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Trophic factors and cell therapy to stimulate brain repair after ischaemic stroke.

Gutiérrez-Fernández M, Fuentes B, Rodríguez-Frutos B, Ramos-Cejudo J, Vallejo-Cremades MT, Díez-Tejedor E - J. Cell. Mol. Med. (2012)

Bottom Line: From a therapeutic viewpoint, reparative therapies that encourage cerebral plasticity are needed.However, even when promising results have been obtained in a wide range of experimental animal models and conditions these preliminary results have not yet demonstrated their clinical efficacy.Here, we focus on brain repair modulatory treatments for ischaemic stroke, that use trophic factors, drugs with trophic effects and stem cell therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology and Stroke Centre, La Paz University Hospital, Neuroscience Area of IdiPAZ (Health Research Institute), Autónoma University of Madrid, Madrid, Spain.

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Brain repair therapies through brain plasticity enhancement. Mechanisms underlying cerebral plasticity associated with repair processes. G-CSF: granulocyte colony-stimulating factor; VEGF: vascular endothelial growth factor; BDNF: brain-derived neurotrophic factor; NGF: nerve growth factor; bFGF: basic fibroblast growth factor; IGF-1: insulin growth factor-1; EPO: erythropoietin; MSC: mesenchymal stem cells; UCBC: umbilical cord blood cells; DSC: dental stem cells; ESC: embryonic stem cells; BMSC: bone marrow stem cells; NSC: neural stem cells.
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fig02: Brain repair therapies through brain plasticity enhancement. Mechanisms underlying cerebral plasticity associated with repair processes. G-CSF: granulocyte colony-stimulating factor; VEGF: vascular endothelial growth factor; BDNF: brain-derived neurotrophic factor; NGF: nerve growth factor; bFGF: basic fibroblast growth factor; IGF-1: insulin growth factor-1; EPO: erythropoietin; MSC: mesenchymal stem cells; UCBC: umbilical cord blood cells; DSC: dental stem cells; ESC: embryonic stem cells; BMSC: bone marrow stem cells; NSC: neural stem cells.

Mentions: Trophic factors, stem cell therapy and rehabilitation have all been shown to exert potential therapeutic effects by modulating brain repair- associated mechanisms (Fig. 2). In experimental animals, increased levels of neurogenesis, gliogenesis, oligodendrogenesis and angiogenesis accompanied with better functional recovery have been widely reported after treatment [13, 14]. Such promising pre-clinical results have led to multiple clinical trials in the last years. In this review, we will discuss recent reports from both pre-clinical and clinical studies that raise important new questions and concerns for further advances in the field.


Trophic factors and cell therapy to stimulate brain repair after ischaemic stroke.

Gutiérrez-Fernández M, Fuentes B, Rodríguez-Frutos B, Ramos-Cejudo J, Vallejo-Cremades MT, Díez-Tejedor E - J. Cell. Mol. Med. (2012)

Brain repair therapies through brain plasticity enhancement. Mechanisms underlying cerebral plasticity associated with repair processes. G-CSF: granulocyte colony-stimulating factor; VEGF: vascular endothelial growth factor; BDNF: brain-derived neurotrophic factor; NGF: nerve growth factor; bFGF: basic fibroblast growth factor; IGF-1: insulin growth factor-1; EPO: erythropoietin; MSC: mesenchymal stem cells; UCBC: umbilical cord blood cells; DSC: dental stem cells; ESC: embryonic stem cells; BMSC: bone marrow stem cells; NSC: neural stem cells.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3823421&req=5

fig02: Brain repair therapies through brain plasticity enhancement. Mechanisms underlying cerebral plasticity associated with repair processes. G-CSF: granulocyte colony-stimulating factor; VEGF: vascular endothelial growth factor; BDNF: brain-derived neurotrophic factor; NGF: nerve growth factor; bFGF: basic fibroblast growth factor; IGF-1: insulin growth factor-1; EPO: erythropoietin; MSC: mesenchymal stem cells; UCBC: umbilical cord blood cells; DSC: dental stem cells; ESC: embryonic stem cells; BMSC: bone marrow stem cells; NSC: neural stem cells.
Mentions: Trophic factors, stem cell therapy and rehabilitation have all been shown to exert potential therapeutic effects by modulating brain repair- associated mechanisms (Fig. 2). In experimental animals, increased levels of neurogenesis, gliogenesis, oligodendrogenesis and angiogenesis accompanied with better functional recovery have been widely reported after treatment [13, 14]. Such promising pre-clinical results have led to multiple clinical trials in the last years. In this review, we will discuss recent reports from both pre-clinical and clinical studies that raise important new questions and concerns for further advances in the field.

Bottom Line: From a therapeutic viewpoint, reparative therapies that encourage cerebral plasticity are needed.However, even when promising results have been obtained in a wide range of experimental animal models and conditions these preliminary results have not yet demonstrated their clinical efficacy.Here, we focus on brain repair modulatory treatments for ischaemic stroke, that use trophic factors, drugs with trophic effects and stem cell therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology and Stroke Centre, La Paz University Hospital, Neuroscience Area of IdiPAZ (Health Research Institute), Autónoma University of Madrid, Madrid, Spain.

Show MeSH
Related in: MedlinePlus