The 6-minute walk test and other endpoints in Duchenne muscular dystrophy: longitudinal natural history observations over 48 weeks from a multicenter study.
Bottom Line: Baseline age (≥7 years), 6MWD, and selected TFT performance are strong predictors of decline in ambulation (Δ6MWD) and time to 10% worsening in 6MWD.A baseline 6MWD of <350 meters was associated with greater functional decline, and loss of ambulation was only seen in those with baseline 6MWD <325 meters.Only 1 of 42 (2.3%) subjects able to stand from supine lost ambulation.
Affiliation: Department of Physical Medicine and Rehabilitation, University of California Davis School of Medicine, Davis, California, 95817, USA.Show MeSH
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Mentions: For the 40 patients on stable doses of glucocorticoids at the initiation of the study baseline the TFT results [mean (SD)] for 6 subjects <7 years and 34 subjects ≥7 years, respectively, were as follows: time to rise from supine = 4.0 s (1.13) and 12.9 s (12.33); time to climb 4 stairs = 2.5 s (0.67) and 6.6 s (6.30); time to run/walk 10 m = 4.8 s (0.86) and 7.1 s (2.80). Mean changes from baseline ± SEM over 48 weeks are plotted in Figure 2a–c. For all TFTs there was little change over 48 weeks in patients <7 years of age, whereas for patients ≥7 years there were greater changes in TFT values. In general, the SD and SEM of the change scores from baseline increase over time due to variability in disease progression.
Affiliation: Department of Physical Medicine and Rehabilitation, University of California Davis School of Medicine, Davis, California, 95817, USA.