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Elucidating neuroanatomical alterations in the at risk mental state and first episode psychosis: a combined voxel-based morphometry and voxel-based cortical thickness study.

Benetti S, Pettersson-Yeo W, Hutton C, Catani M, Williams SC, Allen P, Kambeitz-Ilankovic LM, McGuire P, Mechelli A - Schizophr. Res. (2013)

Bottom Line: Statistical inferences were made at P<0.05 after correction for multiple comparisons.Cortical thinning in the right superior temporal gyrus was observed in both individuals at high risk of developing psychosis and patients with a first episode of the disorder, and therefore is likely to represent a marker of vulnerability.In contrast, the right posterior cingulate cortex showed cortical thinning in FEP patients relative to individuals at high risk, and therefore appears to be implicated in the onset of the disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychosis Studies, King's College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK. Electronic address: stefania.benetti@kcl.ac.uk.

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Related in: MedlinePlus

Left. Brain regions showing cortical thinning in both ARMS and FEP participants compared to healthy controls (P < 0.001uncorrected, for display purposes). T-scores are shown in the coloured bar. Right. Cortical thickness (CT) estimates in the right superior temporal cortex are shown for the three groups with the dashed lines indicating group CT means. Cortical thickness is measured in terms of mm between the inner and outer surfaces of grey matter.
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f0005: Left. Brain regions showing cortical thinning in both ARMS and FEP participants compared to healthy controls (P < 0.001uncorrected, for display purposes). T-scores are shown in the coloured bar. Right. Cortical thickness (CT) estimates in the right superior temporal cortex are shown for the three groups with the dashed lines indicating group CT means. Cortical thickness is measured in terms of mm between the inner and outer surfaces of grey matter.

Mentions: Compared to healthy controls, individuals with an ARMS and FEP patients showed thinner cortex in the right STG (BA 42) (P < 0.05, corrected; Table 2; Fig. 1). In contrast, there were no regions with thicker cortex in the two clinical groups compared to the control group. When the ARMS and FEP groups were compared, the latter showed reduced CT in the right PCC (P < 0.05, corrected; Fig. 2; Table 2); in contrast, no areas showed an effect in the opposite direction.


Elucidating neuroanatomical alterations in the at risk mental state and first episode psychosis: a combined voxel-based morphometry and voxel-based cortical thickness study.

Benetti S, Pettersson-Yeo W, Hutton C, Catani M, Williams SC, Allen P, Kambeitz-Ilankovic LM, McGuire P, Mechelli A - Schizophr. Res. (2013)

Left. Brain regions showing cortical thinning in both ARMS and FEP participants compared to healthy controls (P < 0.001uncorrected, for display purposes). T-scores are shown in the coloured bar. Right. Cortical thickness (CT) estimates in the right superior temporal cortex are shown for the three groups with the dashed lines indicating group CT means. Cortical thickness is measured in terms of mm between the inner and outer surfaces of grey matter.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3824077&req=5

f0005: Left. Brain regions showing cortical thinning in both ARMS and FEP participants compared to healthy controls (P < 0.001uncorrected, for display purposes). T-scores are shown in the coloured bar. Right. Cortical thickness (CT) estimates in the right superior temporal cortex are shown for the three groups with the dashed lines indicating group CT means. Cortical thickness is measured in terms of mm between the inner and outer surfaces of grey matter.
Mentions: Compared to healthy controls, individuals with an ARMS and FEP patients showed thinner cortex in the right STG (BA 42) (P < 0.05, corrected; Table 2; Fig. 1). In contrast, there were no regions with thicker cortex in the two clinical groups compared to the control group. When the ARMS and FEP groups were compared, the latter showed reduced CT in the right PCC (P < 0.05, corrected; Fig. 2; Table 2); in contrast, no areas showed an effect in the opposite direction.

Bottom Line: Statistical inferences were made at P<0.05 after correction for multiple comparisons.Cortical thinning in the right superior temporal gyrus was observed in both individuals at high risk of developing psychosis and patients with a first episode of the disorder, and therefore is likely to represent a marker of vulnerability.In contrast, the right posterior cingulate cortex showed cortical thinning in FEP patients relative to individuals at high risk, and therefore appears to be implicated in the onset of the disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychosis Studies, King's College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK. Electronic address: stefania.benetti@kcl.ac.uk.

Show MeSH
Related in: MedlinePlus