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The 6-minute walk test and other endpoints in Duchenne muscular dystrophy: longitudinal natural history observations over 48 weeks from a multicenter study.

McDonald CM, Henricson EK, Abresch RT, Florence JM, Eagle M, Gappmaier E, Glanzman AM, PTC124-GD-007-DMD Study GroupSpiegel R, Barth J, Elfring G, Reha A, Peltz S - Muscle Nerve (2013)

Bottom Line: Baseline age (≥7 years), 6MWD, and selected TFT performance are strong predictors of decline in ambulation (Δ6MWD) and time to 10% worsening in 6MWD.A baseline 6MWD of <350 meters was associated with greater functional decline, and loss of ambulation was only seen in those with baseline 6MWD <325 meters.Only 1 of 42 (2.3%) subjects able to stand from supine lost ambulation.

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Medicine and Rehabilitation, University of California Davis School of Medicine, Davis, California, 95817, USA.

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Time to persistent 10% 6MWD worsening in 57 DMD patients. Note that the relative proportion of patients who reached the 10% progression milestone was constant over 48 weeks (26.3% patients declined 10% or more during the first 24 weeks; 23.8% of the remaining patients declined 10% or more from weeks 24–48).
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fig08: Time to persistent 10% 6MWD worsening in 57 DMD patients. Note that the relative proportion of patients who reached the 10% progression milestone was constant over 48 weeks (26.3% patients declined 10% or more during the first 24 weeks; 23.8% of the remaining patients declined 10% or more from weeks 24–48).

Mentions: Using a time-to-event approach, the time to persistent 10% 6MWD worsening is shown in Figure 8. The relative proportion of patients who reached the 10% progression milestone appears to have been constant over 48 weeks (26.3% of patients declined 10% or more during the first 24 weeks, and 23.8% of the remaining patients declined 10% or more from 24 to 48 weeks). This time-to-event approach allows for determination of the time to disease progression relative to the patients' baseline values regardless of whether ambulation is lost and patients have transitioned to a wheelchair.


The 6-minute walk test and other endpoints in Duchenne muscular dystrophy: longitudinal natural history observations over 48 weeks from a multicenter study.

McDonald CM, Henricson EK, Abresch RT, Florence JM, Eagle M, Gappmaier E, Glanzman AM, PTC124-GD-007-DMD Study GroupSpiegel R, Barth J, Elfring G, Reha A, Peltz S - Muscle Nerve (2013)

Time to persistent 10% 6MWD worsening in 57 DMD patients. Note that the relative proportion of patients who reached the 10% progression milestone was constant over 48 weeks (26.3% patients declined 10% or more during the first 24 weeks; 23.8% of the remaining patients declined 10% or more from weeks 24–48).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3824082&req=5

fig08: Time to persistent 10% 6MWD worsening in 57 DMD patients. Note that the relative proportion of patients who reached the 10% progression milestone was constant over 48 weeks (26.3% patients declined 10% or more during the first 24 weeks; 23.8% of the remaining patients declined 10% or more from weeks 24–48).
Mentions: Using a time-to-event approach, the time to persistent 10% 6MWD worsening is shown in Figure 8. The relative proportion of patients who reached the 10% progression milestone appears to have been constant over 48 weeks (26.3% of patients declined 10% or more during the first 24 weeks, and 23.8% of the remaining patients declined 10% or more from 24 to 48 weeks). This time-to-event approach allows for determination of the time to disease progression relative to the patients' baseline values regardless of whether ambulation is lost and patients have transitioned to a wheelchair.

Bottom Line: Baseline age (≥7 years), 6MWD, and selected TFT performance are strong predictors of decline in ambulation (Δ6MWD) and time to 10% worsening in 6MWD.A baseline 6MWD of <350 meters was associated with greater functional decline, and loss of ambulation was only seen in those with baseline 6MWD <325 meters.Only 1 of 42 (2.3%) subjects able to stand from supine lost ambulation.

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Medicine and Rehabilitation, University of California Davis School of Medicine, Davis, California, 95817, USA.

Show MeSH
Related in: MedlinePlus