The 6-minute walk test and other endpoints in Duchenne muscular dystrophy: longitudinal natural history observations over 48 weeks from a multicenter study.
Bottom Line: Baseline age (≥7 years), 6MWD, and selected TFT performance are strong predictors of decline in ambulation (Δ6MWD) and time to 10% worsening in 6MWD.A baseline 6MWD of <350 meters was associated with greater functional decline, and loss of ambulation was only seen in those with baseline 6MWD <325 meters.Only 1 of 42 (2.3%) subjects able to stand from supine lost ambulation.
Affiliation: Department of Physical Medicine and Rehabilitation, University of California Davis School of Medicine, Davis, California, 95817, USA.Show MeSH
Related in: MedlinePlus
Mentions: Figure 9a–c shows the effect of baseline TFTs on time to 10% progression in 6MWD. For all 3 TFTs there is a significant predicted value of time to perform the task at baseline and proportion progressing ≥10% on 6MWD. The effect of baseline 6MWD and percent predicted 6MWD on the proportion of patients who show persistent ≥10% decline in 6MWD over the subsequent 48 weeks is shown in Figure 10a and b. Initial 6MWD of <325 m and <55% predicted were associated with a greater likelihood of progressing ≥10% in 6MWD over 48 weeks.
Affiliation: Department of Physical Medicine and Rehabilitation, University of California Davis School of Medicine, Davis, California, 95817, USA.