The 6-minute walk test and other endpoints in Duchenne muscular dystrophy: longitudinal natural history observations over 48 weeks from a multicenter study.
Bottom Line: Baseline age (≥7 years), 6MWD, and selected TFT performance are strong predictors of decline in ambulation (Δ6MWD) and time to 10% worsening in 6MWD.A baseline 6MWD of <350 meters was associated with greater functional decline, and loss of ambulation was only seen in those with baseline 6MWD <325 meters.Only 1 of 42 (2.3%) subjects able to stand from supine lost ambulation.
Affiliation: Department of Physical Medicine and Rehabilitation, University of California Davis School of Medicine, Davis, California, 95817, USA.Show MeSH
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Mentions: Mean strength changes over 48 weeks are shown for myometry in Figure 1. The mean baseline and mean change from baseline at 48 weeks were as follows: knee flexion, 11.06 and +0.38 pounds; knee extension, 12.96 and −1.85 pounds; elbow flexion, 8.14 and −0.35 pounds; elbow extension, 6.77 and −0.51 pounds; and shoulder abduction, 5.76 and −0.28 pounds. There were no significant differences in strength change over 48 weeks for glucocorticoid-treated versus non–glucocorticoid-treated patients.
Affiliation: Department of Physical Medicine and Rehabilitation, University of California Davis School of Medicine, Davis, California, 95817, USA.