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Epidemiology of vasculitides: differences between Japan, Europe and North America.

Kobayashi S, Fujimoto S - Clin. Exp. Nephrol. (2013)

Bottom Line: Takayasu's arteritis occurs frequently in Japan, unlike giant cell arteritis.These differences may be attributed to differences in latitude and genetic backgrounds.These findings provide useful information on the aetiology and pathogenesis of primary systemic vasculitides in various geographical regions.

View Article: PubMed Central - PubMed

Affiliation: Rheumatology, Department of Internal Medicine, Juntendo University Koshigaya Hospital, 560 Fukuroyama, Koshigaya, Saitama, 343-0032, Japan, shigeto@juntendo.ac.jp.

ABSTRACT
The epidemiology of systemic vasculitides differs between Japan, Europe and North America. Takayasu's arteritis occurs frequently in Japan, unlike giant cell arteritis. A collaborative international study comparing the epidemiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis between Japan and the United Kingdom (UK) demonstrated that microscopic polyangiitis and myeloperoxidase-ANCA were more common in Japan, whereas granulomatosis with polyangiitis and pronase 3-ANCA were more common in the UK. These differences may be attributed to differences in latitude and genetic backgrounds. These findings provide useful information on the aetiology and pathogenesis of primary systemic vasculitides in various geographical regions.

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Geographical differences in the incidences of vasculitides. GCA and GPA occur more frequently in North Europe and North America whereas Takayasu arteritis and MPA occur more frequently in Japan
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Fig1: Geographical differences in the incidences of vasculitides. GCA and GPA occur more frequently in North Europe and North America whereas Takayasu arteritis and MPA occur more frequently in Japan

Mentions: Japan is located between the latitudes of 26–45°N. Asahikawa city (43.5°N) on Hokkaido Island is close to the latitude of Lugo, Spain (42°N) [1]. On this island, there are more patients with microscopic polyangiitis (MPA); a higher number of patients with AAV are MPO-ANCA-positive than granulomatosis with polyangiitis (GPA)- or pronase 3 (PR3)-positive [1]. These data are compatible with the latitude theory of AAV [3] (Fig. 1).Fig. 1


Epidemiology of vasculitides: differences between Japan, Europe and North America.

Kobayashi S, Fujimoto S - Clin. Exp. Nephrol. (2013)

Geographical differences in the incidences of vasculitides. GCA and GPA occur more frequently in North Europe and North America whereas Takayasu arteritis and MPA occur more frequently in Japan
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3824199&req=5

Fig1: Geographical differences in the incidences of vasculitides. GCA and GPA occur more frequently in North Europe and North America whereas Takayasu arteritis and MPA occur more frequently in Japan
Mentions: Japan is located between the latitudes of 26–45°N. Asahikawa city (43.5°N) on Hokkaido Island is close to the latitude of Lugo, Spain (42°N) [1]. On this island, there are more patients with microscopic polyangiitis (MPA); a higher number of patients with AAV are MPO-ANCA-positive than granulomatosis with polyangiitis (GPA)- or pronase 3 (PR3)-positive [1]. These data are compatible with the latitude theory of AAV [3] (Fig. 1).Fig. 1

Bottom Line: Takayasu's arteritis occurs frequently in Japan, unlike giant cell arteritis.These differences may be attributed to differences in latitude and genetic backgrounds.These findings provide useful information on the aetiology and pathogenesis of primary systemic vasculitides in various geographical regions.

View Article: PubMed Central - PubMed

Affiliation: Rheumatology, Department of Internal Medicine, Juntendo University Koshigaya Hospital, 560 Fukuroyama, Koshigaya, Saitama, 343-0032, Japan, shigeto@juntendo.ac.jp.

ABSTRACT
The epidemiology of systemic vasculitides differs between Japan, Europe and North America. Takayasu's arteritis occurs frequently in Japan, unlike giant cell arteritis. A collaborative international study comparing the epidemiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis between Japan and the United Kingdom (UK) demonstrated that microscopic polyangiitis and myeloperoxidase-ANCA were more common in Japan, whereas granulomatosis with polyangiitis and pronase 3-ANCA were more common in the UK. These differences may be attributed to differences in latitude and genetic backgrounds. These findings provide useful information on the aetiology and pathogenesis of primary systemic vasculitides in various geographical regions.

Show MeSH
Related in: MedlinePlus