drag test performance after the acute regimen of GE and MPTP: Pretreated with GE to MPTP group a profound improvement in sensory motor performance. Values are given as mean ± SD for six mice in each group. aP < 0.05 compared to the control, bP < 0.05 compared to the MPTP control
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3824202&req=5

Fig2: Drag test performance after the acute regimen of GE and MPTP: Pretreated with GE to MPTP group a profound improvement in sensory motor performance. Values are given as mean ± SD for six mice in each group. aP < 0.05 compared to the control, bP < 0.05 compared to the MPTP control
Mentions: The results of spontaneous motor activity performance by behavioral tests were shown in Figs. 1, 2, and 3, respectively. Compared with control mice, the MPTP-treated mice displayed a significant decrease in spontaneous motor activity by latency to fall of the rotarod test, reduce forepaw stride distance, and decreased the number of steps in footprint test (P < 0.05). However, GE pretreatment significantly ameliorated these behavioral deficits induced by MPTP toxicity (P < 0.05)Fig. 1

Bottom Line: Many experiments affirm the notion that augmentation of neurotrophic factors (NTFs) activity, especially brain-derived neurotrophic factors and glial cell-derived neurotrophic factors, could prevent or halt the progress of neurodegeneration in Parkinson's disease (PD).Systematically, the loss of dopaminergic neurons and reduced NTFs mRNA expressions induced by MPTP was ameliorated to a significant extent by pretreatment with GE.We found that GE confers a potent neuroprotective agent against MPTP-induced dopaminergic denervation and may become a potential therapeutic agent for PD and/or its progression.

View Article: PubMed Central - PubMed

Affiliation: Division of Biochemistry, Faculty of Medicine, Raja Muthaiah Medical College, Annamalai University, 608 002, Annamalainagar, Tamil Nadu, India.

ABSTRACT
Many experiments affirm the notion that augmentation of neurotrophic factors (NTFs) activity, especially brain-derived neurotrophic factors and glial cell-derived neurotrophic factors, could prevent or halt the progress of neurodegeneration in Parkinson's disease (PD). In this study, we investigated the therapeutic accomplishment of geraniol (GE 100 mg/kg) on 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced mice model of PD. Current investigation proved that pretreatment with GE ameliorates the MPTP-induced alterations in behavioral, biochemical, immunohistochemical, and immunoblotting manifestations in mice. Systematically, the loss of dopaminergic neurons and reduced NTFs mRNA expressions induced by MPTP was ameliorated to a significant extent by pretreatment with GE. We found that GE confers a potent neuroprotective agent against MPTP-induced dopaminergic denervation and may become a potential therapeutic agent for PD and/or its progression.

Show MeSH
Related in: MedlinePlus