Limits...
Unlocking the potential of survival data for model organisms through a new database and online analysis platform: SurvCurv.

Ziehm M, Thornton JM - Aging Cell (2013)

Bottom Line: Understanding the biology of aging is highly desirable because of the benefits for the wide range of aging-related diseases.The database, available at www.ebi.ac.uk/thornton-srv/databases/SurvCurv/, offers various functions including plotting, Cox proportional hazards analysis, mathematical mortality models and statistical tests.It facilitates reanalysis and allows users to analyse their own data and compare it with the largest repository of model-organism data from published experiments, thus unlocking the potential of survival data and demographics in model organisms.

View Article: PubMed Central - PubMed

Affiliation: EMBL - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.

Show MeSH
Survival curves for dFOXO overexpression (dashed) (SurvCurv:490+500), measured control (solid) (SurvCurv:494+504) and historical control with ostensibly inactive genetic constructs from pooled control cohorts of once mated female wDah Drosophila melanogaster at 25 °C fed 1SY food (dotted).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3824079&req=5

fig03: Survival curves for dFOXO overexpression (dashed) (SurvCurv:490+500), measured control (solid) (SurvCurv:494+504) and historical control with ostensibly inactive genetic constructs from pooled control cohorts of once mated female wDah Drosophila melanogaster at 25 °C fed 1SY food (dotted).

Mentions: An example where historical controls might have been helpful is the study of dFOXO overexpression (Giannakou et al., 2007; Fig. 3). Looking only at the measured control and treatment, the conclusion is a clear increase in lifespan when overexpressing dFOXO, and further studies (Hwangbo et al., 2004; Giannakou et al., 2008) support the general statement that dFOXO overexpression can extend lifespan. However, taking into account the survival curve of pooled controls of similar conditions (in this case once mated female wDah flies at 25 °C fed 1SY food), it is quite clear that both measured control and treatment have shorter survival than the historical control. The positive effect of dFOXO overexpression could therefore additionally be seen as partially rescuing some unknown negative effect on lifespan which occurred in the experiment. Further investigation of such findings at the time of the experiment could help uncover unknown interactions of different modulators of aging.


Unlocking the potential of survival data for model organisms through a new database and online analysis platform: SurvCurv.

Ziehm M, Thornton JM - Aging Cell (2013)

Survival curves for dFOXO overexpression (dashed) (SurvCurv:490+500), measured control (solid) (SurvCurv:494+504) and historical control with ostensibly inactive genetic constructs from pooled control cohorts of once mated female wDah Drosophila melanogaster at 25 °C fed 1SY food (dotted).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3824079&req=5

fig03: Survival curves for dFOXO overexpression (dashed) (SurvCurv:490+500), measured control (solid) (SurvCurv:494+504) and historical control with ostensibly inactive genetic constructs from pooled control cohorts of once mated female wDah Drosophila melanogaster at 25 °C fed 1SY food (dotted).
Mentions: An example where historical controls might have been helpful is the study of dFOXO overexpression (Giannakou et al., 2007; Fig. 3). Looking only at the measured control and treatment, the conclusion is a clear increase in lifespan when overexpressing dFOXO, and further studies (Hwangbo et al., 2004; Giannakou et al., 2008) support the general statement that dFOXO overexpression can extend lifespan. However, taking into account the survival curve of pooled controls of similar conditions (in this case once mated female wDah flies at 25 °C fed 1SY food), it is quite clear that both measured control and treatment have shorter survival than the historical control. The positive effect of dFOXO overexpression could therefore additionally be seen as partially rescuing some unknown negative effect on lifespan which occurred in the experiment. Further investigation of such findings at the time of the experiment could help uncover unknown interactions of different modulators of aging.

Bottom Line: Understanding the biology of aging is highly desirable because of the benefits for the wide range of aging-related diseases.The database, available at www.ebi.ac.uk/thornton-srv/databases/SurvCurv/, offers various functions including plotting, Cox proportional hazards analysis, mathematical mortality models and statistical tests.It facilitates reanalysis and allows users to analyse their own data and compare it with the largest repository of model-organism data from published experiments, thus unlocking the potential of survival data and demographics in model organisms.

View Article: PubMed Central - PubMed

Affiliation: EMBL - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.

Show MeSH