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Structural analysis of the G-box domain of the microcephaly protein CPAP suggests a role in centriole architecture.

Hatzopoulos GN, Erat MC, Cutts E, Rogala KB, Slater LM, Stansfeld PJ, Vakonakis I - Structure (2013)

Bottom Line: Centrioles are evolutionarily conserved eukaryotic organelles composed of a protein scaffold surrounded by sets of microtubules organized with a 9-fold radial symmetry.The G-box comprises a single elongated β sheet capable of forming supramolecular assemblies.Structural and biophysical studies highlight the conserved nature of the CPAP-STIL complex.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

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Structural analysis of the G-box domain of the microcephaly protein CPAP suggests a role in centriole architecture.

Hatzopoulos GN, Erat MC, Cutts E, Rogala KB, Slater LM, Stansfeld PJ, Vakonakis I - Structure (2013)

© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3824074&req=5

Bottom Line: Centrioles are evolutionarily conserved eukaryotic organelles composed of a protein scaffold surrounded by sets of microtubules organized with a 9-fold radial symmetry.The G-box comprises a single elongated β sheet capable of forming supramolecular assemblies.Structural and biophysical studies highlight the conserved nature of the CPAP-STIL complex.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

Show MeSH
Related in: MedlinePlus