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Thymus and mediastinal node involvement in childhood Langerhans cell histiocytosis: long-term follow-up from the French national cohort.

Ducassou S, Seyrig F, Thomas C, Lambilliotte A, Marec-Berard P, Berger C, Plat G, Brugiere L, Ouache M, Barkaoui M, Armari-Alla C, Lutz P, Leverger G, Rialland X, Mansuy L, Pacquement H, Jeziorski E, Gandemer V, Chalard F, Chateil JF, Tazi A, Emile JF, Donadieu J, Investigators of the French LCH Study Gro - Pediatr Blood Cancer (2013)

Bottom Line: Thirteen cases (35%) were diagnosed because of MI-related symptoms, including respiratory distress (N = 4), superior venous cava syndrome (N = 2), and/or cough and polypnea (N = 10).The overall 5-year survival was 87.1%, and immunodeficiency was not detected as a sequel.MI in LCH mainly occurs in young children, and diagnosis was based on CT showing thymus enlargement and calcifications.

View Article: PubMed Central - PubMed

Affiliation: Service D'hémato Oncologie Pédiatrique, CHU de Strasbourg, Strasbourg, France; Service D'hémato Oncologie Pédiatrique, CHU de Bordeaux, Bordeaux, France.

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Evolution of lymphocyte count and CD3, CD4, and CD8 subsets at diagnosis, during therapy, and at the completion of the therapy in patient UPN 1506627.
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fig01: Evolution of lymphocyte count and CD3, CD4, and CD8 subsets at diagnosis, during therapy, and at the completion of the therapy in patient UPN 1506627.

Mentions: At diagnosis, six patients had lymphopenia with deficiency of CD4 and CD8 T lymphocytes, which was profound in two cases among the 14 patients assessable for these criteria. Figure 1 depicts the lymphocyte status of patient UPN 1506627, both at diagnosis and during therapy; this patient's iconography is reported in Figure 2A,B. One child had hypogammaglobulinemia. In the other patients, the immunological control was normal or not checked.


Thymus and mediastinal node involvement in childhood Langerhans cell histiocytosis: long-term follow-up from the French national cohort.

Ducassou S, Seyrig F, Thomas C, Lambilliotte A, Marec-Berard P, Berger C, Plat G, Brugiere L, Ouache M, Barkaoui M, Armari-Alla C, Lutz P, Leverger G, Rialland X, Mansuy L, Pacquement H, Jeziorski E, Gandemer V, Chalard F, Chateil JF, Tazi A, Emile JF, Donadieu J, Investigators of the French LCH Study Gro - Pediatr Blood Cancer (2013)

Evolution of lymphocyte count and CD3, CD4, and CD8 subsets at diagnosis, during therapy, and at the completion of the therapy in patient UPN 1506627.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3824083&req=5

fig01: Evolution of lymphocyte count and CD3, CD4, and CD8 subsets at diagnosis, during therapy, and at the completion of the therapy in patient UPN 1506627.
Mentions: At diagnosis, six patients had lymphopenia with deficiency of CD4 and CD8 T lymphocytes, which was profound in two cases among the 14 patients assessable for these criteria. Figure 1 depicts the lymphocyte status of patient UPN 1506627, both at diagnosis and during therapy; this patient's iconography is reported in Figure 2A,B. One child had hypogammaglobulinemia. In the other patients, the immunological control was normal or not checked.

Bottom Line: Thirteen cases (35%) were diagnosed because of MI-related symptoms, including respiratory distress (N = 4), superior venous cava syndrome (N = 2), and/or cough and polypnea (N = 10).The overall 5-year survival was 87.1%, and immunodeficiency was not detected as a sequel.MI in LCH mainly occurs in young children, and diagnosis was based on CT showing thymus enlargement and calcifications.

View Article: PubMed Central - PubMed

Affiliation: Service D'hémato Oncologie Pédiatrique, CHU de Strasbourg, Strasbourg, France; Service D'hémato Oncologie Pédiatrique, CHU de Bordeaux, Bordeaux, France.

Show MeSH
Related in: MedlinePlus