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The 6-minute walk test and other endpoints in Duchenne muscular dystrophy: longitudinal natural history observations over 48 weeks from a multicenter study.

McDonald CM, Henricson EK, Abresch RT, Florence JM, Eagle M, Gappmaier E, Glanzman AM, PTC124-GD-007-DMD Study GroupSpiegel R, Barth J, Elfring G, Reha A, Peltz S - Muscle Nerve (2013)

Bottom Line: Baseline age (≥7 years), 6MWD, and selected TFT performance are strong predictors of decline in ambulation (Δ6MWD) and time to 10% worsening in 6MWD.A baseline 6MWD of <350 meters was associated with greater functional decline, and loss of ambulation was only seen in those with baseline 6MWD <325 meters.Only 1 of 42 (2.3%) subjects able to stand from supine lost ambulation.

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Medicine and Rehabilitation, University of California Davis School of Medicine, Davis, California, 95817, USA.

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(a) Kaplan–Maier survival for time to 10% progression on 6MWD for 3 groups, based on initial 6MWD (<325 m, 325 to <410 m, and ≥410 m). (b) Kaplan–Meier analysis of time to 10% worsening in 6MWD based on initial percent predicted 6MWD at baseline for 3 groups (percent predicted 6MWD <55%, percent predicted 6MWD 55% to <80%, and percent predicted 6MWD ≥80%).
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fig10: (a) Kaplan–Maier survival for time to 10% progression on 6MWD for 3 groups, based on initial 6MWD (<325 m, 325 to <410 m, and ≥410 m). (b) Kaplan–Meier analysis of time to 10% worsening in 6MWD based on initial percent predicted 6MWD at baseline for 3 groups (percent predicted 6MWD <55%, percent predicted 6MWD 55% to <80%, and percent predicted 6MWD ≥80%).

Mentions: Figure 9a–c shows the effect of baseline TFTs on time to 10% progression in 6MWD. For all 3 TFTs there is a significant predicted value of time to perform the task at baseline and proportion progressing ≥10% on 6MWD. The effect of baseline 6MWD and percent predicted 6MWD on the proportion of patients who show persistent ≥10% decline in 6MWD over the subsequent 48 weeks is shown in Figure 10a and b. Initial 6MWD of <325 m and <55% predicted were associated with a greater likelihood of progressing ≥10% in 6MWD over 48 weeks.


The 6-minute walk test and other endpoints in Duchenne muscular dystrophy: longitudinal natural history observations over 48 weeks from a multicenter study.

McDonald CM, Henricson EK, Abresch RT, Florence JM, Eagle M, Gappmaier E, Glanzman AM, PTC124-GD-007-DMD Study GroupSpiegel R, Barth J, Elfring G, Reha A, Peltz S - Muscle Nerve (2013)

(a) Kaplan–Maier survival for time to 10% progression on 6MWD for 3 groups, based on initial 6MWD (<325 m, 325 to <410 m, and ≥410 m). (b) Kaplan–Meier analysis of time to 10% worsening in 6MWD based on initial percent predicted 6MWD at baseline for 3 groups (percent predicted 6MWD <55%, percent predicted 6MWD 55% to <80%, and percent predicted 6MWD ≥80%).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3824082&req=5

fig10: (a) Kaplan–Maier survival for time to 10% progression on 6MWD for 3 groups, based on initial 6MWD (<325 m, 325 to <410 m, and ≥410 m). (b) Kaplan–Meier analysis of time to 10% worsening in 6MWD based on initial percent predicted 6MWD at baseline for 3 groups (percent predicted 6MWD <55%, percent predicted 6MWD 55% to <80%, and percent predicted 6MWD ≥80%).
Mentions: Figure 9a–c shows the effect of baseline TFTs on time to 10% progression in 6MWD. For all 3 TFTs there is a significant predicted value of time to perform the task at baseline and proportion progressing ≥10% on 6MWD. The effect of baseline 6MWD and percent predicted 6MWD on the proportion of patients who show persistent ≥10% decline in 6MWD over the subsequent 48 weeks is shown in Figure 10a and b. Initial 6MWD of <325 m and <55% predicted were associated with a greater likelihood of progressing ≥10% in 6MWD over 48 weeks.

Bottom Line: Baseline age (≥7 years), 6MWD, and selected TFT performance are strong predictors of decline in ambulation (Δ6MWD) and time to 10% worsening in 6MWD.A baseline 6MWD of <350 meters was associated with greater functional decline, and loss of ambulation was only seen in those with baseline 6MWD <325 meters.Only 1 of 42 (2.3%) subjects able to stand from supine lost ambulation.

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Medicine and Rehabilitation, University of California Davis School of Medicine, Davis, California, 95817, USA.

Show MeSH
Related in: MedlinePlus