The 6-minute walk test and other endpoints in Duchenne muscular dystrophy: longitudinal natural history observations over 48 weeks from a multicenter study.
Bottom Line: Baseline age (≥7 years), 6MWD, and selected TFT performance are strong predictors of decline in ambulation (Δ6MWD) and time to 10% worsening in 6MWD.A baseline 6MWD of <350 meters was associated with greater functional decline, and loss of ambulation was only seen in those with baseline 6MWD <325 meters.Only 1 of 42 (2.3%) subjects able to stand from supine lost ambulation.
Affiliation: Department of Physical Medicine and Rehabilitation, University of California Davis School of Medicine, Davis, California, 95817, USA.Show MeSH
Related in: MedlinePlus
Mentions: Using a time-to-event approach, the time to persistent 10% 6MWD worsening is shown in Figure 8. The relative proportion of patients who reached the 10% progression milestone appears to have been constant over 48 weeks (26.3% of patients declined 10% or more during the first 24 weeks, and 23.8% of the remaining patients declined 10% or more from 24 to 48 weeks). This time-to-event approach allows for determination of the time to disease progression relative to the patients' baseline values regardless of whether ambulation is lost and patients have transitioned to a wheelchair.
Affiliation: Department of Physical Medicine and Rehabilitation, University of California Davis School of Medicine, Davis, California, 95817, USA.