Decreased survival of newborn neurons in the dorsal hippocampus after neonatal LPS exposure in mice.
Bottom Line: In contrast, the number of neurons and astrocytes that were born after LPS injection were reduced on P 41.The LPS-induced reduction in cell numbers was specific for the dorsal hippocampus.The reduction in cell survival could be attributed to less cell survival in the dorsal hippocampus, but had no effect on learning and memory in the young adult.
Affiliation: Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.Show MeSH
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Mentions: To further understand the effect of cell survival on cells born after LPS, we analyzed the effect of LPS administration on cell division and proliferation. Mice (n = 10 per group) were injected with LPS or saline at P9 and BrdU was administered at P11, with the animals sacrificed 2 h after the last BrdU injection (Fig. 1C). We found no effect of LPS on the total number of newborn proliferating cells in the GCL (saline: 6237 ± 541 vs. LPS: 5730 ± 233; p > 0.05, Fig. 4A, B) or in the hilus (saline: 3047 ± 210 vs. LPS: 3402 ± 77; p > 0.05, Fig. 4C, D).
Affiliation: Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.