Decreased survival of newborn neurons in the dorsal hippocampus after neonatal LPS exposure in mice.
Bottom Line: In contrast, the number of neurons and astrocytes that were born after LPS injection were reduced on P 41.The LPS-induced reduction in cell numbers was specific for the dorsal hippocampus.The reduction in cell survival could be attributed to less cell survival in the dorsal hippocampus, but had no effect on learning and memory in the young adult.
Affiliation: Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.Show MeSH
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Mentions: Lesions in the dorsal hippocampus have been associated with learning deficits. We therefore investigated cell survival in dorsal and ventral hippocampi respectively at P60 following neonatal (P9) LPS (n = 13) or saline (n = 10) administration (Fig 1D). There was no difference in the area of either the dorsal or ventral GCL in LPS-exposed pups compared to saline control at P60 (Fig 5A, p > 0.05). In contrast, the survival of BrdU-positive cells was significantly reduced in the dorsal hippocampus at P60 following neonatal LPS (saline: 4029 ± 357, n = 10 vs. LPS 2570 ± 374, n = 13, P < 0.01, Fig 5B, C, D), but not in the ventral hippocampus (Fig 5B, p > 0.05).
Affiliation: Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.