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Decreased survival of newborn neurons in the dorsal hippocampus after neonatal LPS exposure in mice.

Järlestedt K, Naylor AS, Dean J, Hagberg H, Mallard C - Neuroscience (2013)

Bottom Line: In contrast, the number of neurons and astrocytes that were born after LPS injection were reduced on P 41.The LPS-induced reduction in cell numbers was specific for the dorsal hippocampus.The reduction in cell survival could be attributed to less cell survival in the dorsal hippocampus, but had no effect on learning and memory in the young adult.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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LPS reduces the survival of newborn cells specifically in the dorsal hippocampus. (A) The area of the dorsal and ventral granule cell layer (GCL) was similar in LPS-exposed pups compared to saline control at P60. (B–D) Survival of BrdU-positive cells, labeled at P11, 48 h after LPS, was significantly reduced in the dorsal hippocampus at P60 compared to sham animals. (B) There was no effect by neonatal LPS on survival of BrdU labeled cells in the ventral hippocampus at P60. Group means ± SEM. ∗P < 0.05, ∗∗P < 0.01.
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f0025: LPS reduces the survival of newborn cells specifically in the dorsal hippocampus. (A) The area of the dorsal and ventral granule cell layer (GCL) was similar in LPS-exposed pups compared to saline control at P60. (B–D) Survival of BrdU-positive cells, labeled at P11, 48 h after LPS, was significantly reduced in the dorsal hippocampus at P60 compared to sham animals. (B) There was no effect by neonatal LPS on survival of BrdU labeled cells in the ventral hippocampus at P60. Group means ± SEM. ∗P < 0.05, ∗∗P < 0.01.

Mentions: Lesions in the dorsal hippocampus have been associated with learning deficits. We therefore investigated cell survival in dorsal and ventral hippocampi respectively at P60 following neonatal (P9) LPS (n = 13) or saline (n = 10) administration (Fig 1D). There was no difference in the area of either the dorsal or ventral GCL in LPS-exposed pups compared to saline control at P60 (Fig 5A, p > 0.05). In contrast, the survival of BrdU-positive cells was significantly reduced in the dorsal hippocampus at P60 following neonatal LPS (saline: 4029 ± 357, n = 10 vs. LPS 2570 ± 374, n = 13, P < 0.01, Fig 5B, C, D), but not in the ventral hippocampus (Fig 5B, p > 0.05).


Decreased survival of newborn neurons in the dorsal hippocampus after neonatal LPS exposure in mice.

Järlestedt K, Naylor AS, Dean J, Hagberg H, Mallard C - Neuroscience (2013)

LPS reduces the survival of newborn cells specifically in the dorsal hippocampus. (A) The area of the dorsal and ventral granule cell layer (GCL) was similar in LPS-exposed pups compared to saline control at P60. (B–D) Survival of BrdU-positive cells, labeled at P11, 48 h after LPS, was significantly reduced in the dorsal hippocampus at P60 compared to sham animals. (B) There was no effect by neonatal LPS on survival of BrdU labeled cells in the ventral hippocampus at P60. Group means ± SEM. ∗P < 0.05, ∗∗P < 0.01.
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Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC3824076&req=5

f0025: LPS reduces the survival of newborn cells specifically in the dorsal hippocampus. (A) The area of the dorsal and ventral granule cell layer (GCL) was similar in LPS-exposed pups compared to saline control at P60. (B–D) Survival of BrdU-positive cells, labeled at P11, 48 h after LPS, was significantly reduced in the dorsal hippocampus at P60 compared to sham animals. (B) There was no effect by neonatal LPS on survival of BrdU labeled cells in the ventral hippocampus at P60. Group means ± SEM. ∗P < 0.05, ∗∗P < 0.01.
Mentions: Lesions in the dorsal hippocampus have been associated with learning deficits. We therefore investigated cell survival in dorsal and ventral hippocampi respectively at P60 following neonatal (P9) LPS (n = 13) or saline (n = 10) administration (Fig 1D). There was no difference in the area of either the dorsal or ventral GCL in LPS-exposed pups compared to saline control at P60 (Fig 5A, p > 0.05). In contrast, the survival of BrdU-positive cells was significantly reduced in the dorsal hippocampus at P60 following neonatal LPS (saline: 4029 ± 357, n = 10 vs. LPS 2570 ± 374, n = 13, P < 0.01, Fig 5B, C, D), but not in the ventral hippocampus (Fig 5B, p > 0.05).

Bottom Line: In contrast, the number of neurons and astrocytes that were born after LPS injection were reduced on P 41.The LPS-induced reduction in cell numbers was specific for the dorsal hippocampus.The reduction in cell survival could be attributed to less cell survival in the dorsal hippocampus, but had no effect on learning and memory in the young adult.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Show MeSH
Related in: MedlinePlus