Regeneration of infarcted myocardium with resveratrol-modified cardiac stem cells.
Bottom Line: Indeed, the vast majority of host-transfused cells do not survive beyond 24-72 hrs.Rats were anaesthetized, hearts opened and the LAD occluded to induce heart attack.One week later, the cardiac reduced environment was confirmed in resveratrol treated rat hearts by the enhanced expression of nuclear factor-E2-related factor-2 (Nrf2) and redox effector factor-1 (Ref-1).
Affiliation: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.Show MeSH
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Mentions: The first set of experiments was conducted to verify the presence of effective homing and survival of the resveratrol-treated EGFP-labelled cells implanted to the hearts subjected to the LAD occlusion. With this goal we employed fluorescence confocal imaging for analysis of microsections of cardiac tissues harvested at day 3 (not shown) and day 7 following surgery and implantation. High number of the EGFP-expressing cells were observed in the myocardium at day 7 after LAD occlusion (Fig. 1A–D in green).
Affiliation: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.