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Sortilins get a new delivery route

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ABSTRACT

Lysosomal sorting receptors transport cargo to secretory granules in Tetrahymena.

No MeSH data available.


Related in: MedlinePlus

FOCAL POINT (Left to right) Aaron Turkewitz, Santosh Kumar, and Joe Briguglio investigate how different classes of cargo proteins are sorted into mucocysts, secretory granules found in the ciliate protozoan Tetrahymena thermophila. The researchers find that SOR2 and SOR4, two members of the sortilin family of lysosomal sorting receptors, target soluble, nonaggregating cargoes to the granules. Grt1p (green), for example, localizes to mucocysts docked at the surface of wild-type Tetrahymena (center) but is missorted and constitutively secreted from SOR4-deficient cells (right). The self-aggregating cargo Grl3p, on the other hand, is still targeted to mucocysts in the absence of SOR4 but isn’t processed into its mature, secretable form due to mislocalization of the protease cathepsin 3.PHOTO COURTESY OF YUSUKE FUKUDA
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fig1: FOCAL POINT (Left to right) Aaron Turkewitz, Santosh Kumar, and Joe Briguglio investigate how different classes of cargo proteins are sorted into mucocysts, secretory granules found in the ciliate protozoan Tetrahymena thermophila. The researchers find that SOR2 and SOR4, two members of the sortilin family of lysosomal sorting receptors, target soluble, nonaggregating cargoes to the granules. Grt1p (green), for example, localizes to mucocysts docked at the surface of wild-type Tetrahymena (center) but is missorted and constitutively secreted from SOR4-deficient cells (right). The self-aggregating cargo Grl3p, on the other hand, is still targeted to mucocysts in the absence of SOR4 but isn’t processed into its mature, secretable form due to mislocalization of the protease cathepsin 3.PHOTO COURTESY OF YUSUKE FUKUDA


Sortilins get a new delivery route
FOCAL POINT (Left to right) Aaron Turkewitz, Santosh Kumar, and Joe Briguglio investigate how different classes of cargo proteins are sorted into mucocysts, secretory granules found in the ciliate protozoan Tetrahymena thermophila. The researchers find that SOR2 and SOR4, two members of the sortilin family of lysosomal sorting receptors, target soluble, nonaggregating cargoes to the granules. Grt1p (green), for example, localizes to mucocysts docked at the surface of wild-type Tetrahymena (center) but is missorted and constitutively secreted from SOR4-deficient cells (right). The self-aggregating cargo Grl3p, on the other hand, is still targeted to mucocysts in the absence of SOR4 but isn’t processed into its mature, secretable form due to mislocalization of the protease cathepsin 3.PHOTO COURTESY OF YUSUKE FUKUDA
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3824010&req=5

fig1: FOCAL POINT (Left to right) Aaron Turkewitz, Santosh Kumar, and Joe Briguglio investigate how different classes of cargo proteins are sorted into mucocysts, secretory granules found in the ciliate protozoan Tetrahymena thermophila. The researchers find that SOR2 and SOR4, two members of the sortilin family of lysosomal sorting receptors, target soluble, nonaggregating cargoes to the granules. Grt1p (green), for example, localizes to mucocysts docked at the surface of wild-type Tetrahymena (center) but is missorted and constitutively secreted from SOR4-deficient cells (right). The self-aggregating cargo Grl3p, on the other hand, is still targeted to mucocysts in the absence of SOR4 but isn’t processed into its mature, secretable form due to mislocalization of the protease cathepsin 3.PHOTO COURTESY OF YUSUKE FUKUDA

View Article: PubMed Central - HTML

ABSTRACT

Lysosomal sorting receptors transport cargo to secretory granules in Tetrahymena.

No MeSH data available.


Related in: MedlinePlus